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Imaging The Vasculature With Susceptibility Weighted Imaging: Applications And Analysis, Samuel Barnes
Imaging The Vasculature With Susceptibility Weighted Imaging: Applications And Analysis, Samuel Barnes
Wayne State University Dissertations
Modern magnetic resonance imaging sequences allow detailed non-invasive imaging of both the arteries and veins. This work is divided into four sections that examine different applications and analysis of these sequences.
Susceptibility weighted imaging (SWI) typically generates excellent negative venous contrast. Techniques to generate positive arterial contrast in SWI images without degrading the venous contrast with a single echo are examined. By using high isotropic resolution and high readout bandwidth flow losses can be minimized (generating good arterial contrast) even at the long echo times required for good venous contrast. A downsampling filter is then used to restore lost venous …
Quantification Of Vascular Parametric Indices Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Areen Khaled Al.Bashir
Quantification Of Vascular Parametric Indices Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Areen Khaled Al.Bashir
Wayne State University Dissertations
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a non-invasive method used to evaluate the biological activity in early clinical trials of novel drugs targeting the tumor vasculature using gadolinium-DTPA (Gd) as a contrast agent. However, it has some limitations, such as reproducibility, data acquisition times, the presence of noise, extracting contrast concentration, estimating T1 relaxation and estimating pharmacokinetic parameters.
In this work, a new approach to used fixed T1(0) which provides more reproducible DCE results has been introduced. Using this new algorithm to quantify the vascular changes in DCE-MRI, a pre-clinical renal cell carcinoma (RCC) tumor model was used to …