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Isothermal Titration Calorimetry Studies Of Protein-Mediated Interactions And Preliminary Structural Studies Of Tandem Pdz1-2 Domain Of Psd-95 Protein, Ana Jankovic
Wayne State University Dissertations
Protein-mediated interactions that involve multiple ligands in their binding mechanisms are critical for many cellular functions. The primary focus of this dissertation research was to investigate such interactions for two proteins, the PDZ domain and frataxin, involving peptide and metal binding ligands, respectively. The three component projects of this work comprised (1) thermodynamic analysis of PDZ domain binding using calorimetry; (2) X-ray crystallographic structural studies of a PDZ dual domain; and (3) thermodynamic analysis of frataxin binding to iron. The specific goal of the research conducted with the PDZ domains was to understand the mechanism of action of multiple/tandem protein …
Does A Sense Of Control Moderate Self-Regulation Strategies And Performance? When Feedback Lingers, Annette Feravich
Does A Sense Of Control Moderate Self-Regulation Strategies And Performance? When Feedback Lingers, Annette Feravich
Wayne State University Dissertations
ABSTRACT
This study examined whether a sense of control moderated the relationship between self-regulation and performance on an anagram task. High school students agreeing to participate in this study completed the Behavioral Inhibition/Behavioral Approach Scale (BIS/BAS) in order to determine individual promotion or prevention chronic self-regulatory strategies, as well as the revised Children's Attributional Style Questionnaire (CASQ-R) to determine a sense of control based on explanatory style. Changes in mood and performance on anagram tasks were measured at three different times during the study: prior to, after, and after discrediting randomly assigned negative or positive feedback. Performance tasks were designed …
Patient Safety As An Interactional Achievement: Conversational Analysis In The Trauma Center Of An Inner City Hospital, Margaret Karadjoff
Patient Safety As An Interactional Achievement: Conversational Analysis In The Trauma Center Of An Inner City Hospital, Margaret Karadjoff
Wayne State University Dissertations
In this dissertation, I apply the methodology of Conversational Analysis to highlight the informal communication of an emergency room work group with the objective of discovering recurrent patterns of interaction and the inherent relational work necessary to accomplish the safe medical care of patients in a Trauma Code on a level of safety comparative to that of ultra-safe systems as described in the literature of High Reliability Organizations.
The significance of relational elements of interaction on emerging social order is highlighted in processes of attunement, or the diminishing of difference of status in the use of mitigated speech and the …