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Alterations In Calcium Homeostasis And The Insulin-Like Growth Factor Signaling Pathway Induced By Carcinogenic Polycyclic And Halogenated Aromatic Hydrocarbons In Human Mammary Epithelial Cells, Stacey L. Tannheimer
Alterations In Calcium Homeostasis And The Insulin-Like Growth Factor Signaling Pathway Induced By Carcinogenic Polycyclic And Halogenated Aromatic Hydrocarbons In Human Mammary Epithelial Cells, Stacey L. Tannheimer
Pharmaceutical Sciences ETDs
Breast cancer is a major health concern for women, with only a small percent of the risk factors currently identified. It has been estimated that environmental factors may contribute to up to 80% of breast cancer cases. Many environmental carcinogens, such as polycyclic and halogenated aromatic hydrocarbons (PAHs and HAHs), are proven mammary carcinogens in animal models. Therefore, these studies were conducted to elucidate potential roles of PAHs and HAHs in alterations in known signaling pathways in human mammary epithelial cells (HMEC). Carcinogenic PAHs have previously been shown to produce sustained alterations in the calcium (Ca2') homeostasis of lymphocytes Therefore, …
Coping Mechanisms Utilized By Women Survivors Of Breast Cancer, Elizabeth Polk Thomas
Coping Mechanisms Utilized By Women Survivors Of Breast Cancer, Elizabeth Polk Thomas
MSN Research Projects
The suspected and confirmed diagnosis of breast cancer evokes feelings of fear, anxiety, guilt, frustration, and vulnerability in an individual. A woman diagnosed with breast cancer may utilize a variety of coping mechanisms. This descriptive study sought to identify the most common and most effective coping mechanisms utilized by women survivors of breast cancer answering the following research question: Which coping mechanisms are most effective and most frequently utilized by women survivors of breast cancer? This study used the theory of Lazarus and Folkman (1984) as a framework for understanding coping. The final sample (N = 20) consisted of women …
The Cellular And Molecular Dynamics Of The Queuosine Modification In Transfer Rna: Definition, Modulation, Deficiencies And Effect Of The Queuosine Modification System, Rana C. Morris
Theses and Dissertations in Biomedical Sciences
The presence of the queuosine modification in the wobble position of tRNAasn, tRNasp, tRNAhis, and tRNAtyr is associated with a decrease in cellular growth rate, an increase in the ability to withstand environmental stress, and differentiation of pleuripotent cells into mature phenotypes. The loss of this normal modification is strongly correlated with neoplastic transformation and tumor progression of a wide variety of cancers.
The "normal" system for formation of the queuosine modification in tRNA was studied in human fibroblast cell cultures and in mouse, rat and human liver tissues. The queuosine modification system …
Leadership And The Breast Cancer Movement, Amy Silverstein
Leadership And The Breast Cancer Movement, Amy Silverstein
Honors Theses
The breast cancer movement stays away from power struggles and superiority complexes. These women figured out that in order to stay organized and in control, every woman needed to feel included. The nature of the issue of the movement helps as well. Since most of these women fought the disease either themselves or with others, they understand how important a supportive environment contributes to a person's well-being. This support flows into the movement and contributes to the sense of togetherness. Some women are more prone to leadership than others, but that does not mean that they are somehow superior. Their …
What Is The Intimate Experience Of Couples Following The Woman's Cancer-Related Breast Surgery?, Lynne Amor
What Is The Intimate Experience Of Couples Following The Woman's Cancer-Related Breast Surgery?, Lynne Amor
Theses: Doctorates and Masters
The purpose of this phenomenological study is to describe and interpret the experience of couples following the woman's surgery for breast cancer, in order to gain an in depth understanding of how this mutilating surgery affects their everyday lives. Breast cancer is the most prevalent form of cancer in Australian women, and in most industrialised nations. Women in Australia have a one in fourteen lifetime risk of developing the disease. Little is known concerning what meanings this surgery brings to the intimacy experienced between partners. It is important to seek knowledge of the phenomenon of intimacy, how the couples understand …