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Solid Phase Amide Synthesis Using Staudinger-Vilarrasa Coupling And Microwave Irradiation, Ryan Patrick Schmidtz
Solid Phase Amide Synthesis Using Staudinger-Vilarrasa Coupling And Microwave Irradiation, Ryan Patrick Schmidtz
Undergraduate Honors Thesis Collection
Amide bond formation is an already well documented area of organic chemistry, and is very useful in its application in medicine and pharmaceuticals. However, current methods have not been investigated with regards to optimization of reaction times, solvents, and energy sources. In addition, current methods also utilize toxic solvents to cleave the peptide from the solid phase resin. In our study, we combine the Staudinger and Vilarrasa coupling reactions with microwave irradiation to develop and optimize the synthesis of amide bonds through the use of a solid support. Instead of attaching the peptide to the solid support, our amide bond …
Investigating Ring Closing Metathesis Product Favorability By Varying The Alkyne Substituent On A Dienyne, Meagan E. Hinze
Investigating Ring Closing Metathesis Product Favorability By Varying The Alkyne Substituent On A Dienyne, Meagan E. Hinze
Undergraduate Honors Thesis Collection
Diene metathesis, which is also known as an olefin metathesis, has been very important for the development of synthetic strategies in organic chemistry since it's inception in the 1950s. The olefin metathesis reaction is when two alkenes exchange the carbons on their double bonds, thus producing two new carbon□arbon double bonds.
Optimization Of A Polydimethylsiloxane Based Passive Sampler Of Common Household Volatile Organic Compounds, Jennifer Lynn Osborne
Optimization Of A Polydimethylsiloxane Based Passive Sampler Of Common Household Volatile Organic Compounds, Jennifer Lynn Osborne
Undergraduate Honors Thesis Collection
Dangerous volatile organic compounds, or VOCs, can accumulate as indoor air pollution within homes causing health problems in the habitants. In order to determine the concentration of VOCs in such areas a field-deployable sampler is necessary. The focus of this work has been to develop an inexpensive, reusable, sensitive fielddeployable passive sampler for monitoring VOCs in indoor air. We have devised a sampler that uses polydimethylsiloxane (PDMS), which is a common inexpensive, nonpolar adsorbent. The sampler is comprised of an aluminum bottle coated with the PDMS. In operation, the coated portion is exposed to the air to be sampled. The …
Liquid Carbon Dioxide Extraction Of Various Food Flavors: Evaluation And Analysis, Deven Lee Shinholt
Liquid Carbon Dioxide Extraction Of Various Food Flavors: Evaluation And Analysis, Deven Lee Shinholt
Undergraduate Honors Thesis Collection
Sub- and supercritical carbon dioxide has been utilized as an extraction solvent for a variety of natural compounds. This requires the use of specialized high-pressure vessels. It was reported recently that common laboratory apparatus (centrifuge tubes) could be utilized in liquid carbon dioxide extractions obviating the need for specialized equipment. Various herbs and spices (including orange, lemon, lime, and grapefruit zest, oregano, rosemary, sage, spearmint, nutmeg, black peppercorns, cloves, caraway seeds, and vanilla beans) were used as substrates for liquid carbon dioxide extractions by this straightforward technique. The extracted oils, containing terpenes and terpenoids, were then analyzed through GC/MS. Liquid …