Digital Commons Network^™

Human Resource Initiatives Addressing Factors Impacting Organizational Gender Stratification And Performance: A Computational Study, Ashlyn Paige Lowe

College of Science and Health Theses and Dissertations

Women remain underrepresented in the upper echelons of organizational management, which is known as organizational gender stratification (OGS). Individual processes, such as differential career choices between men and women, contribute to OGS, along with organizational processes, such as bias in performance appraisal evaluations. Furthermore, these factors hold implications for organizational workforce potential if promotion decisions depend on biased performance evaluations. The literature lacks an integration of these factors in examining their combinatorial dynamic effects, as well as an assessment of practical steps organizations can take to combat the cultivation of OGS. This study has two primary purposes. First, it examines …

Model-Based Deep Autoencoders For Characterizing Discrete Data With Application To Genomic Data Analysis, Tian Tian

Dissertations

Deep learning techniques have achieved tremendous successes in a wide range of real applications in recent years. For dimension reduction, deep neural networks (DNNs) provide a natural choice to parameterize a non-linear transforming function that maps the original high dimensional data to a lower dimensional latent space. Autoencoder is a kind of DNNs used to learn efficient feature representation in an unsupervised manner. Deep autoencoder has been widely explored and applied to analysis of continuous data, while it is understudied for characterizing discrete data. This dissertation focuses on developing model-based deep autoencoders for modeling discrete data. A motivating example of …

The Messy Nuclear Landscape: Using Fuzzy Cognitive Mapping To Explore Plausible Nuclear Disarmament Scenarios, Ryan M. Nixon

Graduate Program in International Studies Theses & Dissertations

Nuclear weapons are seemingly permanent fixtures in international relations. Although nuclear abolitionists and actors within the Nonproliferation Treaty (NPT) and the International Atomic Energy Agency (IAEA) have taken significant steps towards designing a world without nuclear weapons, the longstanding realist logic that suggests nuclear disarmament is nonviable has born more fruit. On the other hand, some proponents of realism have suggested global nuclear disarmament is feasible, given that certain international instabilities are stabilized and that special care is taken during diplomatic negotiations. This presents an opportunity to test these predictions using fuzzy cognitive mapping, a computational modeling technique that identifies …

Determination Of Optimal Parameter Estimates For Medical Interventions In Human Metabolism And Inflammation, Marcella Torres

Theses and Dissertations

In this work we have developed three ordinary differential equation models of biological systems: body mass change in response to exercise, immune system response to a general inflammatory stimulus, and the immune system response in atherosclerosis. The purpose of developing such computational tools is to test hypotheses about the underlying biological processes that drive system outcomes as well as possible real medical interventions. Therefore, we focus our analysis on understanding key interactions between model parameters and outcomes to deepen our understanding of these complex processes as a means to developing effective treatments in obesity, sarcopenia, and inflammatory diseases.

We develop …

Agent Based Model Of Cavitation In Spinal Cord Injury, Rahma Ahmed

Senior Projects Spring 2019

Annually, approximately 375,000 people suffer from spinal cord injury (SCI) worldwide and many SCI patients develop secondary health conditions such as respiratory, cardiovascular, and urinary/bowel complications which negatively impact their daily lives. SCI occurs when there is damage to the spinal cord resulting in decreased motor functions, decreased sensory functions, or paralysis. Days to weeks after initial impact, the lesion (area of injury) continues to increase in size in a process called progressive cavitation which demyelinates axons and inhibits effective axonal regeneration. In an in vitro model of progressive cavitation, Fitch et al. showed that activated macrophages cause cavities to …

The Role Of The Mechanical Environment On Cd117+ Endothelial Cell Angiogenesis, Patrick Link

Theses and Dissertations

Angiogenesis is a complex process coordinating cell migration, proliferation, and lumen formation. Changes to the microenvironment regulate angiogenesis through mechanotransduction and cytokine signals. In pulmonary hypertension, something in the process becomes abnormal, resulting in changes to the microenvironment and the formation of a glomerulus of dysfunctional capillaries, called a plexiform lesion. Endothelial cells, expressing CD117 (CD117+ EC clones) increase in the plexiform lesions of pulmonary hypertension, independent of pro-angiogenic VEGF signaling. We hypothesize that the mechanical environment and the macromolecular composition of the extracellular matrix, both, contribute to the aberrant angiogenesis. When we changed the mechanical environment, we changed the …