Digital Commons Network^™

Chinese Immigrants With Non-Insulin-Dependent Diabetes Mellitus: Nutritional Self-Management Approach, Winnie Manlai Wong

Student Theses, Dissertations and Capstones

Background: Chinese immigrants (CIs) with non-insulin dependent diabetes mellitus (NIDDM) generally have poor control in their diet regimen. Due to the variation in body mass, physiology, and cultural differences as compare with the general American population, special attention must be conducted in treating diabetes in Cis, emphasizing culturally sensitive care and nutrition therapy that acknowledge the differences. Purpose: The purpose of this project was to assess cultural challenges in self-management for CIs living with non-insulin dependent diabetes mellitus and evaluate the effectiveness of a diabetic nutritional self-management guide tailored to this population. Theoretical Framework: Havelock’s theory of change is a …

Gerrymandering And The Impossibility Of Fair Districting Systems, Danielle Degutz

Senior Projects Spring 2019

Voting district boundaries are often manipulated, or gerrymandered, by politicians in order to give one group of voters an unfair advantage over another during elections. To make sure a system of voting districts is not gerrymandered, the population size, the shape, and the voting efficiency of each party in each district should be taken into consideration. Following recent work of Boris Alexeev and Dustin G. Mixon, we discuss mathematical criteria for each of these three aspects, and we prove how problems arise when attempting to apply all three at once to a districting system--first to a simplified districting system and …

Numerical Simulations Of Premixed Flames Of Multi Component Fuels/Air Mixtures And Their Applications, Essa Kh I J Salem

Theses and Dissertations--Mechanical Engineering

Combustion has been used for a long time as a means of energy extraction. However, in the recent years there has been further increase in air pollution, through pollutants such as nitrogen oxides, acid rain etc. To solve this problem, there is a need to reduce carbon and nitrogen oxides through lean burning, fuel dilution and usage of bi-product fuel gases. A numerical analysis has been carried out to investigate the effectiveness of several reduced mechanisms, in terms of computational time and accuracy. The cases were tested for the combustion of hydrocarbons diluted with hydrogen, syngas, and bi-product fuel in …

Cortical Stimulation Mapping Of Heschl’S Gyrus In The Auditory Cortex For Tinnitus Treatment, Austin Huang

CMC Senior Theses

Tinnitus is the perception of sound in the absence of an actual sound stimulus. Recent developments have shifted the focus to the central nervous system and the neural correlate of tinnitus. Broadly, tinnitus involves cortical map rearrangement, pathological neural synchrony, and increased spontaneous firing rates. Various cortical regions, such as Heschl’s gyrus in the auditory cortex, have been found to be associated with different aspects of tinnitus, such as perception and loudness. I propose a cortical stimulation mapping study of Heschl’s gyrus using a depth and subdural electrode montage to conduct electrocorticography. This study would provide high-resolution data on abnormal …

Nonsense Mutation In Aimp2 Reduces Protein Expression And Causes A Severe Neurodevelopmental Disorder, Pryce Patterson

UVM Honors College Senior Theses

In mammalian cells, a multi-tRNA synthetase complex containing eight aminoacyl-tRNA synthetases, which catalyze nine different reactions, is thought to make protein synthesis more efficient by keeping components of the translational machinery in close proximity. Aminoacyl tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is one of three non-catalytic components of this complex and is essential for its formation and stability. A homozygous nonsense variant (Y35Ter) of AIMP2 appears in the genotypes of patients with severe neurodevelopmental phenotypes. To determine the effect this variant has on expression at the mRNA and protein level, as well as progression of cells through the cell cycle, …

Cost Effectiveness Analysis Of Enzalutamide, Abiraterone Plus Prednisone And Cabazitaxel Plus Predinsone For The Treatment Of Visceral Metastatic Castration Resistant Prostate Cancer (Mcrpc) After Docetaxel Therapy, Yazan K. Barqawi

Pharmaceutical Sciences ETDs

Background: Prostate cancer is the second leading cause of death after lung cancer among men in the US. The America Cancer Society predicts 164,690 new cases and 29,430 prostate cancer deaths in 2018. Of those diagnosed with prostate cancer, about 10-20 % will develop castration-resistant prostate cancer (CRPC) within 5 years of diagnosis and 70 % of those cases will metastasize to mCRPC. In 2014, nearly US $13.4 billion was spent on prostate cancer in the US and expected to reach US $15.4 billion by 2020; making prostate cancer the fifth most costly cancer.

Objective: To conduct a cost-effective analysis …

Domain Decomposition Methods For The Solution Of Multiple Scattering Problems, Michael Pedneault

Dissertations

This presents a Schur complement Domain Decomposition (DD) algorithm for the solution of frequency domain multiple scattering problems. Just as in the classical DD methods,(1) the ensemble of scatterers is enclosed in a domain bounded by an artificial boundary, (2) this domain is subdivided into a collection of nonoverlapping subdomains so that the boundaries of the subdomains do not intersect any of the scatterers, and (3) the solutions of the subproblems are connected via Robin boundary conditions matching on the common interfaces between subdomains. Subdomain Robin-to-Robin maps are used to recast the DD problem as a sparse linear system whose …

Wireless Coverage Using Unmanned Aerial Vehicles, Hazim Shakhatreh

Dissertations

The use of unmanned aerial vehicles (UAVs) is growing rapidly across many civilian application domains including real-time monitoring, search and rescue, and wireless coverage. UAVs can be used to provide wireless coverage during emergency cases where each UAV serves as an aerial wireless base station when the cellular network goes down. They can also be used to supplement the ground base station in order to provide better coverage and higher data rates for the users. During such situations, the UAVs need to return periodically to a charging station for recharging, due to their limited battery capacity. Given the recharging requirements, …

Impairments In Ground Moving Target Indicator (Gmti) Radar, Phuoc Doan Huu Vu

Dissertations

Radars on multiple distributed airborne or ground based moving platforms are of increasing interest, since they can be deployed in close proximity to the event under investigation and thus offer remarkable sensing opportunities. Ground moving target indicator (GMTI) detects and localizes moving targets in the presence of ground clutter and other interference sources. Space-time adaptive processing (STAP) implemented with antenna arrays has been a classical approach to clutter cancellation in airborne radar. One of the challenges with STAP is that the minimum detectable velocity (MDV) of targets is a function of the baseline of the antenna array: the larger the …

Optimizing Resource Allocation In Eh-Enabled Internet Of Things, Ali Shahini

Dissertations

Internet of Things (IoT) aims to bridge everyday physical objects via the Internet. Traditional energy-constrained wireless devices are powered by fixed energy sources like batteries, but they may require frequent battery replacements or recharging. Wireless Energy Harvesting (EH), as a promising solution, can potentially eliminate the need of recharging or replacing the batteries. Unlike other types of green energy sources, wireless EH does not depend on nature and is thus a reliable source of energy for charging devices. Meanwhile, the rapid growth of IoT devices and wireless applications is likely to demand for more operating frequency bands. Although the frequency …

Characterization Of Self-Heating Effects And Assessment Of Its Impact On Reliability In Finfet Technology, Peter Christopher Paliwoda

Dissertations

The systematically growing power (heat) dissipation in CMOS transistors with each successive technology node is reaching levels which could impact its reliable operation. The emergence of technologies such as bulk/SOI FinFETs has dramatically confined the heat in the device channel due to its vertical geometry and it is expected to further exacerbate with gate-all-around transistors.

This work studies heat generation in the channel of semiconductor devices and measures its dissipation by means of wafer level characterization and predictive thermal simulation. The experimental work is based on several existing device thermometry techniques to which additional layout improvements are made in state …

Load Balancing And Scalable Clos-Network Packet Switches, Oladele Theophilus Sule

Dissertations

In this dissertation three load-balancing Clos-network packet switches that attain 100% throughput and forward cells in sequence are introduced. The configuration schemes and the in-sequence forwarding mechanisms devised for these switches are also introduced. Also proposed is the use of matrix analysis as a tool for throughput analysis.

In Chapter 2, a configuration scheme for a load-balancing Clos-network packet switch that has split central modules and buffers in between the split modules is introduced. This switch is called split-central-buffered Load-Balancing Clos-network (LBC) switch and it is cell based. The switch has four stages, namely input, central-input, central-output, and output stages. …

The Cooperative Effects Of Channel Length-Bias, Width Asymmetry, Gradient Steepness, And Contact-Guidance On Fibroblasts’ Directional Decision Making, Quang Long Pham

Dissertations

Cell migration in complex micro-environments, that are similar to tissue pores, is important for predicting locations of tissue nucleation and optimizing scaffold architectures. Firstly, how fibroblast cells - relevant to tissue engineering, affect each other’s directional decisions when encountered with a bifurcation of different channel lengths was investigated. It was found that cell sequence and cell mitosis influence the directional choices that the cells made while chemotaxing. Specifically, the fibroblasts chose to alternate between two possible paths - one longer and the other shorter - at a bifurcation. This finding was counter-intuitive given that the shorter path had a steeper …

Magnetic Field Assisted Milli-Scale Robotic Assembly Machine: An Approach To Massively Parallel Swarm Robotic Automation Systems, Yan Liu

Dissertations

The vision of highly parallel, automated manufacturing systems that can build macroscopic products by heterogeneous assembly of many small devices will have a major impact in manufacturing. In this study, a novel milli-scale robotic assembly machine with parallel capabilities, assisted with programmable magnetic field, is developed. The machine prototype consists of a 16x16 array of electromagnets. The dimensions of the electromagnets are 5mm high with an inner diameter of 1.1mm and outer diameter of 2.5mm. All the electromagnets are driven by a 16x16 array of H-Bridges, and an Arduino microcontroller is used to control and program the arrays.

Using the …

Storage Systems For Mobile-Cloud Applications, Nafize R. Paiker

Dissertations

Mobile devices have become the major computing platform in todays world. However, some apps on mobile devices still suffer from insufficient computing and energy resources. A key solution is to offload resource-demanding computing tasks from mobile devices to the cloud. This leads to a scenario where computing tasks in the same application run concurrently on both the mobile device and the cloud.

This dissertation aims to ensure that the tasks in a mobile app that employs offloading can access and share files concurrently on the mobile and the cloud in a manner that is efficient, consistent, and transparent to locations. …

Methods To Improve The Remediation Of Polycyclic Aromatic Hydrocarbons (Pahs) In Aerobic And Anaerobic Environments, Brian Wartell

Dissertations

Oil spills occur regularly in terrestrial environments and crude oil can contain many compounds that are highly resistant to degradation. Among these compounds are high levels of polycyclic aromatic hydrocarbons (PAHs) which are not only toxic but can also be carcinogenic and/or mutagenic. The first chapter of this dissertation includes an extensive review chapter on the variables affecting the anaerobic degradation of hydrocarbons, with a particular focus on PAHs. Electron acceptors, electron donors, temperature, salinity, pH all play key roles in determining the possibility effective of effective degradation occurring. Thus, by addressing solutions, such as biostimulation, improving environmental variables for …

High-Speed Data Communications For Vehicular Networks Using Free-Space Optical Communications, Yagiz Kaymak

Dissertations

The demand for high-speed Internet access for vehicles, such as high-speed trains (HSTs) and cars, is on the rise. Several Internet access technologies that use radio frequency are being considered for vehicular networking. Radio-frequency communications technologies cannot provide high data rates due to interference, bandwidth limitations, and the inherent limited data rates of radio technology. Free-space optical communications (FSOC) is an alternative approach and a line-of-sight (LOS) technology that uses modulated light to transfer data between two free-space optical (FSO) transceivers. FSOC systems for vehicular networks are expected to provide data rates in the range of Gbps for stationary and …

Experimental And Numerical Characterization Of Multiphase Subsurface Oil Release, Feng Gao

Dissertations

Subsurface oil release is commonly encountered in the natural environment and engineering applications and has received the substantial attention of researchers after the disastrous Deepwater Horizon Blowout oil spill in 2009. The main focus on the present research is to systematically study the hydrodynamics of underwater oil jet under a variety of conditions, including the effect of dispersant and different gas to oil ratios (GOR) by using experimental measurement as well as a Computational Fluid Dynamics (CFD) approach, from which the measured turbulent characteristics (e.g., velocity, turbulent kinetic energy, turbulence dissipation rate, etc.) of underwater oil jet are thoroughly examined …

Fwer Controlling Procedures In Simultaneous And Selective Inference, Li Yu

Dissertations

With increasing complexity of research objectives in clinical trials, a variety of relatively complex and less intuitive multiple testing procedures (MTPs) have been developed and applied in clinical data analysis. In order to make testing strategies more explicit and intuitive to communicate with non-statisticians, several flexible and powerful graphical approaches have recently been introduced in the literature for developing and visualizing newer MTPs. Nevertheless, some theoretical as well as methodological issues still remain to be fully addressed. This dissertation addresses several important issues arising in graphical approaches and related selective inference problems. It consists of three parts.

In the first …

Functionalized Carbon Nanotubes In Hydrophobic Drug Delivery, Kun Chen

Dissertations

The direct incorporation of carboxylated carbon nanotubes (f-CNTs) into hydrophobic drug particles during their formation via anti-solvent precipitation is presented. The approach is tested using two drugs namely antifungal agent Griseofulvin (GF) and antibiotic Sulfamethoxazole (SMZ) that have very different aqueous solubility. It is observed that the f-CNTs dispersed in the water serve as nucleating sites for crystallization and are readily incorporated into the drug particles without altering crystal structure or other properties. The results show that the hydrophilic f-CNTs dramatically enhance dissolution rate for both drugs. The increased degree of functionalization leads to higher hydrophilicity and therefore faster dissolution …

Deep Learning Methods For Mining Genomic Sequence Patterns, Xin Gao

Dissertations

Nowadays, with the growing availability of large-scale genomic datasets and advanced computational techniques, more and more data-driven computational methods have been developed to analyze genomic data and help to solve incompletely understood biological problems. Among them, deep learning methods, have been proposed to automatically learn and recognize the functional activity of DNA sequences from genomics data. Techniques for efficient mining genomic sequence pattern will help to improve our understanding of gene regulation, and thus accelerate our progress toward using personal genomes in medicine.

This dissertation focuses on the development of deep learning methods for mining genomic sequences. First, we compare …

Overcoming Conventional Modeling Limitations Using Image- Driven Lattice-Boltzmann Method Simulations For Biophysical Applications, Olufemi E. Kadri

Dissertations

The challenges involved in modeling biological systems are significant and push the boundaries of conventional modeling. This is because biological systems are distinctly complex, and their emergent properties are results of the interplay of numerous components/processes. Unfortunately, conventional modeling approaches are often limited by their inability to capture all these complexities. By using in vivo data derived from biomedical imaging, image-based modeling is able to overcome this limitation.

In this work, a combination of imaging data with the Lattice-Boltzmann Method for computational fluid dynamics (CFD) is applied to tissue engineering and thrombogenesis. Using this approach, some of the unanswered questions …

Cardiac Regenerative Medicine: Insights From Healthy And Diseased Engineered Tissues, Pamela Grace Hitscherich

Dissertations

Cardiovascular disease remains the leading cause of mortality in the United States. Current tissue engineering approaches have fallen short of promoting fully functional cardiovascular cells and the post-myocardial infarction microenvironment is still not well understood. These gaps in knowledge are addressed in this dissertation through the development of in vitro engineered cardiac tissues using electroactive materials to enhance the differentiation of pluripotent stem cell derived cardiomyocytes and through the development of in vitro myocardial inflammation models dedicated to understanding cardiomyocytes and macrophages interactions.

Specifically, piezoelectric poly (vinylidene fluoride-trifluoroethylene) (PVDF-TrFE) supports the attachment and survival of mouse embryonic stem cell derived …

Individual’S Self Awareness Of Mental Illness: The Effects On Implicit Bias, Microaggressions, And Racial Discrimination, Sarah Zoubaa

Student Theses

The purpose of the current study is to understand the factors that impact how persons experiencing subclinical psychological symptoms or an undiagnosed but clinically significant psychological problem perceive individuals who been diagnosed with mental illness. Previous literature has investigated the experiences of discrimination among those with mental health problems, but not their attitudes and behavior towards individuals among their in-group. It was hypothesized that individuals with an emerging mental health problem will have higher rates of implicit bias and perpetrate more microaggressions towards those with a mental illness in order to remove themselves from a group that is associated with …

“I’M The Greatest”: Pride, Impression Management, And Denial Of Coercive Control And Physical Abuse By Perpetrators Of Intimate Partner Violence, Benjamin Reissman, Kendra Doychak M.A., Angela Crossman Ph.D., Chitra Raghavan Ph.D.

Student Theses

Coercive control and physical abuse are two prominent forms of intimate partner violence (IPV), often accompanied by with impression management to conceal such behavior. However, intrinsic motives for engaging in impression management by male IPV offenders are not well-known. The present study makes use of archival data from 85 heterosexual men in a batterer treatment program to gauge how pride, shame, and guilt may relate to impression management and reported IPV. Admission to shame and guilt appear to be correlated with and predictive of both forms of reported abuse, along with the absence of impression management. This implies that internalized …

Analysis Of 3d Printed Ndfeb Polymer Bonded And Organic Based Magnets, Chimaobi Ibeh

Theses

Additive manufacturing (AM), or commonly known as 3D printing, has introduced to the manufacturing and commercial sectors novel ways of reducing production times, decreasing material waste, and enabling end products with multi-material configuration and complex geometric designs. From industrial scale to customer-based printers, AM has revolutionized the approach to manufacturing, prototyping, and designing in the field of medical, automotive, aerospace, biomedical, electronics and customizable products. Recently, additive manufacturing has crossed over to the area of applications in magnetism due to the economic push for the miniaturization of electronic and mechanical devices, reduction in production costs and material & design flexibility. …

Icing Thickness Prediction Model For Overhead Transmission Lines, Yue Ming

Theses

Failures in a large electric power system are often inevitable. Severe weather conditions are one of the main causes of transmission line failures. Using the fault data of transmission lines of Shaanxi Power Grid from 2006 to 2016, in conjunction with meteorological information, this paper analyses the relationship between the temporal-spatial distribution characteristics of meteorological disasters and the fault of transmission lines in Shaanxi Province, China.

In order to analyze the influence of micro-meteorology on ice coating, a grey correlation analysis method is proposed. This thesis calculates the grey relational between ice thickness and micro-meteorological parameters such as ambient temperature, …

Polya Db3: A Database Cataloging Polyadenation Sites(Pas) Across Different Species And Their Conservation, Ram Mohan Nambiar

Theses

Polyadenation is an important process occurring in the messenger RNA that involves cleavage of 3 end nascent mRNAs and addition of poly(A) tails. For this thesis,I present PolyA DB3 ,a database cataloging cleavage and polyadenylation sites (PASs) in several genomes specifically for human,mouse,rat and chicken. This database is based on deep sequencing data. PASs are mapped by the 3’ region extraction and deep sequencing (3’READS) method, ensuring unequivocal PAS identification. Large volume of data based on diverse biological samples is used to increase PAS coverage and provide PAS usage information. Strand-specific RNA-seq data were used to extend annotated 3’ ends …

Interactions Between Polymer Nanoparticles And Blood Plasma Applied To Drug Delivery Systems, Mark Bannon

Theses

Targeted nanoparticle drug delivery has the potential to replace current forms of cancer therapy with previously unparalleled efficiency. Upon introduction into the human body, nanoparticles exhibit a substantial increase in diameter due to a biomolecular corona formation caused by interactions between blood plasma proteins and the nanoparticles. These interactions must be analyzed and understood for targeted delivery to reach its potential in both feasibility and efficiency.

To study the formation of the protein corona, polystyrene nanoparticles were incubated in vitro in goat blood plasma for 10-minute intervals, diluted to different degrees and then measured to obtain the hydrodynamic diameter of …

Computational Intelligence In Steganography: Adaptive Image Watermarking, Xin Zhong

Dissertations

Digital image watermarking, as an extension of traditional steganography, refers to the process of hiding certain messages into cover images. The transport image, called marked-image or stego-image, conveys the hidden messages while appears visibly similar to the cover-image. Therefore, image watermarking enables various applications such as copyright protection and covert communication. In a watermarking scheme, fidelity, capacity and robustness are considered as crucial factors, where fidelity measures the similarity between the cover- and marked-images, capacity measures the maximum amount of watermark that can be embedded, and robustness concerns the watermark extraction under attacks on the marked-image. Watermarking techniques are often …