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Studies Of The Effects Of Pancreatic Beta Cell Antioxidant Transgenes On Experimental Models Of Diabetes., Hainan Chen

Electronic Theses and Dissertations

Pancreatic beta cells are extremely vulnerable to the destruction of Reactive Oxygen Species (ROS). In both type 1 and type 2 diabetes ROS are involved in the loss of U+000DF-cells. We hypothesized that the deficiency in ROS detoxifying system of U+000DF-cells resulted in U+000DF-cell vulnerability and enhanced ROS protection would protect from diabetes. To test this hypothesis, transgenic mice with overexpression of U+000DF-cell antioxidant protein metallothionein (MT), manganese superoxide dismutase (MnSOD) and catalase were produced on an FVB background. Initial studies demonstrated that these transgenes did not affect U+000DF-cell normal function and morphology. But those transgenes significantly protected pancreatic islets …

Perceptions Of Parental Differential Treatment: Correlates In Chronically Ill And Non-Ill Samples Of Children, Julie A. Reich

USF Tampa Graduate Theses and Dissertations

We studied perceptions parental differential treatment as reported by parents and children in two different settings. Perceptions of differential affection and control were examined in healthy families and in families that include a child diagnosed with Type 1 diabetes. Parental differential treatment was assessed using questionnaires that measured perceptions of absolute parenting for children and their siblings. Difference scores were subsequently utilized to generate perceived parental differential treatment scores. Participants were 61 parents (half with healthy children, half with one child who has diabetes) and 62 children (half comprising sibling pairs unaffected by any medical problems, half including one child …

Increasing Diabetes Awareness In Adolescents Through Educational Programs., Sandra J. Reese

Electronic Theses and Dissertations

The purpose of this study was to increase knowledge of diabetes and promote healthy lifestyle behaviors to reduce diabetes onset in a community with a relatively high incidence of type 2 diabetes. Three hundred eighty seven students grades 7 – 12 participated in the program and taste test. Changes in knowledge before and after an educational program focusing on diabetes prevention were measured by comparison of identical pre, post, and retention tests. Students were also asked to name specific behaviors they could use to decrease the risk of diabetes. Responses were analyzed using Chi square analysis and content analysis. Overall, …

Effects Of Diabetes And Aging On Posture And Acceleration Thresholds During Lateral Translations, Samantha Jean Richerson

Doctoral Dissertations

Research objectives. One source of falls in the elderly may be an inability to sufficiently adjust to transient postural perturbations or slips. Identifying useful predictors of fall potential, as well as factors that affect the ability of an individual to detect a movement of the standing support surface may provide insight into postural stability and methods to increase stability in elders. To do this, acceleration thresholds to short, precise, lateral platform translations and the resultant psychophysical responses of adults with early Type 2 diabetes to age-matched controls and young adults were measured.

Methods. Using an innovative SLIP-FALLS platform, …

Adherence To Medical Regimens In Low-Income Adults With Type 2 Diabetes: The Influence Of Perceived Control Constructs, Erin L. O'Hea

LSU Doctoral Dissertations

Individuals with Type 2 diabetes often do not adhere to their treatment regimens (e.g., exercise, diet, medication, glucose monitoring). Non-adherence results in poor metabolic control, further morbidity and mortality, and increased health care utilization and costs. One common thread among many health-behavior-theories that attempt to explain non-adherence behaviors is the importance of perceived control. This psychosocial variable has most often been conceptualized as ‘health locus of control,’ which refers to the belief that one has the ability to influence or change one’s health outcomes. Inconsistent findings have been reported regarding the relationship of health locus of control and medical regimen …