Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Entire DC Network
The Role Of Nitric Oxide In Pancreatic Cell Secretion, Kaylee R. Walters
The Role Of Nitric Oxide In Pancreatic Cell Secretion, Kaylee R. Walters
Honors Capstones
The pancreas is a model tissue that has been extensively studied in the lab of my research supervisor. They have shown that nitric oxide is produced by the pancreas and is necessary for sectretion; however, the mechanism of action remained to be identified. The goal of my research over the past year was to investigate the signaling role of nitric oxide, the peroxynitrite producing enzyme NADPH oxidase NOX-4, and the nitrosylation oftarget proteins on the zymogen granule membrane as a potential mechanism to regulate cytoskeletal reorganization and migration of the secretory vesicles. In addition, I performed research to understand the …
The Role Of Nck In Pancreatic Secretion, Cole Lightfoot
The Role Of Nck In Pancreatic Secretion, Cole Lightfoot
Honors Capstones
In the body, secretion is a vital process providing the release of many different and important macromolecular compounds. Using the pancreas as a model secretory organ, research was conducted pertaining to pancreatic exocytosis and the signal transduction system that controls it. The specific focus of the research is to better understand the role of Nck, a ubiquitous adaptor protein, in cytoskeleton reorganization and pancreatic secretion. The goal of the experiments conducted is to prove that upon stimulation of pancreatic acinar cells, Nck recruits to the secretory vesicles. Nck facilitates protein-protein interactions and acts as a regulator of cytoskeletal activation-dependent processes. …
Gorwth And Developmental Plasticity Of Chaoborus Americanus Populations, Rachel Moran
Gorwth And Developmental Plasticity Of Chaoborus Americanus Populations, Rachel Moran
Honors Capstones
The larval stage of the phantom midge Chaoborus americanus (Chaoboridae) is an important predator on zooplankton in temperate, fish less ponds. Chaoborus have distinct development stages typical of holometabolous insects: egg, larva (four larval instars), pupa, and adult. Temperature and food levels can significantly affect development rates in insects. The purpose of this study was: (1) to compare developmental patterns of populations of C. americanus from different latitudes (northern Wisconsin, northern Illinois), which experience different annual temperature regimes; and (2) to construct a mathematical model to predict larval development patterns (Developmental Model) and another to predict abundance patterns for C. …
Isolation And Analysis Of Arabidopsis Thaliana Lines Bearing Drg Knock-Out Mutations And Overexpressing Gfp Protein Fusions: Are Wild-Type Drgs Necessary For Heat Stress Granule Formation?, Lindsey Mckinney
Honors Capstones
Purpose and Methodology: The purpose of this study was to determine the role of DRG and GFP in response to heat stress in Arabidopsis by examining whether any DRG mutant combination inhibits the formation of heat stress granules (HSGs) following exposure of plants to heat stress. Methods utilized in the experimentation include the polymerase chain reaction (PCR) and gel electrophoresis to screen for plants containing the desired combination of genes, a root-growth assay to study the relationship between phenotype and genetic composition, and confocal microscopy to observe the formation of HSGs in root tips. Findings: The genetic composition of DRG …