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Construction Of A Col11a1 Transgene Vector, Cameron Mckell Beck
Construction Of A Col11a1 Transgene Vector, Cameron Mckell Beck
Theses and Dissertations
Background: Cartilage disorders affect millions of people in the United States alone, with effects ranging from poor skeletal development and joint pain to shortened lifespan and perinatal lethality. Many of these disorders have their root in defects of collagen, type XI collagen being among the most important. A mouse model of such a type XI collagen defect is the chondrodysplasia (cho) mutant. Mice homozygous for this null mutation in the Col11a1 gene do not express the α1 chain of type XI collagen. This results in a functional knockout of type XI collagen, leading to insufficient skeletal development and perinatal lethality. …
Modulation Of Fast And Slow Inactivation In Two Cardiac Nav Channel Isoforms By Sdz 211-939, Tyce Jeffrey Kearl
Modulation Of Fast And Slow Inactivation In Two Cardiac Nav Channel Isoforms By Sdz 211-939, Tyce Jeffrey Kearl
Undergraduate Honors Capstone Projects
Here we report a hitherto unknown effect of a synthetic inactivation inhibitor on inactivation in cardiac sodium channels (Nav1.5) from two different species: human and bovine. SDZ 211-93 9 stabilized the slow inactivated-state in both channels as seen by an increased steady-state probability of slow inactivation. SDZ also destabilized the fast-inactivated state and increased the amplitude of persistent currents. SDZ modulated conductance parameters, open-state fast inactivation time constants, and activation kinetics of hNav1.5, but not bNav1.5. These findings will aid future studies designed to elucidate the binding site and molecular mechanisms of inactivation inhibitors …
Paleoepidemiology Of Bacterial Infections Among Prehistoric Human Populations In Northern Chile: An Ancient Dna Approach, Luz-Andrea Pfister
Paleoepidemiology Of Bacterial Infections Among Prehistoric Human Populations In Northern Chile: An Ancient Dna Approach, Luz-Andrea Pfister
UNLV Retrospective Theses & Dissertations
Bacterial pathogens not primarily affecting the skeleton but causing sepsis and death, have not been systematically studied in prehistoric human populations, although increasing evidence support our species long co-evolution with many of them. With molecular methods we can identify bacteria at the species level and distinguish pathogenic from environmental and soil bacteria. Bone marrow of ancient people may provide valuable information about ancient pathogens causing sepsis and death. To test the hypothesis that PCR amplification using universal bacterial primers will identify prehistoric bacterial pathogens in bone marrow, 30 samples were aseptically obtained from partially mummified remains of three archaeological sites …
Effect Of Low Level Laser Therapy On Migration Of Human Skin Cells Across A Standardized Wound, Kathleen Orzechowski
Effect Of Low Level Laser Therapy On Migration Of Human Skin Cells Across A Standardized Wound, Kathleen Orzechowski
UNLV Retrospective Theses & Dissertations
The purpose of this study was to examine the effects that different dosages of low level laser therapy have on human skin cell migration. Normal newborn foreskin fibroblasts were seeded into a four well chamber microscope slide. Cellular monolayers were inflicted with three standardized wounds per well. Following the wounding of cells, each well received low level laser therapy once from a 635 nm laser at one of four treatment dosages (0.0 J/cm 2, 1.0 J/cm2, 1.5 J/cm2, 2.0 J/cm 2) with a power output of 11.5 mW. Digital images were recorded immediately following wounding, and every hour thereafter for …
Application Of Computational Fluid Dynamics For High Energy Efficiency Design With Human Comfort Of Cad-Vav And Ufad Systems, Bhanu Rekha Bandhakavi
Application Of Computational Fluid Dynamics For High Energy Efficiency Design With Human Comfort Of Cad-Vav And Ufad Systems, Bhanu Rekha Bandhakavi
UNLV Retrospective Theses & Dissertations
This thesis deals with the numerical simulation of the ceiling air distribution (CAD) system and the Under Floor Air Distribution (UFAD) system based on the dimensions of BTLab at UNLV. Ceiling Air Distribution (CAD) with variable air volume (VAV) and Under Floor Air Distribution (UFAD) systems have been widely used in different countries. CAD-VAV and UFAD systems designs have been influenced by increasing emphasis on indoor air quality (IAQ), energy conservation, environmental effects, safety, and economics. So, 3-D Computational Fluid Dynamics (CFD) analysis technique was applied to design high energy efficiency and human comfort CAD-VAV and UFAD systems. The goal …
Utility Of Health Belief Model Constructs In Predicting Dietary Behaviors Among Female University Students: A Pilot Investigation, Vanessa Emily Anderson
Utility Of Health Belief Model Constructs In Predicting Dietary Behaviors Among Female University Students: A Pilot Investigation, Vanessa Emily Anderson
Electronic Theses and Dissertations
This study examined the relationship between Health Belief Model constructs as they related to dietary behaviors in a sample of university women 18-to-25 years of age (n=182). A cross-sectional, non-experimental design was utilized. Independent sample t-tests compared the mean of body mass indices (BMI) to dietary risk and race. Odds ratios amassed relationships between race and healthy food choices. Nearly one-third (32.4%) of participants were either overweight or obese. Black females had significantly higher BMI than white females; however, dietary risk from less-than-adequate fruit and vegetable consumption and consumption of high-fat foods were not related to race. Focus group participants …