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The Role Of Orphan Nuclear Receptor Dax-1 (Nr0b1) In Human Breast Cancer Cells: Expression, Proliferation And Metastasis, Erin Dishington
The Role Of Orphan Nuclear Receptor Dax-1 (Nr0b1) In Human Breast Cancer Cells: Expression, Proliferation And Metastasis, Erin Dishington
Master's Theses
The orphan nuclear hormone receptor DAX-1 (Dosage Sensitive Sex Reversal, Adrenal Hypoplasia Congenita on the X Chromosome, gene 1) plays an important role in the development of adrenal and gonadal tissues and functions as a global negative-regulator of steroidogenesis. In addition, it is known to be involved in several diseases including some cancers. Herein, we describe our examination of the role of DAX-1 in breast cancer, specifically its influence on proliferation and metastasis and its expression during progressive stages of disease. In an effort to understand how DAX-1 influences breast cancer cell proliferation and metastasis, we used MCF7 breast cancer …
Regulation Of Proliferation, Apoptosis, And Metastasis In Prostate Cancer Cells By Dax-1 (Nr0b1)- An Androgen-Induced Orphan Nuclear Receptor, Roxxana Valeria Beltran Valencia
Regulation Of Proliferation, Apoptosis, And Metastasis In Prostate Cancer Cells By Dax-1 (Nr0b1)- An Androgen-Induced Orphan Nuclear Receptor, Roxxana Valeria Beltran Valencia
Master's Theses
DAX-1 (Dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X-chromosome, gene 1) is an unusual member of the Nuclear Hormone Receptor superfamily that has the ability to interact with other Nuclear Receptors (NRs) and transcriptional co-repressors and co-activators. While DAX-1 plays an important role in adrenal and gonadal development, recent studies have elucidated the role DAX-1 plays as a transcriptional repressor and its influence on the progression of different types of cancers. The primary aim of this thesis research project is to investigate the role of non-aromatizable androgens in inducing DAX-1 expression and to determine how DAX-1 influences …
Transcriptional Regulation By Dax-1 In Pluripotent And Differentiated Cells, Alexandra C. Maramba
Transcriptional Regulation By Dax-1 In Pluripotent And Differentiated Cells, Alexandra C. Maramba
Master's Theses
DAX-1, an orphan nuclear hormone receptor, acts mainly as a repressor through transcriptional protein complexes. Its unique structure and specific expression raises questions as to what its precise interactions are and how it mediates its repressive function. While it is known to play a role in sexual development and adrenal insufficiency, expression in certain types of cancer suggests additional functions and interactions. Knock in of DAX-1 into a low-DAX-1 expressing cancer cell line has been previously observed to increase apoptosis, while, inversely, down in a high-DAX-1 expressing cancer cell line shows a decrease in apoptosis. Target genes that belong to …
Epigenetic Regulation Of Nuclear Hormone Receptor Dax-1, Michael B. Heskett
Epigenetic Regulation Of Nuclear Hormone Receptor Dax-1, Michael B. Heskett
Master's Theses
DAX-1 (NR0B1) is an orphan nuclear receptor that plays a key role in the development and maintenance of steroidogenic tissue in mammals. Dax-1 is also expressed in mouse embryonic stem (ES) cells and is required to maintain pluripotency. Duplication of the X-chromosome in the region containing the NR0B1 gene results in sex reversal, and mutations in NR0B1 cause adrenal hypoplasia congenita. DAX-1 has been observed to act as a corepressor of other nuclear receptors including androgen receptor (AR), estrogen receptor (ER), and steroidogenic factor 1 (SF-1). In addition to pluripotent ES cells, DAX-1 is primarily expressed in select tissues of …
Examining The Role Of Dax-1 In Regulation Of Cell Proliferation In Human Breast Cells, Amy E. Scandurra
Examining The Role Of Dax-1 In Regulation Of Cell Proliferation In Human Breast Cells, Amy E. Scandurra
Master's Theses
DAX-1 is a member of the Nuclear Hormone Receptor superfamily and acts as a transcriptional repressor. DAX-1 plays an important role in the development of adrenal and gonadal tissues. In addition to its role in normal cell development and differentiation, DAX-1 appears to have some influence on the progression of cancer. This work aims to examine the role of DAX-1 in regulation of proliferation in breast cancer. In our study, we have expressed DAX-1 in a DAX-1 deficient breast cancer cell line as well as knocked down DAX-1 expression in normal DAX-1 positive breast cells. Through these experiments, we were …