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Investigating The Role Of Dna Polymerase Beta In The Aging Phenotype Of Down Syndrome, Aqila Ahmed Ahmed
Investigating The Role Of Dna Polymerase Beta In The Aging Phenotype Of Down Syndrome, Aqila Ahmed Ahmed
Wayne State University Dissertations
Down syndrome (DS) is a chromosomal condition characterized by accelerated aging that has yet to be directly linked to a DNA repair defect. Reduced PolB and unrepaired damage from oxidative stress observed in DS, point toward defective base excision repair (BER). In this study, we report that low PolB transcript correlates with increased markers of senescence. The gene dosage effect of Trisomy 21 is likely the source for PolB downregulation. We show that the HSA21-localized miR-155 overexpression correlates with a decrease in Creb1 and PolB, thus establishing a putative regulatory pathway. Data from the DS mouse model, Ts65Dn, reveal low …
The Impact Of Age On Workplace Motivation: A Person-Centered Perspective, Keith Lynn Zabel
The Impact Of Age On Workplace Motivation: A Person-Centered Perspective, Keith Lynn Zabel
Wayne State University Dissertations
The present study used the person-centered approach to examine how profiles based upon six different age conceptualizations differentially impact workplace motivation. In the first known study to examine all conceptualizations of age simultaneously, results suggested the age conceptualizations of subjective age and health significantly impact growth motives for older workers, but not social or security motives. Results suggest social motives are influenced more by chronological age as opposed to other conceptualizations of age. Implications for practitioners in designing and implementing HR activities (e.g., succession planning) and researchers in utilizing all the conceptualizations of age and studying workplace interventions are discussed.
The Impact Of Folate Restriction On Cancer And Aging: A Mechanistic Analysis, Safa Beydoun
The Impact Of Folate Restriction On Cancer And Aging: A Mechanistic Analysis, Safa Beydoun
Wayne State University Dissertations
Aging is a multifactorial process associated with alterations in several physiological functions. It increases susceptibility to disease and ultimately results in mortality. Since the associated diseases of aging are highly prevalent in the geriatric population, targeting the aging process as a whole may provide a better way to delay these age related diseases, in turn delaying aging. Various interventions have been shown to delay aging and age related diseases. They impact a major nutrient sensing pathway, mTOR. mTOR signaling is altered in many cancers and its downregulation was shown to delay aging. Other interventions extend lifespan by altering the one …