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The Effects Of Hemoglobin-Based Oxygen Carriers On Mean Arterial Pressure, Arteriolar Diameter, And Nitric Oxide In The Microcirculation, Veronique C. Hionis
The Effects Of Hemoglobin-Based Oxygen Carriers On Mean Arterial Pressure, Arteriolar Diameter, And Nitric Oxide In The Microcirculation, Veronique C. Hionis
Theses and Dissertations
In the US today, blood transfusion is safer than ever. Nevertheless, the century-old quest for a suitable blood substitute persists. The elimination of unwanted side effects, especially transfusion-transmitted diseases, the problems and high cost factor involved in collecting and storing human blood, the pending worldwide shortages, and the need for compatibility testing are the driving forces contributing towards the development of blood substitutes. The leading research is focusing on hemoglobin-based oxygen carriers (HBOCs), which are limited in clinical application due to the pressor effect they induce. In this study, the mechanisms through which HBOCs affect mean arterial pressure (MAP), arteriolar …