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Anxiety-Like Behavior In C57bl/6j And Dba/2j Mice: Pharmacological Characterization Of The Elevated Zero Maze And The Influence Of Age-Related Differences On Behavior, Timothy James Flanigan

Electronic Theses and Dissertations

Anxiety disorders affect a significant proportion of the population and can be debilitating in some circumstances. The exact etiology of these disorders remains to be determined and animal models are an important part of that effort. The elevated zero maze, a behavioral measure of anxiety, was introduced as an alternative to the popular elevated plus maze. While the elevated zero maze has been pharmacologically validated in rats, the available data in mice is more limited. Similarly, the data available on anxiety-like behavior in adolescent mice lacks breadth despite considerable evidence suggesting that developmental processes during this period play a role …