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Articles 1 - 5 of 5
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The Importance Of Protein Context In Spinocerebellar Ataxia Type 3, Sean Luis Johnson
The Importance Of Protein Context In Spinocerebellar Ataxia Type 3, Sean Luis Johnson
Wayne State University Dissertations
Spinocerebellar Ataxia Type 3 (SCA3) is a member of the family of polyglutamine (polyQ) neurodegenerative disorders that includes Huntington's Disease and several other SCAs. SCA3, the most common dominant ataxia in the world, is caused by polyQ tract expansion in the protein, ataxin-3. How SCA3 occurs and how to treat it remain unresolved issues. The primary culprit of toxicity in all polyQ diseases is the glutamine repeat: its abnormal expansion leads to neuronal dysfunction and death. With that said, there is indisputable evidence that the way polyQ-dependent toxicity presents—areas impacted, cellular processes perturbed—is predicated in large part on regions outside …
Novel Interaction Of Cxcr4 And Pi4kiiiα In Prostate Cancer, Barani Govindarajan
Novel Interaction Of Cxcr4 And Pi4kiiiα In Prostate Cancer, Barani Govindarajan
Wayne State University Dissertations
The CXCR4-CXCL12 chemokine signaling axis plays a key role in migration and bone metastasis in prostate cancer (PC). Androgens regulate CXCR4 expression and its receptor activation in lipid-raft micro domains of PC cells, resulting in higher protease expression and invasion. In order to identify some novel CXCR4 co-regulators associated within the lipid-raft, a SILAC (Stable isotope labeling using amino acid in cell culture)-based proteomic analysis was performed with PC3 stable cell-lines over-expressing or knocking-down CXCR4. Phosphatidylinositol 4-kinase III alpha (PI4KIIIα or PI4KA) and SAC1 lipid phosphatase were identified as candidate proteins enriched in CXCR4 expressing cells. PI4KA is an evolutionarily …
Backward Walking: A Novel Marker Of Fall Risk, Cognitive Dysfunction, And Myelin Damage In Persons With Multiple Sclerosis, Erin Edwards
Backward Walking: A Novel Marker Of Fall Risk, Cognitive Dysfunction, And Myelin Damage In Persons With Multiple Sclerosis, Erin Edwards
Wayne State University Dissertations
Multiple sclerosis (MS) is a progressive, neurologic disease of the central nervous system that causes debilitating motor, sensory and cognitive impairments. As a result, persons with MS are at an increased risk for falls and falls represent a serious public health concern for the MS population. The current clinical measures used to assess fall risk in MS patients lack sensitivity and predictive validity for falls and are limited in their ability to capture to multiple functional domains (i.e., motor, sensory, cognitive and pathological domains) that are impaired by MS. Backward walking sensitively detects falls in the elderly and other neurologic …
Hearing And Other Factors Influencing Memory Performance In Remote Assessment, Erika Squires
Hearing And Other Factors Influencing Memory Performance In Remote Assessment, Erika Squires
Wayne State University Dissertations
With the revitalization of aural rehabilitation (AR) and increased use of telepractice services, there is a paucity of research examining factors that have the potential to affect remote assessment. An assessment of memory is commonly included in a comprehensive AR assessment because recently developed auditory-cognitive training programs include auditory-based cognitive activities, such as auditory memory tasks. This investigation explored the effect of presentation modality on speech discrimination performance and whether self-reported hearing ability correlated with remote memory assessment in older adults.Older adults self-reported their hearing abilities and completed speech discrimination and memory tasks. Data were collected remotely via a telephone …
The Lived Experiences Of Muslim Women With Infertility, Samia Abdelnabi
The Lived Experiences Of Muslim Women With Infertility, Samia Abdelnabi
Wayne State University Dissertations
Background: Infertility, ranked as the 5th highest global disability, is estimated to impact 180 million couples worldwide. Muslim couples associate parenthood or the ability to have children as an accomplishment in their marriage, adulthood, social status, and security in later life. A failure to conceive in Muslim societies may lead to stigma, social isolation, grief, and despair. There is a gap in the literature on how Muslim women perceive, understand, and cope with infertility in the U.S. This knowledge gap limits the ability in to understand how social, religious, and cultural practices impact a diagnosis of infertility on Muslim American …