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Septal Infusions Of The H-Channel Blocker Zd7288 Impair Spontaneous Alternation But Not Inhibitory Avoidance, Ramata Sissoko Cisse
Septal Infusions Of The H-Channel Blocker Zd7288 Impair Spontaneous Alternation But Not Inhibitory Avoidance, Ramata Sissoko Cisse
Biology Theses
It is well established that the septo-hippocampal system is involved in memory. The medial septum is connected to the hippocampus via the fimbria fornix, which consists mostly of acetylcholine and ã-aminobutyric acid (GABA) projection neurons. The contributions of the cholinergic projection to memory have been studied extensively; whereas, the role of the GABAergic projection is not well characterized. The present experiment tested whether septal infusions of the selective H-channel blocker ZD7288 would impair spontaneous alternation (SA) and continuous multiple inhibitory avoidance (CMIA). Fifteen minutes prior to assessing SA or CMIA, different groups of male Sprague-Dawley rats were given septal infusions …
Effects Of Lesions Of The Bed Nucleus Of The Stria Terminalis, Laterual Hypothalamus, Or Insular Cortex On Conditioned Taste Aversion And Conditioned Odor Aversion, Christopher T. Roman, Nino Nebieridze, Aristides Sastre, Steve Reilly
Effects Of Lesions Of The Bed Nucleus Of The Stria Terminalis, Laterual Hypothalamus, Or Insular Cortex On Conditioned Taste Aversion And Conditioned Odor Aversion, Christopher T. Roman, Nino Nebieridze, Aristides Sastre, Steve Reilly
Scholarship and Professional Work – COPHS
The effects of permanent forebrain lesions on conditioned taste aversions (CTAs) and conditioned odor aversions (COAs) were examined in 3 experiments. In Experiment 1, lesions of the bed nucleus of the stria terminalis had no influence on CTA or COA acquisition. Although lesions of the lateral hypothalamus induced severe hypodipsia in Experiment 2, they did not prevent the acquisition of CTAs or COAs. Finally, in Experiment 3, lesions of the insular cortex retarded CTA acquisition but had no influence on COA acquisition. The implications of these findings are discussed with regard to the forebrain influence on parabrachial nucleus function during …