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Passive Stretching Decreases Glial Cell Line-Derived Neurotrophic Factor Expression In Skeletal Muscle And Is Dependent Upon Acetylcholine Receptor Activation, Nathan G. Peplinski, John M. Spitsbergen
Passive Stretching Decreases Glial Cell Line-Derived Neurotrophic Factor Expression In Skeletal Muscle And Is Dependent Upon Acetylcholine Receptor Activation, Nathan G. Peplinski, John M. Spitsbergen
Biological Sciences Faculty and Graduate Student Research
Motor neurons receive trophic support from the tissues they innervate. One molecule that is important for peripheral motor neurons is glial cell-line derived neurotrophic factor (GDNF). We have previously reported that GDNF is regulated in an activity-dependent manner in skeletal muscle. For this study we examined the short-term effects of passive stretching on the expression of GDNF in skeletal muscle. Extensor digitorum longus (EDL) muscles were removed from 4 week old Sprague Dawley rats and placed in oxygenated tissue baths containing Ringer’s solution. Tissues were passively stretched for 4 hours while their contralateral counterparts remained in baths at resting tension. …