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Articles 1 - 6 of 6
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Activation Of Tumor Cell Death Program By Targeting The Ubiquitin-Proteasome Pathway: Significance In Cancer Treatment And Prevention, Michael Joseph Frezza
Activation Of Tumor Cell Death Program By Targeting The Ubiquitin-Proteasome Pathway: Significance In Cancer Treatment And Prevention, Michael Joseph Frezza
Wayne State University Dissertations
ACTIVATION OF TUMOR CELL DEATH PROGRAM BY TARGETING THE UBIQUITIN-PROTEASOME PATHWAY: SIGNIFICANCE IN CANCER TREATMENT AND PREVENTION
by
MICHAEL FREZZA
August 2010
Advisor: Dr. Q. Ping Dou
Major: Cancer Biology
Degree: Doctor of Philosophy
The ubiquitin-proteasome pathway serves as a quality control mechanism to regulate the degradation of intracellular proteins involved in a wide array of cellular processes including tumorigeneis. Thus targeting key features of protein turnover responsible for the growth and proliferation of cancer have emerged as a favorable approach in cancer therapy. Both in vitro and in vivo experimental and clinical results have demonstrated the potential use of …
Synergistic Effects Of Garcinol And Gemcitabine In Enhancing Therapeutic Efficacy In Pancreatic Adenocarcinoma Cells And Its Effect On Microrna Profile, Mansi Anand Parasramka
Synergistic Effects Of Garcinol And Gemcitabine In Enhancing Therapeutic Efficacy In Pancreatic Adenocarcinoma Cells And Its Effect On Microrna Profile, Mansi Anand Parasramka
Wayne State University Dissertations
SYNERGISTIC EFFECTS OF GARCINOL AND GEMCITABINE IN ENHANCING THERAPEUTIC EFFICACY IN PANCREATIC ADENOCARCINOMA CELLS AND ITS EFFECT ON MICRORNA PROFILE
By
MANSI PARASRAMKA
ADVISOR: DR. SMITI V. GUPTA
MAJOR: NUTRITION AND FOOD SCIENCE
DEGREE: DOCTOR OF PHILOSPHY
Human Pancreatic Cancer (PaCa) is one of the most hostile and fourth leading cause of cancer deaths in the United States. Current standard chemotherapeutic agent for advanced PaCa is gemcitabine, a cytotoxic nucleoside analogue which results in modest response due to high degree of inherent and acquired chemo resistance. Forthcoming evidence strongly supports that non-nutritive food components have therapeutic benefits attributable to pleiotropic …
Defensins In Ocular Immunity, Minhao Wu
Defensins In Ocular Immunity, Minhao Wu
Wayne State University Dissertations
Corneal infection with P. aeruginosa results in corneal perforation in susceptible
B6, but not resistant BALB/c mice. This study explored their role mBD 1-4 in corneal
infection, and their potential synergy. Immunostaining and real-time RT-PCR data
demonstrated that their expression was either constitutive (mBD1 and mBD2) or
inducible (mBD3 and mBD4) in normal BALB/c and B6 corneas, and disparately
regulated in BALB/c vs B6 corneas after infection. Knock down studies using siRNA
treatment indicated that mBD2 and mBD3, but neither mBD1 nor mBD4, is required in
ocular defense. Moreover, in vivo studies demonstrated individual and combined effects
of mBD2 and …
Identification Of Neuroblastoma And Its Prognostic Markers Using Raman Spectroscopy, Rachel Kast
Identification Of Neuroblastoma And Its Prognostic Markers Using Raman Spectroscopy, Rachel Kast
Wayne State University Dissertations
Introduction: Neuroblastoma is the most common cancer of infancy. It is one of several peripheral nervous system tumors, including ganglioneuroma, peripheral nerve sheath tumor, and pheochromocytoma. It is commonly situated on the adrenal gland. It displays similar histology to other small round blue cell tumors, including non-Hodgkin lymphoma, rhabdomyosarcoma, and Ewing sarcoma. One method of judging neuroblastoma aggressiveness uses tumor histology factors, including mitosis-karyorrhexis index, Schwannian stromal development, degree of differentiation, and patient age. Tumor aggressiveness can also be judged based on the amplification of certain genes, including MYCN. Raman spectroscopy is a physics-based method which identifies the biochemical …
Application Of Magnetic Resonance Imaging To Understanding The Pathogenesis Of The X-Linked Leukodystrophy Pelizaeus-Merzbacher Disease, Jeremy Jerome Laukka
Application Of Magnetic Resonance Imaging To Understanding The Pathogenesis Of The X-Linked Leukodystrophy Pelizaeus-Merzbacher Disease, Jeremy Jerome Laukka
Wayne State University Dissertations
Myelin is a multilamellar membrane structure surrounding axons in both the CNS and PNS that facilitates nerve conduction. In the CNS, myelin is synthesized by oligodendrocytes, while in the PNS, myelin is synthesized by Schwann cells. In the CNS, Proteolipid protein 1 (PLP1), an integral membrane protein, is the major protein component of myelin, constituting ~50% of myelin protein. Mutations of the PLP1 gene in man cause a spectrum of neurological disease, ranging from the severe Pelizaeus-Merzbacher disease (PMD), that typically begins during infancy with nystagmus, seizures and hypotonia and evolves into spastic quadriparesis, cognitive impairment and ataxia, to ¡¥pure¡¦ …
Adaptive Radiation Therapy Of Prostate Cancer, Ning Wen
Adaptive Radiation Therapy Of Prostate Cancer, Ning Wen
Wayne State University Dissertations
ART is a close-loop feedback algorithm which evaluates the organ deformation and motion right before the treatment and takes into account dose delivery variation daily to compensate for the difference between planned and delivered dose. It also has potential to allow further dose escalation and margin reduction to improve the clinical outcome. This retrospective study evaluated ART for prostate cancer treatment and radiobiological consequences. An IRB approved protocol has been used to evaluate actual dose delivery of patients with prostate cancer undergoing treatment with daily CBCT.
The dose from CBCT was measured in phantom using TLD and ion chamber techniques …