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Endothelial Cell Mediators Of Angiogenesis In Bartonella Henselae Infection, Amy M. Mccord
Endothelial Cell Mediators Of Angiogenesis In Bartonella Henselae Infection, Amy M. Mccord
USF Tampa Graduate Theses and Dissertations
Bacillary angiomatosis (BA), one of the clinical manifestations resulting from infection with the facultative intracellular bacterium Bartonella henselae, is characterized by angiogenic lesions. Endothelial cells have been identified as host cells for this pathogen and are presumed important for pathogenesis as lesions contain bacteria in direct contact with the endothelium. Lesions also contain infiltrating macrophages, which contribute to the angiogenic process during B. henselae infection by secreting vascular endothelial growth factor (VEGF). While virulence factors have been characterized, and the role for macrophages in B. henselae infection has been established, endothelial cell mediators of angiogenesis have not been well defined. …
Design And Synthesis Of Core Structural Intermediates For Novel Hiv-1 Protease Inhibitors & Synthesis, Biological Activity And Molecular Modeling Of Novel 20s Proteasome Inhibitors, Kiran Kumar Venkata Raja Avancha
Design And Synthesis Of Core Structural Intermediates For Novel Hiv-1 Protease Inhibitors & Synthesis, Biological Activity And Molecular Modeling Of Novel 20s Proteasome Inhibitors, Kiran Kumar Venkata Raja Avancha
USF Tampa Graduate Theses and Dissertations
HIV-1 protease binds to its peptide/protein substrates in extended conformations. Therefore protease inhibitors that are constrained to form extended conformations are likely to produce very active protease inhibitors. This is because they are pre-organized to form favorable interactions with the enzyme environment immediately surrounding the active site. With this hypothesis in mind, we designed a family of structurally related molecules, which contain dipeptide analogs constrained to adopt the extended conformation. Core structural intermediates that are required for the total synthesis of the novel class of HIV-1 protease inhibitors are outlined in Chapter One. Chapter Two discusses the enantioselective synthesis of …
Investigation Of The Effects Of Increased Levels Of O-Glcnac Protein Modification On Protein Kinase C And Akt, Jason Aaron Matthews
Investigation Of The Effects Of Increased Levels Of O-Glcnac Protein Modification On Protein Kinase C And Akt, Jason Aaron Matthews
USF Tampa Graduate Theses and Dissertations
O-linked N-acetylglucosamine (O-GlcNAc) is an abundant and ubiquitous post-translational modification that has been shown to play a role in regulating a variety of intracellular processes. The pathway responsible for generating the O-GlcNAc modification, the hexosamine biosynthetic pathway (HBP), has also been shown to affect the activity and translocation of certain protein kinase C (PKC) isoforms. To investigate if the effects of HBP flux on PKC translocation observed by others is related to the O-GlcNAc modification, O-GlcNAc levels in human astroglial cells were elevated using four separate O-GlcNAc modulating agents followed by analysis of cytosol and membrane concentrations of PKC-epsilon, -alpha, …