Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Entire DC Network
Mucin Associated Surface Protein Synthetic Peptide As A Novel Vaccine Candidate Against Chagas Disease, Carylinda Serna
Mucin Associated Surface Protein Synthetic Peptide As A Novel Vaccine Candidate Against Chagas Disease, Carylinda Serna
Open Access Theses & Dissertations
Trypanosoma cruzi is an intracellular protozoan parasite and the etiological agent for Chagas disease. Chagas is endemic in Latin America affecting 18-20 million people. However, currently worldwide increasing numbers of the disease are being seen due to migration and globalization. This neglected disease causes significant morbidity, mortality, and an economic burden. There are no known vaccines and the only currently available drug is Benznidazole, but its effects are controversial. Nonetheless, a therapeutic or prophylactic vaccine is of urgent need to alleviate this disease. In this study we present an experimental approach using a synthetic peptide-based vaccine against T. cruzi. The …
Automatic Elucidation Of Gpi Molecular Structures With Grid Computing Technology, Juan Clemente Aguilar Bonavides
Automatic Elucidation Of Gpi Molecular Structures With Grid Computing Technology, Juan Clemente Aguilar Bonavides
Open Access Theses & Dissertations
Glycosylphosphatidylinositol (GPI)-anchored proteins are involved in many biological processes and are of medical importance. The identification and analysis of the entire collection of free and protein-linked GPIs within an organism (i.e., GPIomics) requires highly sensitive instruments. At present, liquid chromatography-tandem mass spectrometry (LC-MS/MS or -MSn) is the most efficient laboratory technique for these tasks. As a typical MSn experiment produces hundreds of thousands of spectra, the data analysis creates a major bottleneck in high-throughput GPIomic projects. Yet, no computational tool for characterizing the chemical structures of GPI is available to date. We propose a library-search algorithm to …
Identification Of Chemotherapeutic Agents Against Leishmaniasis And Chagas' Disease, Miguel Abran Vasquez
Identification Of Chemotherapeutic Agents Against Leishmaniasis And Chagas' Disease, Miguel Abran Vasquez
Open Access Theses & Dissertations
Patients with clinical manifestations of leishmaniasis and Chagas' disease rely on few drugs that have limited efficacy and considerable side effects. Expanding the diversity of available chemotherapeutic drugs for these diseases is of extreme medical importance. Enones or á,í¢-unsaturated ketones, initially developed as anti-cancer agents, are a worthy of class of compounds to test for activity against Leishmania major and Trypanosoma cruzi as these eukaryotic parasites share many of the characteristics exhibited by cancer cells. The anti-parasitic activity of a library of á,í¢-unsaturated ketones (136 derivatives) was screened against L. major as well as in mammalian cells. Three compounds (NC901, …