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A Quantitative Histological Evaluation Of Articular Cartilage And Regenerated Tissue From A Stress-Shielded In Vivo Model, Jeremy Matthew Kupsco
A Quantitative Histological Evaluation Of Articular Cartilage And Regenerated Tissue From A Stress-Shielded In Vivo Model, Jeremy Matthew Kupsco
Master's Theses
Cartilage does not normally repair lesions. Cartilage induced to regenerate experimentally degenerates quickly, perhaps because stresses of articulation do not allow normal extracellular matrix to develop. I examined normal cartilage from dogs, pigs, rabbits, and humans, and canine patellar tissue regenerated in a stress-shielded environment. SEM of canine cartilage after trypsin digestion revealed meshworks of fibrils oriented with a bias normal to the surface in the deep zone, random in the middle zone, and parallel to the surface in the superficial zone. SEM after freeze-fracture revealed tubules of fibrils within the deep zone. I found no evidence of collagen arcades. …
Storm-Related Suspended Particulate Matter In Little Westham Creek, John R. Jordan
Storm-Related Suspended Particulate Matter In Little Westham Creek, John R. Jordan
Master's Theses
Properties of a watershed regulate the amount of suspended particulate matter (SPM) in a stream. The present study examined relationships between storm-related SPM and impervious area and tree cover in the suburban watershed of Little Westham Creek, Richmond, Virginia during Summer and early Fall, 1999. SPM concentration, SPM discharge, and turbidity due to clay, silt and sand, and the areas of impervious surface and tree stand cover in the watershed were measured at three sites. SPM concentration, SPM discharge, and turbidity due to clay were greater upstream than downstream. The percentages of watershed area covered by impervious surfaces and tree …
The Role Of Matrix Metalloproteinase-2 In Glioma Invasion, Nicole Danielle Sauers
The Role Of Matrix Metalloproteinase-2 In Glioma Invasion, Nicole Danielle Sauers
Master's Theses
Overexpression of matrix metalloproteinase 2, MMP-2, is correlated with highgrade gliomas in vivo. The purpose of this study was to investigate whether MMP-2 overexpression in glioma cell lines leads to increased invasion of glioma cells in vitro. The entire MMP-2 gene was isolated from U87, a glioma cell line known to have high expression of wild-type MMP-2. This :tvIMP-2 gene was inserted in a sense and antisense orientation into pCR3 .1 vectors with a CMV promoter to ensure high levels of expression. Glioma cell lines were transfected with the sense and antisense constructs, as well as the pCR3.l vector alone …