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2007 Tschochner Superiority Of Infectivity-Based Over Particle-Based Methods For Quantitation Of Drug Resistant Hiv-1 As Inocula For Cell Cultures.Pdf, M Tschochner

Monika Tschochner

No abstract provided.

The Plant Structure Ontology, A Unified Vocabulary Of Anatomy And Morphology Of A Flowering Plant, Katica Ilic, Elizabeth A. Kellogg, Pankaj Jaiswal, Felipe Zapata, Peter F. Stevens, Leszek P. Vincent, Shulamit Avraham, Leonore Reiser, Anuradha Pujar, Martin M. Sachs, Noah T. Whitman, Susan R. Mccouch, Mary L. Schaeffer, Doreen H. Ware, Lincoln D. Stein, Seung Y. Rhee

Peter Stevens

Modeling The Incubation Period Of Anthrax, Ron Brookmeyer, Elizabeth Johnson, Sarah Barry

Ron Brookmeyer

Models of the incubation period of anthrax are important to public health planners because they can be used to predict the delay before outbreaks are detected, the size of an outbreak and the duration of time that persons should remain on antibiotics to prevent disease. The difficulty is that there is little direct data about the incubation period in humans. The objective of this paper is to develop and apply models for the incubation period of anthrax. Mechanistic models that account for the biology of spore clearance and germination are developed based on a competing risks formulation. The models predict …

Assessing The Effectiveness Of Antiretroviral Adherence Interventions: Using Marginal Structural Models To Replicate The Findings Of Randomized Controlled Trials., Maya L. Petersen, Yue Wang, Mark J. Van Der Laan, David R. Bangsberg

Maya Petersen

Randomized controlled trials of interventions to improve adherence to antiretroviral medications are not always feasible. Marginal Structural Models (MSM) are a statistical methodology that aims to replicate the findings of randomized controlled trials using observational data. Under the assumption of no unmeasured confounders, three MSM estimators are available to estimate the causal effect of an intervention. Two of these estimators, G-computation and Inverse Probability of Treatment Weighted, can be implemented using standard software. G-computation relies on fitting a multivariable regression of adherence on the intervention and confounders. Thus, it is related to the standard multivariable regression approach to estimating causal …

Modeling An Outbreak Of Anthrax, Ron Brookmeyer

Ron Brookmeyer

Introduction

On October 2, 2001 a sixty-three-year-old Florida man who worked as a photo editor at a media publishing company was admitted to an emergency department complaining of nausea, vomiting, and fever. His symptoms began four days earlier on a recreational trip to North Carolina. The man died shortly thereafter. An astute clinician quickly made the surprising diagnosis of inhalational anthrax, which is a serious and deadly disease. The diagnosis was surprising because inhalational anthrax is extremely rare; only 18 cases were reported in the United States between 1900 and 1978. Public health officials at first believed that the Florida …

Airborne Measurements Of Carbonaceous Aerosol Soluble In Water Over Northeastern United States: Method Development And An Investigation Into Water-Soluble Organic Carbon Sources, A. P. Sullivan, Richard E. Peltier, C. A. Brock, J. A. De Gouw, J. S. Holloway, C. Warneke, A. G. Wollny, R. J. Weber

Richard E. Peltier

A particle-into-liquid sampler (PILS) was coupled to a total organic carbon (TOC) analyzer for 3 s integrated measurements of water-soluble organic carbon (WSOC) in PM1 ambient particles. The components of the instrument are described in detail. The PILS-TOC was deployed on the NOAA WP-3D aircraft during the NEAQS/ITCT 2004 program to investigate WSOC sources over the northeastern United States and Canada. Two main sources were identified: biomass burning emissions from fires in Alaska and northwestern Canada and emissions emanating from urban centers. Biomass burning WSOC was correlated with carbon monoxide (CO) and acetonitrile (r2 > 0.88). These plumes were intercepted in …

Concentrations And Sources Of Organic Carbon Aerosols In The Free Troposphere Over North America, Colette L. Heald, Daniel J. Jacob, Solène Turquety, Rynda C. Hudman, Rodney J. Weber, Amy P. Sullivan, Richard E. Peltier, Eliot L. Atlas, Joost A. De Gouw, Carsten Warneke, John S. Holloway, J. Andrew Neuman, John H. Seinfeld, Frank M. Flocke

Richard E. Peltier

Aircraft measurements of water-soluble organic carbon (WSOC) aerosol over NE North America during summer 2004 (ITCT-2K4) are simulated with a global chemical transport model (GEOS-Chem) to test our understanding of the sources of organic carbon (OC) aerosol in the free troposphere (FT). Elevated concentrations were observed in plumes from boreal fires in Alaska and Canada. WSOC aerosol concentrations outside of these plumes average 0.9 ± 0.9 mg C m 3 in the FT (2–6 km). The corresponding model value is 0.7 ± 0.6 mg C m 3, including 42% from biomass burning, 36% from biogenic secondary organic aerosol (SOA), and …

Internet Chat Rooms: Connecting With A New Generation Of Young Men Of Color At Risk For Hiv Infection Who Have Sex With Other Men., Sheldon Fields

Sheldon D. Fields

The purpose of this study was to explore the use of gay-related Internet chat rooms by young men who have sex with other men of color (YMSMC) in a specific catchment area. Participants were 104 YMSMC age 18 to 24 (M = 21.56) who were encountered in two gay-related Internet chat rooms during April 2005. Participants were mainly African American (53.7%, n = 56), HIV-negative (57.6%, n = 60), and online looking for some type of sexual encounter (80.7%, n = 84). The results of this study support the need to develop specific culturally appropriate HIV prevention Internet outreach protocols …

Age-Related Dystrophin–Glycoprotein Complex Structure And Function In The Rat Extensor Digitorum Longus And Soleus Muscle, Kevin M. Rice, Deborah L. Preston, David Neff, Michael L. Norton, Eric R. Blough

Eric Blough

Age-Related Dystrophin–Glycoprotein Complex Structure And Function In The Rat Extensor Digitorum Longus And Soleus Muscle, Kevin M. Rice, Deborah L. Preston, David Neff, Michael L. Norton, Eric R. Blough

Kevin M Rice

Age-Related Dystrophin–Glycoprotein Complex Structure And Function In The Rat Extensor Digitorum Longus And Soleus Muscle, Kevin M. Rice, Deborah L. Preston, David Neff, Michael L. Norton, Eric R. Blough

Deborah L Preston

Exposure To Environmentally Relevant Doses Of The Xenoestrogen Bisphenol-A Alters Development Of The Fetal Mouse Mammary Gland, Laura Vandenberg, Maricel V. Maffini, Perinaaz R. Wadia, Carlos Sonnenschein, Beverly S. Rubin, Ana M. Soto

Laura Vandenberg

Humans are routinely exposed to bisphenol-A (BPA), an estrogenic compound that leaches from dental materials, food and beverage containers, and other plastic consumer products. Effects of perinatal BPA exposure on the mouse mammary gland have been observed in puberty and adulthood, long after the period of exposure has ended. The aim of this study was to examine fetal mammary gland development at embryonic day (E)18 and assess changes in the tissue organization and histoarchitecture after exposure to an environmentally relevant dose of BPA. In unexposed fetuses, the relative position of the fetus with respect to its female and male siblings …

Exhaled-Breath Condensate Ph Can Be Safely And Continuously Monitored In Mechanically Ventilated Patients, Brian Walsh

Brian Walsh

No abstract provided.

Psychosocial And Spiritual Factors Associated With Smoking And Substance Use During Pregnancy In African-American And Caucasian Low-Income Women, Darlene Elizabeth Jesse

D. Elizabeth Jesse

No abstract provided.

Information-Seeking Behavior Of Faculty In One School Of Public Health, Lisa C. Wallis

Lisa C. Wallis, MSPH, MS

Single-Particle Mass Spectrometry Of Tropospheric Aerosol Particles, D. M. Murphy, D. J. Cziczo, K. D. Froyd, P. K. Hudson, B. M. Matthew, A. M. Middlebrook, Richard E. Peltier, A. Sullivan, D. S. Thomson, R. J. Weber

Richard E. Peltier

The Particle Analysis by Laser Mass Spectrometry (PALMS) instrument has measured the composition of single particles during a number of airborne and ground-based campaigns. In the regions studied, 30% to over 80% of the aerosol mass in the free troposphere was carbonaceous material. Most of this carbonaceous material was probably organic. Although there were variations in their amounts, over 90% of accumulation mode particles away from local sources were internal mixtures of sulfates and carbonaceous material. Within this internal mixing, there was variation in the pattern of carbonaceous peaks in the spectra, especially in peaks related to organic acids. Particles …

A Comprehensive Analysis Of The Androgen Receptor Gene And Risk Of Breast Cancer: Results From The National Cancer Institute Breast And Prostate Cancer Cohort Consortium (Bpc3), David G. Cox, Hélène Blanché, Celeste L. Pearce, Eugenia E. Calle, Graham A. Colditz, Malcolm C. Pike, Demetrius Albanes, Naomi E. Allen, Pilar Amiano, Goran Berglund, Heiner Boeing, Julie Buring, Noel Burtt, Federico Canzian, Stephen Chanock, Françoise Clavel-Chapelon, Heather S. Feigelson, Matthew Freedman, Christopher A. Haiman, Susan E. Hankinson, Brian E. Henderson, Robert Hoover, David J. Hunter, Rudolf Kaaks, Laurence Kolonel, Peter Kraft, Loic Lemarchand, Eiliv Lund, Domenico Palli, Petra H.M. Peeters, Elio Riboli, Daniel O. Stram, Michael Thun, Anne Tjonneland, Dimitrios Trichopoulos, Meredith Yeager

Graham Andrew Colditz

Introduction: Androgens have been hypothesised to influence risk of breast cancer through several possible mechanisms, including their conversion to estradiol or their binding to the oestrogen receptor and/or androgen receptor (AR) in the breast. Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). Methods: The underlying genetic variation was determined by first sequencing the coding regions of the AR gene in a panel of 95 advanced breast cancer cases. Second, …

A Comprehensive Analysis Of The Androgen Receptor Gene And Risk Of Breast Cancer: Results From The National Cancer Institute Breast And Prostate Cancer Cohort Consortium (Bpc3), David G. Cox, Hélène Blanché, Celeste L. Pearce, Eugenia E. Calle, Graham A. Colditz, Malcolm C. Pike, Demetrius Albanes, Naomi E. Allen, Pilar Amiano, Goran Berglund, Heiner Boeing, Julie Buring, Noel Burtt, Federico Canzian, Stephen Chanock, Françoise Clavel-Chapelon, Heather S. Feigelson, Matthew Freedman, Christopher A. Haiman, Susan E. Hankinson, Brian E. Henderson, Robert Hoover, David J. Hunter, Rudolf Kaaks, Laurence Kolonel, Peter Kraft, Loic Lemarchand, Eiliv Lund, Domenico Palli, Petra H.M. Peeters, Elio Riboli, Daniel O. Stram, Michael Thun, Anne Tjonneland, Dimitrios Trichopoulos, Meredith Yeager

Susan E. Hankinson

Introduction: Androgens have been hypothesised to influence risk of breast cancer through several possible mechanisms, including their conversion to estradiol or their binding to the oestrogen receptor and/or androgen receptor (AR) in the breast. Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). Methods: The underlying genetic variation was determined by first sequencing the coding regions of the AR gene in a panel of 95 advanced breast cancer cases. Second, …

Exploiting The Enhanced Permeability And Retention Effect For Tumor Targeting., Arun Iyer

Arun Iyer

Of the tumor targeting strategies, the enhanced permeability and retention (EPR) effect of macromolecules is a key mechanism for solid tumor targeting, and considered a gold standard for novel drug design. In this review, we discuss various endogenous factors that can positively impact the EPR effect in tumor tissues. Further, we discuss ways to augment the EPR effect by use of exogenous agents, as well as practical methods available in the clinical setting. Some innovative examples developed by researchers to combat cancer by the EPR mechanism are also discussed.

Neuroprotective And Disease-Modifying Effects Of The Ketogenic Diet, Maciej Gasior, Michael A. Rogawski, Adam L. Hartman

Michael A. Rogawski

The ketogenic diet has been in clinical use for over 80 years, primarily for the symptomatic treatment of epilepsy. A recent clinical study has raised the possibility that exposure to the ketogenic diet may confer long-lasting therapeutic benefits for patients with epilepsy. Moreover, there is evidence from uncontrolled clinical trials and studies in animal models that the ketogenic diet can provide symptomatic and disease-modifying activity in a broad range of neurodegenerative disorders including Alzheimer’s disease and Parkinson’s disease, and may also be protective in traumatic brain injury and stroke. These observations are supported by studies in animal models and isolated …

Beliefs About Essences And The Reality Of Mental Disorders, Woo-Kyoung Ahn, Elizabeth H. Flanagan, Jessecae K. Marsh, Charles A. Sanislow

Charles A. Sanislow, Ph.D.

Do people believe mental disorders are real and possess underlying essences? The current study found that both novices and practicing clinicians held weaker essentialist beliefs about mental disorders than about medical disorders. They were also unwilling to endorse the idea that mental disorders are real and natural. Furthermore, compared with novices, mental health clinicians were less likely to endorse the view that there is a shared cause underlying a mental disorder and that one needs to remove the cause to get rid of the mental disorder. Clinicians were polarized on their views about whether mental disorders are categorical or dimensional. …

Relations Of Caregiving Stress And Health Depend On The Health Indicators Used And Gender, Hsin-Hua C. Lin

H. Cynthia Lin

No abstract provided.

Supporting Young People To Seek Professional Help For Mental Health Problems: Cover Feature., Coralie J. Wilson

Coralie J Wilson

No abstract provided.

Mental Rubbernecking To Negative Information Depends On Task Context, Marcia K. Johnson, Karen J. Mitchell, Carol L. Raye, Joseph T. Mcguire, Charles A. Sanislow

Charles A. Sanislow, Ph.D.

We previously demonstrated mental rubbernecking during the simple cognitive act of refreshing a just activated representation. Participants saw two neutral and one negative word presented simultaneously and, 425 msec later, were cued to mentally refresh (i.e., think of) one of the no-longer-present words. They were slower to refresh a neutral word than the negative word (Johnson et al., 2005, Experiment 6A). The present experiments extended that work by showing mental rubbernecking when negative items were sometimes the target of refreshing, but not when negative items were present but never the target of refreshing, indicating that expectations influence mental rubbernecking. How …

Amsn Board Votes To Support The Coalition For Patient's Rights, Noel M. Kerr Phd, Rn, Cmsrn

Noël M Kerr PhD, RN, CMSRN

No abstract provided.

Descriptive And Longitudinal Observations On The Relationship Of Borderline Personality Disorder And Bipolar Disorder, John G. Gunderson, Igor Weinberg, Maria T. Daversa, Karsten D. Kueppenbender, Mary C. Zanarini, M. Tracie Shea, Andrew E. Skodol, Charles A. Sanislow, Shirley Yen, Leslie C. Morey, Carlos M. Grilo, Thomas H. Mcglashan, Robert L. Stout, Ingrid R. Dyck

Charles A. Sanislow, Ph.D.

OBJECTIVE: The purpose of this study was to test whether borderline personality disorder is a variant of bipolar disorder by examining the rates of co-occurrence in both disorders, the effects of co-occurrence on a longitudinal course, and whether the presence of either disorder confers the risk for new onsets of the other.

METHOD: A prospective repeated-measures design with reliable independent diagnostic measures and 4 years of follow-up was used to assess 196 patients with borderline personality disorder and 433 patients with other personality disorders.

RESULTS: Patients with borderline personality disorder had a significantly higher co-occurrence of bipolar disorder (19.4%) than …

Digit Force Control In Older Adults: Benefits Of Resistance-Training?, Justin W.L. Keogh

Justin Keogh

This paper seeks to review the effect on digit force control of: 1) the ageing process; and 2) the resistance-training in older adults. Significant age-related decreases in finger-pinch force control were observed in many but not all studies. Those that didn't report age-related differences involved bi-digit finger-pinch tasks requiring the production of constant forces only. This suggests that the age-related decline in force control becomes more pronounced the more challenging the force production task. While three studies reported that resistance-training improved older adults' digit force control capabilities, it is unclear if these improvements would occur in tasks that: 1) require …

Injury Prevalence Among Children And Adolescents With Mental Retardation, Elspeth M. Slayter, Deborah W. Garnick, Joanna M. Kubisiak, Christine E. Bishop, Daniel M. Gilden, Rosemarie B. Hakim

Elspeth Slayter

Clinical Evaluation Of Keratin-Gelatin Composite Film For Wound Healing In Cats, Arul Jothi N., Thilagar S, Khaled M.A Hussin, Gayathri Thevi S, Sastry T.P

Khaled M.A Hussin

Relationship Between Mechanisms And Activities At The Time Of Pedestrian Injury And Activity Limitation Among School Adolescents In Kathmandu, Nepal, Kalpana Poudel-Tandukar, Shinji Nakahara, Masao Ichikawa, Krishna Poudel, Susumu Wakai

Kalpana Poudel-Tandukar