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Multiplatform Genome-Wide Identification And Modeling Of Functional Human Estrogen Receptor Binding Sites, Chin-Yo Lin, Vinsensius B. Vega, Koon Siew Lai, Li Say Kong, Min Xie, Xiaodi Su, Huey Fang The, Jane S. Thomsen, Ai Li Yeo, Wing Kin Sung, Guillaume Bourque, Edison T. Liu
Multiplatform Genome-Wide Identification And Modeling Of Functional Human Estrogen Receptor Binding Sites, Chin-Yo Lin, Vinsensius B. Vega, Koon Siew Lai, Li Say Kong, Min Xie, Xiaodi Su, Huey Fang The, Jane S. Thomsen, Ai Li Yeo, Wing Kin Sung, Guillaume Bourque, Edison T. Liu
Faculty Publications
Transcription factor binding sites (TFBS) impart specificity to cellular transcriptional responses and have largely been defined by consensus motifs derived from a handful of validated sites. The low specificity of the computational predictions of TFBSs has been attributed to ubiquity of the motifs and the relaxed sequence requirements for binding. We posited that the inadequacy is due to limited input of empirically verified sites, and demonstrated a multiplatform approach to constructing a robust model. Results: Using the TFBS for the estrogen receptor (ER)alpha (estrogen response element [ERE]) as a model system, we extracted EREs from multiple molecular and genomic platforms …
Preliminary Modeling, Control, And Trajectory Design For Miniature Autonomous Tailsitters, Nathan B. Knoebel, Stephen R. Osborne, Deryl Snyder, Timothy W. Mclain, Randal W. Beard, Andrew Mark Eldredge
Preliminary Modeling, Control, And Trajectory Design For Miniature Autonomous Tailsitters, Nathan B. Knoebel, Stephen R. Osborne, Deryl Snyder, Timothy W. Mclain, Randal W. Beard, Andrew Mark Eldredge
Faculty Publications
A tailsitter UAV has unique advantages over typical fixed wing aircraft or hovercraft. This paper highlights topics of interest in our preliminary research in developing a tailsitter UAV. An aerodynamic model and quaternion-based attitude and position control scheme is presented for controlling a tailsitter through hover maneuvers, with simulation results. Desired trajectories are also developed through feedback linearization of the dynamic equations, intended for quaternion-based attitude control. Finally, a hardware platform is proposed.
Techniques In The Design Of Thermomechanical Microactuators, Larry L. Howell, Timothy W. Mclain, Michael S. Baker, Christian D. Lott
Techniques In The Design Of Thermomechanical Microactuators, Larry L. Howell, Timothy W. Mclain, Michael S. Baker, Christian D. Lott
Faculty Publications
The purpose of this chapter is to provide fundamental background for the design of thermomechanical microactuators. Actuation has been a particularly challenging aspect of microsystem development. Many actuation approaches used at the macro level, such as hydraulics, pneumatics, electric motors, internal combustion engines and turbines, are either too difficult to fabricate at the micro level or do not work well at that scale. Electrostatic attraction is one approach that has been widely used for actuation of microsystems; however, electrostatic actuators tend to have high voltage requirements and low output force capabilities. While electrostatic actuation is suitable for many applications, some …