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Attenuated Effects Of Opiates In Adolescent Vs. Adult Male Rats: Reinforcement, Relapse, And Withdrawal, James M. Doherty
Attenuated Effects Of Opiates In Adolescent Vs. Adult Male Rats: Reinforcement, Relapse, And Withdrawal, James M. Doherty
Neuroscience Institute Dissertations
Adolescence in humans is a vulnerable period for illicit drug use, and teenage onset of drug use is associated with long-term addiction. Adolescent sensitivity to drug reinforcement, relapse, and withdrawal has not been explored thoroughly in animal models, especially considering opiate drugs such as morphine and heroin. The present series of studies profiles adolescent sensitivity to opiates using adolescent and adult male rats to test for age differences in opiate self-administration, reinstatement, withdrawal signs, locomotor sensitization, and even brain activation during drug-seeking. To test for acute sensitivity to the reinforcing effects of morphine or heroin, we compared patterns of self-administration …
Neuroendocrine Consequences Of Binge Alcohol Exposure During Peri-Puberty On Functioning Of The Hypothalamo-Pituitary-Adrenal (Hpa) Axis, Magdalena Malgorzata Przybycien-Szymanska
Neuroendocrine Consequences Of Binge Alcohol Exposure During Peri-Puberty On Functioning Of The Hypothalamo-Pituitary-Adrenal (Hpa) Axis, Magdalena Malgorzata Przybycien-Szymanska
Dissertations
Binge alcohol (EtOH) exposure in adolescence is a fundamental health concern. In 2005, over 20% of teenagers between ages 15 and 17 reported binge drinking behavior within a one month period preceding the survey (Dept. of Health and Human Services: Substance Abuse and Mental Health Services Administration). Binge drinking is defined as consuming enough alcohol within a 2.0 h period to bring blood alcohol concentration above 0.08%. In the adolescent population, this type of alcohol exposure tends to be repeated. In adults, alcohol abuse has been correlated with increased incidence of mood disorders and these disorders are characterized by dysregulation …