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Cytokine Response At High Altitude: Effects Of Exercise And Antioxidants At 4300 M, Todd A. Hagobian, Kevin A. Jacobs, Andrew W. Subudhi, Jill A. Fattor, Paul B. Rock, Stephen R. Muza, Charles S. Fulco, Barry Braun, Ann Grediagin, Robert S. Mazzeo, Allen Cymerman, Anne L. Friedlander
Cytokine Response At High Altitude: Effects Of Exercise And Antioxidants At 4300 M, Todd A. Hagobian, Kevin A. Jacobs, Andrew W. Subudhi, Jill A. Fattor, Paul B. Rock, Stephen R. Muza, Charles S. Fulco, Barry Braun, Ann Grediagin, Robert S. Mazzeo, Allen Cymerman, Anne L. Friedlander
Kinesiology and Public Health
Purpose: This study tested the hypothesis that antioxidant supplementation would attenuate plasma cytokine (IL-6, tumor necrosis factor (TNF)-α), and C-reactive protein (CRP) concentrations at rest and in response to exercise at 4300-m elevation.
Methods: A total of 17 recreationally trained men were matched and assigned to an antioxidant (N = 9) or placebo (N = 8) group in a double-blinded fashion. At sea level (SL), energy expenditure was controlled and subjects were weight stable. Then, 3 wk before and throughout high altitude (HA), an antioxidant supplement (10,000 IU β-carotene, 200 IU α-tocopherol acetate, 250 mg ascorbic …