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Release From Cross-Orientation Suppression Facilitates 3d Shape Perception, Andrea Li, Qasim Zaidi

Publications and Research

Cross-orientation suppression (COS) in striate cortex has been implicated in the efficient encoding of visual stimuli. We show that release from COS facilitates the decoding of 3-D shape. In planar surfaces overlaid with textures, slanting the surface can increase the visibility of the component parallel to the slant. Since this component provides the orientation flows that signify 3-D shape, the enhancement of visibility facilitates 3-D slant perception. Contrast thresholds reveal that this enhancement results from a decrease in COS when 3-D slant creates a frequency mismatch between texture components. We show that coupling compressive nonlinearities in LGN neurons with expansive …

Lmproving Education Through Brain Research, Lisa J. Ihnen

Master of Education Program Theses

Educational practices are improved because of brain research. Cognitive and behavior sciences have provided important concepts for educational practice. Within recent decades, neuroscience has also contributed to the field of brain research, thus enhancing our understanding oflearning. Three main concepts from neuroscience are explored: synaptogenesis, critical periods, and enriched environments. When the entire body of knowledge from all disciplines of brain research is viewed together, then fmdings can be applied to educational practices.

Growth Factor Delivery From Fibrin Matrics Containing Affinity-Based Delivery Systems To Treat Peripheral Nerve Injury, Matthew Wood

All Theses and Dissertations (ETDs)

This thesis work sought to develop a biomaterial to further the understanding of affinity-based delivery and to serve as a potential treatment for peripheral nerve injury. The use of an affinity-based delivery system: ABDS) with growth factors in a nerve guidance conduit: NGC) was hypothesized to promote nerve regeneration and functional recovery following a critical nerve defect. Evaluation of affinity-based delivery using peptides with varying binding affinity for heparin determined that peptide binding affinity for heparin affected the release rate and biological activity of nerve growth factor: NGF) in vitro. The ABDS presented biologically active NGF, which promoted neurite extension …

Dissecting The Molecular Mechanisms Underlying Synpase Development And Neuronal Functions In Caenorhabditis Elegans, Shuo Luo

All Theses and Dissertations (ETDs)

The development and function of the nervous system is under delicate regulation of diverse tissue-derived signals in multi-cellular organisms. In Dr. Nonet's lab, I am using the model organism Caenorhabditis elegans to ask two basic questions: 1) How do different tissues in an organism coordinate to regulate neural functions and behaviors? 2) What controls the development of synapse, the basic unit of the nervous system? These questions divide my dissertation into three parts, with the first two parts related to the first question and the third part to the second question. In the first part of this dissertation, I present …

The Neuropsychology Of Justifications And Excuses: Some Problematic Cases Of Self-Defense, Duress And Provocation, Theodore Y. Blumoff

Theodore Y. Blumoff

In a famous address to the Aristotelian Society, Professor J. L. Austin provided dictum that has become a part of the conventional wisdom in the jurisprudence of our criminal law. His thesis simultaneously acknowledges the evident moral distinction between justifications and excuses, on the one hand, and the tendency, on the other, for the two doctrines to overlap and confound. From the perspectives of moral philosophy and jurisprudence, the distinction is clear. Justifications are socially approved (or, at least, not disapproved); excuses are not approved, but they obtain because the actor’s conduct reflects a substantial (and therefore judicially acknowledged) cognitive …

Brain-Based Education In Music: A New Science Or Science-Fiction?, Diane C. Persellin

Music Faculty Research

We can see increased interest in the brain and brain-based education everywhere. Google turns up over one million hits on “brain-based education.” Nearly every education and music education conference offers sessions that teach ways to utilize new research on the brain. Places like MIT and Stanford increasingly sponsor workshops and courses where teachers pay big bucks to attend “learning and the brain” conferences. They believe this research is substantial enough to use in classrooms.

The number of new books on brain-based education is also startling. Musicophilia: Tales of Music and the Brain by Oliver Sacks and This is Your Brain …

Neuroscientific Evidence In The Law: Fascinating Science, But To Laymen It's Still Phrenology, John M. Mccarthy

John M McCarthy

ABSTRACT

Neuroscientific Evidence in the Law: Fascinating Science, But to Laymen It's Still Phrenology by John M. McCarthy J.D. Yale, 1977

Cognitive neuroscience is one of biology's most exciting specialties, but outside of laboratories, "neuroscience" is not "science" but something else. The article examines what it is. This bears on today's burgeoning "neuro-" applications in the law, including "neuroethics". The article argues that neuroscientific findings should be excluded today from legal contexts, because valid scientific findings do not exist concerning the complex mental performances pertinent to adjudication.

Laymen and neuroscientists embrace a theoretical paradigm that is over two centuries old: …

Right Hemispheric Contributions To Fine Auditory Temporal Discriminations: High-Density Electrical Mapping Of The Duration Mismatch Negativity (Mmn), Pierfilippo De Sanctis, Sophie Molholm, Marina Shpaner, Walter Ritter, John J. Foxe

Publications and Research

That language processing is primarily a function of the left hemisphere has led to the supposition that auditory temporal discrimination is particularly well-tuned in the left hemisphere, since speech discrimination is thought to rely heavily on the registration of temporal transitions. However, physiological data have not consistently supported this view. Rather, functional imaging studies often show equally strong, if not stronger, contributions from the right hemisphere during temporal processing tasks, suggesting a more complex underlying neural substrate. The mismatch negativity (MMN) component of the human auditory evoked-potential provides a sensitive metric of duration processing in human auditory cortex and lateralization …

The Sleeping Brain's Influence On Verbal Memory: Boosting Resistance To Interference, Jeffrey M. Ellenbogen, Justin C. Hulbert, Ying Jiang, Robert Stickgold

Dartmouth Scholarship

Memories evolve. After learning something new, the brain initiates a complex set of post-learning processing that facilitates recall (i.e., consolidation). Evidence points to sleep as one of the determinants of that change. But whenever a behavioral study of episodic memory shows a benefit of sleep, critics assert that sleep only leads to a temporary shelter from the damaging effects of interference that would otherwise accrue during wakefulness. To evaluate the potentially active role of sleep for verbal memory, we compared memory recall after sleep, with and without interference before testing. We demonstrated that recall performance for verbal memory was greater …

Guidelines For Twenty-First Century Instructional Design And Technology Use: Technologies' Influence On The Brain, Jennifer Gabriel

Electronic Theses and Dissertations

The increasingly global environment has spurred the economy in the United States as well as the economies in nearly every other nation. Although the U.S. remains the world leader in the global economy, research shows that the United States is at risk of losing its place as the world leader in science and innovation. Policymakers have recognized the need for research addressing global competitiveness. President Bush signed the America Competes Act, which calls for increased investment in innovation and education to improve U.S. competitiveness and President Barack Obama has named a platform, "Science, Technology and Innovation for a New Generation" …

Behavioral And Neural Representation Of Emotional Facial Expressions Across The Lifespan, Leah Somerville, Fani Negar, Erin Tone

Psychology Faculty Publications

Humans’ experience of emotion and comprehension of affective cues varies substantially across the lifespan. Work in cognitive and affective neuroscience has begun to characterize behavioral and neural responses to emotional cues that systematically change with age. This review examines work to date characterizing the maturation of facial expression comprehension, and dynamic changes in amygdala recruitment from early childhood through late adulthood while viewing facial expressions of emotion. Recent neuroimaging work has tested amygdala and prefrontal engagement in experimental paradigms mimicking real aspects of social interactions, which we highlight briefly, along with considerations for future research.

Neuroscientific Evidence In The Law: Fascinating Science But To Layment It's Still Phrenology (Revised, 2009), John M. Mccarthy

John M McCarthy

ABSTRACT

Neuroscientific Evidence in the Law:

Fascinating Science, but to laymen it's still phrenology

by

John M. McCarthy

Cognitive neuroscience is one of biology's most exciting specialties, but outside of laboratories, "neuroscience" is not "science" but something else. The article examines what it is. This bears on today's burgeoning "neuro-" applications in the law, including "neuroethics". The article argues that neuroscientific findings should be excluded today from legal contexts, because valid scientific findings do not exist concerning the complex mental performances pertinent to adjudication.

Laymen and neuroscientists embrace a theoretical paradigm that is over two centuries old: that a biological …

Legal Storytelling: The Theory And The Practice - Reflective Writing Across The Curriculum, Nancy Levit

Nancy Levit

This article concentrates on the theory of narrative or storytelling and addresses the reasons it is vital to encourage in law schools in non-clinical or primarily doctrinal courses. Section I traces the advent of storytelling in legal theory and practice: while lawyers have long recognized that part of their job is to tell their clients' stories, the legal academy was, for many years, resistant to narrative methodologies. Section II examines the current applications of Writing Across the Curriculum in law schools. Most exploratory writing tasks in law school come in clinical courses, although a few adventurous professors are adding reflective …

Violence On The Brain: A Critique Of Neuroscience In Criminal Law, Amanda C. Pustilnik

Faculty Scholarship

Is there such a thing as a criminally "violent brain"? Does it make sense to speak of "the neurobiology of violence" or the "psychopathology of crime"? Is it possible to answer on a physiological level what makes one person engage in criminal violence and another not, under similar circumstances?

This Article first demonstrates parallels between certain current claims about the neurobiology of criminal violence and past movements that were concerned with the law and neuroscience of violence: phrenology, Lombrosian biological criminology, and lobotomy. It then engages in a substantive review and critique of several current claims about the neurological bases …

Eeg During Pedaling: Brain Activity During A Locomotion-Like Task In Humans, Sanket G. Jain

Master's Theses (2009 -)

This study characterized the brain electrical activity during pedaling, a locomotor-like task, in humans. We postulated that phasic brain activity would be associated with active pedaling, consistent with a cortical role in locomotor tasks. 64 channels of electroencephalogram (EEG) and 10 channels of electromyogram (EMG) data were recorded from 10 neurologically-intact volunteers while they performed active and passive (no effort) pedaling on a custom-designed stationary bicycle. Ensemble average waveforms, two dimensional topographic maps and amplitude of the beta (13-35 Hz) frequency band were analyzed and compared between active and passive trials. The absolute amplitude (peak positive-peak negative) of the EEG …

Tissue Engineered Myelination And The Stretch Reflex Arc Sensory Circuit: Defined Medium Formulation, Interface Design And Microfabrication, John Rumsey

Electronic Theses and Dissertations

The overall focus of this research project was to develop an in vitro tissue-engineered system that accurately reproduced the physiology of the sensory elements of the stretch reflex arc as well as engineer the myelination of neurons in the systems. In order to achieve this goal we hypothesized that myelinating culture systems, intrafusal muscle fibers and the sensory circuit of the stretch reflex arc could be bioengineered using serum-free medium formulations, growth substrate interface design and microfabrication technology. The monosynaptic stretch reflex arc is formed by a direct synapse between motoneurons and sensory neurons and is one of the fundamental …

Stereotype Threat: A Case Of Overclaim Syndrome?, Amy L. Wax

All Faculty Scholarship

The theory of Stereotype Threat (ST) predicts that, when widely accepted stereotypes allege a group’s intellectual inferiority, fears of confirming these stereotypes cause individuals in the group to underperform relative to their true ability and knowledge. There are now hundreds of published studies purporting to document an impact for ST on the performance of women and racial minorities in a range of situations. This article reviews the literature on stereotype threat, focusing especially on studies investigating the influence of ST in the context of gender. It concludes that there is currently no justification for concluding that ST explains women’s underperformance …

Mechanisms Of Feedback In The Visual System, Adam Eggebrecht

All Theses and Dissertations (ETDs)

Feedback is an ubiquitous feature of neural systems though there is little consensus on the roles of mechanisms involved with feedback. We set up an in vivo preparation to study and characterize an accessible and isolated feedback loop within the visual system of the leopard frog, Rana pipiens. We recorded extracellularly within the nucleus isthmi, a nucleus providing direct topographic feedback to the optic tectum, a nucleus that receives the vast majority of retinal output. The optic tectum and nucleus isthmi of the amphibian are homologous structures to the superior colliculus and parabigeminal nucleus in mammals, respectively. We formulated a …

A Quest For Meaning In Spontaneous Brain Activity - From Fmri To Electrophysiology To Complexity Science, Biyu He

All Theses and Dissertations (ETDs)

The brain is not a silent, complex input/output system waiting to be driven by external stimuli; instead, it is a closed, self-referential system operating on its own with sensory information modulating rather than determining its activity. Ongoing spontaneous brain activity costs the majority of the brain's energy budget, maintains the brain's functional architecture, and makes predictions about the environment and the future. I have completed three separate studies on the functional significance and the organization of spontaneous brain activity. The first study showed that strokes disrupt large-scale network coherence in the spontaneous functional magnetic resonance imaging: fMRI) signals, and that …

The Role Of Astrocyte Activation In Infantile Neuronal Ceroid Lipofuscinosis, Shannon Macauley-Rambach

All Theses and Dissertations (ETDs)

Infantile neuronal ceroid lipofuscinoses: INCLs), or Batten Disease, is an inherited neurodegenerative lysosomal storage disorder affecting the central nervous system: CNS) during infancy or childhood. Hallmark pathological changes include accumulation of autofluorescent material, neuronal loss, cortical thinning, and brain atrophy, which ultimately lead to cognitive deficits, motor dysfunction, seizure activity, and blindness. INCL is the result of mutations in the CLN1 gene leading to a deficiency in the lysosomal enzyme, palmitoyl protein thioesterase 1: PPT1). A mouse model of INCL, the PPT1-deficient: PPT1-/-) mouse, was recently created by a targeted disruption in the CLN1 gene. The phenotype of the PPT1-/- …

The Mechanisms And Roles Of Feedback Loops For Visual Processing, Jing Shao

All Theses and Dissertations (ETDs)

Signal flow in the brain is not unidirectional; feedback represents a key element in neural signal processing. To address the question on how do neural feedback loops work in terms of synapses, microcircuitry, and systems dynamics, we developed a chick midbrain slice preparation to study and characterize one important feedback loop within the avian visual system: isthmotectal feedbackloop. The isthmotectal feedback loop consists of the optic tectum: OT) and three nucleus isthmi: Imc, Ipc and SLu. The tectal layer 10 neurons project to ipsilateral Imc, Ipc and SLu in a topographic way. In turn Ipc and SLu send back topographical: …

Medial Temporal Lobe Structure And Function, Meghana Karnik

All Theses and Dissertations (ETDs)

Medial Temporal Lobe Structure and Function by Meghana Sunil Karnik Doctor of Philosophy in Biology and Biomedical Sciences: Neuroscience) Washington University in St. Louis, 2009 Professor John G. Csernansky, Chairperson My main goal was to examine the relationship between brain structure and function, specifically medial temporal lobe structure and episodic memory, in various groups of subjects who had schizophrenia, were at risk for schizophrenia because of genetic and disease influences, or who were healthy, in order to explore the influence of genetic and disease influences on brain structure-function relationships. Most of what is known about the neural structures thought to …

Aggregation & Localization Of A Disease-Associated Prion Protein (Prp) Mutant, Andrea Rhonda Medrano

All Theses and Dissertations (ETDs)

ABSTRACT OF THE DISSERTATION Aggregation & Localization of a Disease-Associated Prion Protein: PrP) Mutant by Andrea Rhonda Zaragoza Medrano Doctor of Philosophy in Biology and Biomedical Sciences: Genetics) Washington University in St. Louis, 2009 Professor David A. Harris, Chairperson Prion protein: PrP) is a GPI-anchored sialoglycoprotein involved in the pathogenesis of infectious and inherited forms of transmissible spongiform encephalopathies: TSEs). A nine-octapeptide insertional mutation in the prion protein: PrP) causes a fatal neurodegenerative disorder in both humans and transgenic mice. To determine the precise cellular localization of this mutant PrP: designated PG14), we have generated transgenic mice expressing PG14-EGFP, a …

Feature Topography And Sound Intensity Level Encoding In Primary Auditory Cortex, Paul Watkins

All Theses and Dissertations (ETDs)

The primary auditory cortex: A1) in mammals is one of the first areas in the neocortex that receives auditory related spiking activity from the thalamus. Because the neocortex is implicated in regulating high-level brain phenomena, such as attention and perception, it is therefore important in regards to these high-level behaviors to understand how sounds are represented and transformed by neuronal circuits in this area. The topographic organization of neuronal responses to auditory features in A1 provides evidence for potential mechanisms and functional roles of this neural circuitry. This dissertation presents results from models of topographic organization supporting the notion that …

The Neuroscientific Study Of The Self: Methodological And Theoretical Challenges, Cynthia J. Najdowski, Samuel E. Winer

Psychology Faculty Scholarship

Neuroscientific research methods, such as brain imaging techniques, have increasingly been applied to social cognitive research efforts and, in particular, to the study of the self. In this essay we discuss the ability of such research to shed light on the emergent, dynamic psychological phenomenon of self. Although neuroscientific tools can be useful for gaining general knowledge about associated underlying structures, a careful consideration of the methodological and theoretical issues discussed herein is necessary to avoid simplifying or reifying the self.

Embryonic And Postnatal Development Of The Neural Circuitry Involved In Motor Control, Valerie Cari Ann Siembab

Browse all Theses and Dissertations

The development of locomotion is believed to result from the maturation of the spinal circuits controlling motor output, however little is known about its mechanisms. To shed some light into this process we studied the development of the synaptic connectivity of two spinal inhibitory interneurons. Adult motoneurons are controlled by inhibitory networks that include recurrent and reciprocal inhibition (Pierrot-Deseilligny & Burke, 2005). Each is modulated by different ventral horn spinal interneurons that display synaptic connectivity adapted to their function: Renshaw cells (RCs) mediate recurrent inhibition, receive excitatory inputs from motor axons and inhibit homonymous and synergistic motoneurons; while Ia inhibitory …

Effect Of Cholinergic Deafferentation Of Prefrontal Cortex On Working Memory For Familiar And Novel Odors, Emily Carter

Master's Theses and Capstones

The role of acetylcholine in the medial prefrontal cortex (mPFC) in working memory was investigated in aged rats. Subjects with cholinergic lesions of the prelimbic portion of the mPFC (pACh-lx) or a sham lesion of the same region were trained on an odor delayed non-match to sample paradigm. The effects of prefrontal cholinergic depletion and aging were assessed in task variations that manipulated mnemonic demand and stimulus novelty.

pACh-lx animals were impaired relative to sham-lx animals at memory for familiar stimuli over delays. This global impairment was not dependent on the length of the delay, suggesting that aged pACh-lx animals …

Remarks: Neuroscience, Gender, And The Law, Stacey A. Tovino

Scholarly Works

These remarks, delivered at the Neuroscience, Law, and Government Symposium held at the University of Akron School of Law in 2009, explore how stakeholders are using advances in the neuroscience of three gender-specific and gender-prevalent conditions (the postpartum mood disorders, premenstrual dysphoric disorder, and eating disorders) to secure health care benefits under group health plans and individual health insurance policies and to push for the inclusion of these conditions in mental health parity legislation.

Brain Imaging For Legal Thinkers: A Guide For The Perplexed, Owen D. Jones, Joshua W. Buckholtz, Jeffrey D. Schall, Rene Marois

Vanderbilt Law School Faculty Publications

It has become increasingly common for brain images to be proffered as evidence in criminal and civil litigation. This Article - the collaborative product of scholars in law and neuroscience - provides three things.

First, it provides the first introduction, specifically for legal thinkers, to brain imaging. It describes in accessible ways the new techniques and methods that the legal system increasingly encounters.

Second, it provides a tutorial on how to read and understand a brain-imaging study. It does this by providing an annotated walk-through of the recently-published work (by three of the authors - Buckholtz, Jones, and Marois) that …

Neuroscience, Law & Government: Foreword To The Symposium, Jane Moriarty

Jane Campbell Moriarty

The legal and legislative systems have begun to rely on neuroscience in various types of decision-making. Without question, the relationship between the disciplines will become more enmeshed as more data is generated by neuroscientists. Are we ready for this potential sea change that will be both rich and strange?