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Gallic Acid: Inhibiting Angiogenesis In Adipose Tissue, Andrew Thaxton Roberts

LSU Master's Theses

Angiogenesis is the process of developing and elongating blood vessels. In obesity, angiogenesis controls the development of the adipose tissue, allowing it to expand as energy stores increase. When angiogenesis is blocked in rodent models, adipose tissue not only stops expanding, but regresses, proving a possible mechanism for weight loss. Nt, a Chinese herbal decoction, and gallic acid, an active antiangiogenic ingredient in Nt, were tested in clinical trials in combination for possible use as a supplement for weight loss. The Nt-gallic acid combination did not cause weight loss or a decrease in food intake in humans, principally due to …