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On Gene Prediction By Cross-Species Comparative Sequenced Analysis., Rong Chen

Student Work

The availability of large fragments of genomic DNA makes it possible to apply comparative genomics for identification of protein-coding regions. We have conducted a comparative analysis of homologous genomic sequences of organisms with different evolutionary distances and found the conservation of the non-coding regions between closely related organisms. In contrast, more distance shows much less intron similarity but less conversion on the exon structures. We sought to illuminate the impact of evolutionary distances on the performance of our gene-finding program based on the cross-species sequence comparison. Based on our finding and training of data sets, we proposed a model by …