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Deep Learning Frameworks For Accelerated Magnetic Resonance Image Reconstruction Without Ground Truths, Ibsa Kumara Jalata

Graduate Theses and Dissertations

Magnetic Resonance Imaging (MRI) is typically a slow process because of its sequential data acquisition. To speed up this process, MR acquisition is often accelerated by undersampling k-space signals and solving an ill-posed problem through a constrained optimization process. Image reconstruction from under-sampled data is posed as an inverse problem in traditional model-based learning paradigms. While traditional methods use image priors as constraints, modern deep learning methods use supervised learning with ground truth images to learn image features and priors. However, in some cases, ground truth images are not available, making supervised learning impractical. Recent data-centric learning frameworks such as …

Temperature Mapping Using Mid-Field Magnetic Resonance Imaging, Diego F. Martinez

Electronic Thesis and Dissertation Repository

Magnetic Resonance Imaging (MRI) is a non-invasive imaging modality with excellent soft tissue contrast and sensitivity to tissue temperature. MRI use is growing in Canada with expectation that this is expected to continue in the medium term, with more wide adoption of MRI and in particular a renewed focus on MR systems which deviate from the most commonly used 1.5T field strength system. By implementing systems which do not use as strong magnets and instead operate

Generally, as the field strength of an MR system decreases, the signal received when imaging also decreases, which makes it difficult to implement some …

Neural Correlates Of Post-Traumatic Brain Injury (Tbi) Attention Deficits In Children, Meng Cao

Dissertations

Traumatic brain injury (TBI) in children is a major public health concern worldwide. Attention deficits are among the most common neurocognitive and behavioral consequences in children post-TBI which have significant negative impacts on their educational and social outcomes and compromise the quality of their lives. However, there is a paucity of evidence to guide the optimal treatment strategies of attention deficit related symptoms in children post-TBI due to the lack of understanding regarding its neurobiological substrate. Thus, it is critical to understand the neural mechanisms associated with TBI-induced attention deficits in children so that more refined and tailored strategies can …

Advancements In Magnetic Resonance Image Guided Radiotherapy, Austen Curcuru

McKelvey School of Engineering Theses & Dissertations

Magnetic resonance image guided radiation therapy (MRgRT) devices are a recently developed technology that integrate the excellent soft tissue contrast and real-time imaging capabilities of MRI with a medical linear accelerator (Linac). This provides an unprecedented ability to guide and adapt radiation therapy treatments based on real-time cine imaging. However, the merging of these technologies has come with unique challenges. MRI lacks the geometric fidelity of computed tomography (CT). Spatial inaccuracies in MRI can result from magnetic field (B0) or center frequency variations, gradient-induced eddy currents, and magnetic field gradient imperfections (e.g., nonlinearities, poor calibration, concomitant fields, and unsatisfactory electronic …

In Vivo Multi-Modal Imaging Approaches For Cancer, Stem And Immune Cells, Nourhan Shalaby

Electronic Thesis and Dissertation Repository

Introduction: Molecular imaging allows for non-invasive longitudinal visualization of cellular functions in vivo. This area of research has provided better understanding of fundamental molecular and biochemical processes, enabled optimization of pre-clinical and clinical assessments for new treatments, and allowed for more accurate and early detection of many pathologies. Extensive research for novel imaging techniques and emerging technologies have rapidly advanced the field. However, an ideal single imaging modality or approach does not exist. Alternatively, multi-modal imaging approaches are commonly applied to overcome limitations of individual technologies. In this thesis, we design, develop, validate, and image various cell types using …

Building A Magnetosome-Like Nanoparticle For Magnetic Resonance Imaging, Qin Sun

Electronic Thesis and Dissertation Repository

With its superb spatial and temporal resolution, magnetic resonance imaging (MRI) has great potential to track cellular activities that define early stages of disease. To improve molecular imaging techniques, we are developing MRI reporter gene expression based on the magnetosome. In magnetotactic bacteria (MTB), magnetosome formation compartmentalizes iron biominerals in membrane-enclosed vesicles. We hypothesize that essential magnetosome proteins interact in any cell type to form rudimentary magnetosome-like nanoparticles, providing a genetically-controlled contrast agent for molecular MRI.

MTB genes mamE, mamB, mamI, and mamL were cloned from M. magneticum sp. AMB-1 genomic DNA by PCR and inserted into …

Novel 129xe Magnetic Resonance Imaging And Spectroscopy Measurements Of Pulmonary Gas-Exchange, Alexander M. Matheson

Electronic Thesis and Dissertation Repository

Gas-exchange is the primary function of the lungs and involves removing carbon dioxide from the body and exchanging it within the alveoli for inhaled oxygen. Several different pulmonary, cardiac and cardiovascular abnormalities have negative effects on pulmonary gas-exchange. Unfortunately, clinical tests do not always pinpoint the problem; sensitive and specific measurements are needed to probe the individual components participating in gas-exchange for a better understanding of pathophysiology, disease progression and response to therapy.

In vivo Xenon-129 gas-exchange magnetic resonance imaging (¹²⁹Xe gas-exchange MRI) has the potential to overcome these challenges. When participants inhale hyperpolarized ¹²⁹Xe gas, it …