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Quantitative Trait Loci Influencing Elemental Content In Grapevine Leaves, Jesse L. Krokower Jan 2024

Quantitative Trait Loci Influencing Elemental Content In Grapevine Leaves, Jesse L. Krokower

MSU Graduate Theses

In grapevine, the influence of the plant’s elemental composition (the ionome) on fruit and wine quality is well established, but its genetic underpinnings have received limited scientific attention. In this study, I analyzed the leaf ionome of 131 interspecific F1 hybrid progeny plants from a cross between a Vitis rupestris Scheele (♀) and a Vitis riparia Michx (♂) parents, which were replicated in four different environments: Southwest Missouri, Central Missouri, South Dakota, and New York. I sampled leaves at three different times during the growing season at all four locations and had the concentration of 20 elements measured using ICP-MS. …


Crisis Communication And Public Relations: How Fairs Communicated Cancellations During The Covid-19 Pandemic, Olivia Mckenna Robinson Jan 2023

Crisis Communication And Public Relations: How Fairs Communicated Cancellations During The Covid-19 Pandemic, Olivia Mckenna Robinson

MSU Graduate Theses

The COVID-19 pandemic halted aspects of a traditional fair including the agriculture, home economics, entertainment, and carnival exhibits that were missed by the diverse stakeholders who enjoy the traditions of this industry. This study examined how fairgoers reacted to the news of cancellation and investigated fair managers’ communication decisions. An explanatory sequential (QUANT → QUAL) mixed methods design was used. A survey was conducted asking fairgoers to recall communication strategies and feelings after the communication. A more in-depth focus group with fair managers was hosted to understand how crisis communication was utilized, and if active information seekers versus passive information …


Body Condition: Seasonal Effects And Influence On Aggressive Behavior Of Ozark Zigzag Salamanders (Plethodon Angusticlavius), Ayesha Farooq Jan 2023

Body Condition: Seasonal Effects And Influence On Aggressive Behavior Of Ozark Zigzag Salamanders (Plethodon Angusticlavius), Ayesha Farooq

MSU Graduate Theses

Body condition is a measure of the size of energy reserves such as fat and protein, which can influence health and the ability to obtain resources in aggressive encounters. Individuals with better body condition ultimately experience a fitness advantage. Physiological factors such as sex, reproductive condition, and diet can influence body condition of individuals. Body condition could be affected positively or negatively after an animal is kept in captivity for extended periods of time. In the first chapter, I explore whether sex, season (fall and spring), and time in containment at the laboratory influences body condition. In the second chapter, …


Centrifugation Cushion Vs. Spermfilter™: Effects On % Recovery, Holly S. Hopkins Jan 2023

Centrifugation Cushion Vs. Spermfilter™: Effects On % Recovery, Holly S. Hopkins

MSU Graduate Theses

It has been demonstrated that removing seminal plasma and resuspension of the sperm pellet in various diluents will improve the post-storage motility of spermatozoa from some stallions. This typically involves centrifugation. However, a sperm filtering device marketed by Botupharma (Phoenix, AZ) allows seminal plasma removal without a centrifuge. This study compared spermatozoa recovery rates using this device vs. centrifugation with and without a cushion. Thirteen ejaculates were collected from three quarter horse stallions. Prior to treatment, aliquots were diluted with Dulbecco's modified PBS at a dilution rate of 1:1. For the two centrifugation treatments, 12 ml of the diluted semen …


Distribution Patterns Of Allorhizobium Vitis In Missouri Vineyards And Non-Vineyard Soils, Jacquelyn M. Wray Jan 2023

Distribution Patterns Of Allorhizobium Vitis In Missouri Vineyards And Non-Vineyard Soils, Jacquelyn M. Wray

MSU Graduate Theses

Crown gall disease causes significant economic loss to the grape and wine industry. Preventive strategies are most effective for mitigating the loss of grapevines in vineyards, as there is no known cure for this disease. The bacterium Allorhizobium vitis carrying a tumor-inducing (Ti) plasmid is the causative agent. A. vitis bacteria live systemically in the grapevine before causing visible symptoms and can survive in residual plant tissues and soil for more than two years. Diagnostic methods have been developed to detect A. vitis bacteria in grapevines and soil. However, more reliable, specific, and high-throughput diagnostics are still needed for screening …


Between Choice And Compulsion: An Examination And Critique Of The Evolution Of 'Original Sin', Matthew James Wynn Jan 2023

Between Choice And Compulsion: An Examination And Critique Of The Evolution Of 'Original Sin', Matthew James Wynn

MSU Graduate Theses

“Why are we the way that we are?” is one of the hardest questions to answer because it requires grasping the origin of human beings. This has left philosophers and theologians in century-long debates on forming a “cosmogony of ontology” (i.e., how the origin of the universe informs the human condition). The concept, “original sin” was developed by a North African theologian named Augustine (354 – 430 CE). Augustine’s reading of Genesis 3, and inaccurate translation of Romans 5:12, taught that a person is born morally culpable for a fault antecedent to their existence. This way of thinking about the …


Impact Of Sample Conditions On Dna Phosphodiester Backbone Bi/Bii Conformational Equilibrium Dynamics, Autumn C. Pilarski Jan 2023

Impact Of Sample Conditions On Dna Phosphodiester Backbone Bi/Bii Conformational Equilibrium Dynamics, Autumn C. Pilarski

MSU Graduate Theses

DNA damage, such as single base lesions and mismatches, is highly prevalent within cells. If these DNA damage events are not repaired, they could lead to mutations and thus disease and cancer. Intricate repair mechanisms are in place to fix these damage events, one such being Base Excision Repair (BER) and associated enzyme: Thymine DNA Glycosylase (TDG). The first step of this repair process, recognition of the lesion by TDG, is not well understood. The following thesis presents results to better understand the fundamental biophysical question of how a DNA lesion within a mismatch context is recognized in a million …


Investigation To Examine The Profile Of Auditory Brainstem And Hearing Thresholds Using Tone Burst Audiometry Brainstem Response In A Preclinical Migraine Model, Megan Huelsing Jan 2023

Investigation To Examine The Profile Of Auditory Brainstem And Hearing Thresholds Using Tone Burst Audiometry Brainstem Response In A Preclinical Migraine Model, Megan Huelsing

MSU Graduate Theses

Migraine is a disabling neurological disease that is characterized by prominent auditory symptoms, including hyperacusis, which is defined as extreme sensitivity to sounds. The goal of this study was to investigate changes in hearing sensitivity and neural changes in the brainstem by measuring neural activity of the auditory brainstem in an established preclinical model of chronic migraine. To induce a chronic migraine state within the trigeminal system, male and female Sprague Dawley rats were subjected to three known human risk factors including neck muscle tension and REM sleep deprivation that promote latent sensitization, and exposure to a pungent odor, which …


Examining The Immune Regulation Of Nlrp12 Through Novel Protein Interactions, Catherine Rippe Jan 2023

Examining The Immune Regulation Of Nlrp12 Through Novel Protein Interactions, Catherine Rippe

MSU Graduate Theses

NOD-like receptors (NLRs) are intracellular proteins that play an important role in the regulation of the innate immune response to pathogens. Since being identified, various functions for NOD-like receptor pyrin domain containing 12 (NLRP12) have been suggested. It has been shown to negatively regulate the inflammatory response through canonical and noncanonical NF-kB signaling pathways, control tumorigenesis and gut homeostasis and exacerbate inflammation through the formation of a multi-protein complex called an inflammasome. Due to the varying roles established for NLRP12, the mechanisms by which it functions remain poorly understood. In this study, I sought to confirm a novel protein-protein interaction …


Modeling Growth And Stress Factors For Converted Silvopasture Systems In The Missouri Ozarks, Bailee N. Suedmeyer Jan 2023

Modeling Growth And Stress Factors For Converted Silvopasture Systems In The Missouri Ozarks, Bailee N. Suedmeyer

MSU Graduate Theses

Silvopasture systems are becoming increasingly popular among sustainable agriculture ranchers, due to the increase in knowledge of benefits to the cattle and ability to grow cool season grasses beneath the canopy. This project focuses on the forest crop aspect of silvopasture systems from monitoring of the health of the trees over time to recommendations for thinning management to keep it functioning as viable silvopasture. The study site consists of five acres of upland hardwood forest area in Southern Missouri with 18 monumented fixed area plots. Arial and ground data was collected at each plot throughout the growing season, along with …


Quantitative Song Variety In Relation To Genotype In A Hybridizing Chickadee Population, Shelby Madison Palmer Jan 2023

Quantitative Song Variety In Relation To Genotype In A Hybridizing Chickadee Population, Shelby Madison Palmer

MSU Graduate Theses

The Black-capped chickadee (Poecile atricapillus) and Carolina chickadee (P. carolinensis) are North American songbird species that hybridize in a narrow contact zone stretching latitudinally from New Jersey to Kansas, USA. The association between genetic ancestry and song type in this hybrid zone has been studied independently several times and found to be minimal or absent, likely due to the influence of cultural transmission on learned song in the oscine passerine clade to which the chickadees belong. Despite this, the song of both species remains remarkably distinct in allopatry, suggesting a genetic constraint on certain qualities of …


Morphological And Genetic Analysis Of The Root System In Two American Grapevines (Vitis Species), Parinaz Mohtasebi Jan 2023

Morphological And Genetic Analysis Of The Root System In Two American Grapevines (Vitis Species), Parinaz Mohtasebi

MSU Graduate Theses

The North American grapes species Vitis rupestris Scheele and Vitis riparia Michx have been the pillars of rootstock breeding for many decades. Though a large body of viticultural knowledge has been accumulated on their impact on grafted scions, the genetic basis of their root system architecture (RSA) has received limited scientific attention. In this study, I generated and analyzed adventitious root systems from dormant cuttings of 22 V. riparia and 19 V. rupestris accessions, as well as 162 interspecific F1 hybrid progeny from a cross between V. rupestris (♀) and V. riparia (♂). I photographed the roots and then extracted …


Influence Of Cell Cycle On Aim2 Inflammasome Activation, Ashok Kumar Dubey Jan 2023

Influence Of Cell Cycle On Aim2 Inflammasome Activation, Ashok Kumar Dubey

MSU Graduate Theses

A cell cycle's progression has a significant role in the development of a disease. All the signaling pathways and inflammatory reactions are maintained in a healthy mode if cell cycle checkpoints are precisely regulated and kept in homeostasis. AIM2 inflammasome is a cytoplasmic double-stranded DNA sensor. Upon activation, it elicits an inflammatory reaction with the release of pro-inflammatory cytokines such as IL-1β and IL-18 and they are cleaved by the proteases, Caspase-1 from their inactive form. Also, the AIM2 inflammasome helps in regulating cell division and inhibits cell proliferation; thus, leading to a cell death called pyroptosis. Here, I examined …


Investigation Of Inflammation And Apoptosis Mediated Toxicity In Response To Metal Oxide Nanoparticles In Ml-1 And Ca77 Cancer Cell Lines, Alyse N. Peters Jan 2023

Investigation Of Inflammation And Apoptosis Mediated Toxicity In Response To Metal Oxide Nanoparticles In Ml-1 And Ca77 Cancer Cell Lines, Alyse N. Peters

MSU Graduate Theses

Metal oxide nanoparticles (MONPs) are becoming more popular in today’s environment. They contribute significantly to the technologies in agriculture and food development but there is little understanding to how MONPs, including ZnO, CuO, TiO2, and SnO2, impact human health and the environment. Our growth assay revealed that none of these negatively affects viability in the budding yeast, Saccharomyces cerevisiae. In contrast, both human thyroid cancer cells (ML-1) and rat medullary thyroid cancer cells (CA77) displayed a significant reduction in viability with the treatment of CuO and ZnO. The production of ROS in these cell lines when treated with CuO and …


A Comparison Of Peak Ground Reaction Forces Of Pitches From The Stretch And Windup, Richard D. Edwards Jan 2023

A Comparison Of Peak Ground Reaction Forces Of Pitches From The Stretch And Windup, Richard D. Edwards

MSU Graduate Theses

Ground reaction forces can help coaches and players understand the lower extremity biomechanics of pitching in baseball. Research has told us that there are repeatable characteristics of ground reaction forces that pitchers produce during a pitch. This study examines the differences in peak ground reaction forces produced from pitching from the stretch versus pitching from the wind-up. Five variables were recorded for each pitch from the push-off leg and the landing leg. Landing forces were then compared to landing forces of the other pitching style and the same comparison was made for the push-off leg. This was achieved by altering …


Propagation, Physiology And Biomass Of Giant Cane (Arundinaria Gigantea) For Conservation And Restoration, Sanjeev Sharm Jan 2023

Propagation, Physiology And Biomass Of Giant Cane (Arundinaria Gigantea) For Conservation And Restoration, Sanjeev Sharm

MSU Graduate Theses

Giant cane (Arundinaria gigantea) is a native species to 22 states in the U.S. The species and its ecosystem are considered critically endangered, and the species has been reduced to 2% of its original extent. The species has a long cultural and conservation history. Large canebrakes were commonly found in Missouri in bottomland forests, stream and riverbanks, and margins of lakes. My research goals were to: 1) examine methods for propagation success from field to greenhouse to field; 2) examine the physiology of cane at one of the few current canebrakes, for greenhouse propagated plants, and field planted …


Intraspecific Hybrid Identification Of Black Walnuts Via Marker Assisted Selection, Makenna B. Thompson Jan 2023

Intraspecific Hybrid Identification Of Black Walnuts Via Marker Assisted Selection, Makenna B. Thompson

MSU Graduate Theses

The improvement of Eastern black walnut (Juglans nigra L.) cultivars could increase market expansion. Improved cultivars with superior qualities would increase profitability for both the seller and the buyer. Agronomically and economically important traits such as heavier nut weight, disease resistance, tree structure integrity, and yearly nut production can be efficiently improved by breeding black walnuts via marker-assisted selection. Microsatellite/simple sequence repeat markers were used in this research to determine potential intraspecific hybrids between ‘Football’ and ‘Sparrow’ cultivars. Intraspecific is defined as of the same genus and species. This quality makes it more difficult to identify hybrids because the parent …


Natural Transmission Of Grapevine Vein Clearing Virus, Matthew Manu Jan 2023

Natural Transmission Of Grapevine Vein Clearing Virus, Matthew Manu

MSU Graduate Theses

More than 60 million tons of grapes are produced annually in the world, making them one of the most widely grown fruit crops. Despite grapes’ economic and health benefits, biotic stressors, such as viruses, cause significant loss to the grape and wine industry. One such virus is grapevine vein clearing virus (GVCV) which seriously threatens grape cultivation in the Midwest region of the United States. This virus has caused the removal of seven commercial vineyards since its discovery in 2004. About 34% of Ampelopsis cordata wild vines are infected with GVCV and serve as a primary inoculum for the spread …


Tissue And Sex-Dependent Regulation Of Innate Immunity And Rna Editing In Mice, Kelsey R. Kendrick Jan 2023

Tissue And Sex-Dependent Regulation Of Innate Immunity And Rna Editing In Mice, Kelsey R. Kendrick

MSU Graduate Theses

Inflammation occurs as a result of insult or infection within the body. Individual cells respond to inflammation by upregulating genes that help mediate the immune response, such as ADAR1. ADAR1 helps regulate the immune response but also catalyzes a process called RNA editing. RNA editing alters the sequence of select mRNAs to alter the encoded proteins. The result is altered function of the encoded protein, which is often beneficial for the cell. Our goal was to determine how inflammation affects the function of ADAR1. Since we know that the effects of inflammation vary between different organs and sexes, we examined …


Sex-Dependent Effects Of Induced Acute Inflammation On Glucose Homeostasis And Rna Editing Enzymes, Christian A. Rivas Jan 2023

Sex-Dependent Effects Of Induced Acute Inflammation On Glucose Homeostasis And Rna Editing Enzymes, Christian A. Rivas

MSU Graduate Theses

The first line of defense against bodily insults, like pathogen invasion, is the innate immune system. Innate immunity sets in motion countless cascades that result in inflammation. Inflammation simultaneously affects multiple biological processes like metabolism and gene expression. Males and females react differently to inflammation. To understand both molecular and physiological sex differences in inflammation, we examined how inflammation affects gene expression and glucose metabolism. Adenosine deaminase acting on RNA (ADAR1) is upregulated by inflammation and catalyzes RNA editing, a process where nucleotides encoded by the genome are modified. ADAR1 also controls the innate immune reaction by decreasing activity of …


Phenomenological Study Into The Role Of Self-Efficacy In Minority Student-Athletes' Sport Performance, Tomas A. Singhgolden Jan 2023

Phenomenological Study Into The Role Of Self-Efficacy In Minority Student-Athletes' Sport Performance, Tomas A. Singhgolden

MSU Graduate Theses

Self-efficacy is a person’s belief in their ability to successfully complete a task, which can be derived from four sources of information (i.e., past performance, vicarious experience, verbal persuasion, and physiological states). The role of self-efficacy in sporting performance is well documented as being positively associated with enhanced performance across multiple levels of sport (e.g., Olympic, collegiate athletes). Specifically, with collegiate athletes, high levels of reported self-efficacy have resulted in higher performance accomplishments. Although self-efficacy has been researched within sports, there is a dearth of knowledge examining ethnic minority athletes’ perceptions of self-efficacy related to their athletic performance. The aim …


Cul3 Negatively Regulates Nlrp12-Mediated Inhibition Of The Canonical Nf-Κb Signaling Pathway, Inyeong Lee Jan 2023

Cul3 Negatively Regulates Nlrp12-Mediated Inhibition Of The Canonical Nf-Κb Signaling Pathway, Inyeong Lee

MSU Graduate Theses

Nod-like receptor family pyrin domain-containing protein 12 (NLRP12) is mainly known for its inhibitory function on NF-κB signaling in innate immune cells, and more recently, for its ability to regulate chemokine signaling and ubiquitination of the immune receptor RIG-I. Through a yeast 2-hybrid screen, the Lupfer lab previously discovered that NLRP12 interacts with other ubiquitin-associated proteins including Cullin 3 (CUL3) and RING finger protein 2 (RNF2). This research was conducted to mainly investigate the interaction between NLRP12 and CUL3 in human cells and examine the role in regulating NF-κB signaling. Previously, co-immunoprecipitation, followed by western blot analysis, and confocal microscopy …


Activity Patterns Of The Critically Endangered Central American River Turtle (Dermatemys Mawii), Cora Dyslin Jan 2023

Activity Patterns Of The Critically Endangered Central American River Turtle (Dermatemys Mawii), Cora Dyslin

MSU Graduate Theses

The Central American River Turtle (Dermatemys mawii) is native to southern Mexico, eastern Guatemala, and Belize and is primarily restricted to watersheds that drain into the Gulf of Mexico and Caribbean Sea. Hunting, both for personal consumption and market meat, has been the primary driver of declines, and the species is now classified as critically endangered. Results from past studies that have used netting and visual surveys to detect D. mawii suggest that the species is chiefly nocturnal. However, it is unclear to what extent the perception of nocturnality has been biased by the timing of survey efforts …


Effects Of Lemongrass Essential Oil On Galleria Mellonella Hemocytes, Kyndra Chastain Jan 2022

Effects Of Lemongrass Essential Oil On Galleria Mellonella Hemocytes, Kyndra Chastain

MSU Graduate Theses

In modern agriculture, the use of pesticides is unavoidable. However, improper use has resulted in pest resistance and negative impacts on the environment and human health. Changes are needed in the agricultural industry to account for the damage already caused. Researchers have turned to essential oils as key ingredients for potential biopesticides, with some mixtures already on the market. Most studies involving essential oils and a pest’s response concentrate on mortality or interruptions in development during and between life stages. My study, however, focused on immune responses; specifically, lemongrass essential oil’s impact on Galleria mellonella. Such responses include a …


A Comparison Of The Magnitude Of The Mental Health Benefits Of Exercising Outdoors Vs Exercising Indoors: A Review, Greta M. Rueschmann Jan 2022

A Comparison Of The Magnitude Of The Mental Health Benefits Of Exercising Outdoors Vs Exercising Indoors: A Review, Greta M. Rueschmann

MSU Graduate Theses

Many people in the United States suffer from poor mental health which can lead to suicide, self-harm, or negative effects on job performance and relationships. Not everyone can afford traditional therapy nor feels comfortable with it. With a greater emphasis placed on taking care of one’s mental health during the COVID-19 pandemic, there should also be a greater emphasis placed on finding alternative types of therapy that can be matched to individuals based on their personalities and preferences. One such alternative is outdoor exercise. This review was conducted to examine whether exercising or performing physical activity outdoors results in greater …


Largemouth Bass In The Upper Mississippi River: An Evaluation Of Management Strategies And Understanding Potential Factors Influencing Dynamic Rate Functions, Kylie Beth Sterling Jan 2022

Largemouth Bass In The Upper Mississippi River: An Evaluation Of Management Strategies And Understanding Potential Factors Influencing Dynamic Rate Functions, Kylie Beth Sterling

MSU Graduate Theses

The Upper Mississippi River (UMR) supports ecologically and economically important commercial and recreational fisheries. One recreational fishery in the UMR is the Largemouth Bass fishery. Recreational fisheries can be effectively managed using information on population dynamics, though little is known about Largemouth Bass population dynamics in large river ecosystems. Therefore, the objectives of this study were to 1) evaluate recruitment, growth, and mortality of three Largemouth Bass populations in the UMR, specifically within Pools 4, 8, and 13, and 2) to use those estimates of recruitment, growth and mortality to inform exploitation models to evaluate best management practices for each …


Spatial And Temporal Heterogeneity Of Hyporheic Invertebrates In An Ozark Stream, David Fleshman Jan 2022

Spatial And Temporal Heterogeneity Of Hyporheic Invertebrates In An Ozark Stream, David Fleshman

MSU Graduate Theses

The hyporheic zone (HZ), an ecotone between surface water and groundwater in streams, provides extensive but underappreciated habitat for invertebrates in alluvial systems like the gravel-bed streams common in the Ozark highlands. Relative to its importance as a habitat, little is known about spatial distribution and response to disturbance by invertebrates in the HZ. In riffle-pool systems, surface water typically enters the HZ at the head of riffles (downwelling) and returns to the surface at the tail of riffles (upwelling). Previous research has found differences in invertebrate communities and environmental variables between upwelling and downwelling zones, but results have been …


Testing The Impact Of A Silencing Suppressor On Infectivity Of Grapevine Vein Clearing Virus Infectious Clone In Nicotiana Benthamiana, Wen Zhao Jan 2022

Testing The Impact Of A Silencing Suppressor On Infectivity Of Grapevine Vein Clearing Virus Infectious Clone In Nicotiana Benthamiana, Wen Zhao

MSU Graduate Theses

Grapevine vein clearing virus (GVCV), the first DNA virus of the Badnavirus genus discovered in grapevines, is closely associated with grapevine vein-clearing disease. Through earlier research, Koch's postulates were partially met: GVCV was in all diseased plants; GVCV was introduced into a healthy grapevine through grafting and by aphids and caused the disease. However, more shreds of evidence are required to fulfill the last postulate, the same virus must be reisolated from the inoculated diseased grapevine (1). A full-length infectious clone of GVCV was previously constructed to provide evidence; however, its infectivity was not consistent. Therefore, the goal …


Evaluating The Impact Of Off-Farm Decisions On Federal Government Program Utilization And Financial Success For Missouri's Beginning Farmers, Lyndsey Ann Parker Jan 2022

Evaluating The Impact Of Off-Farm Decisions On Federal Government Program Utilization And Financial Success For Missouri's Beginning Farmers, Lyndsey Ann Parker

MSU Graduate Theses

Farmers and ranchers will have to increase production by approximately 70% by the year 2050 according to the American Farm Bureau Federation (2017). People in the agriculture industry face several challenges from start-up costs to limited land availability (Ahearn, 2011). There are federal and state government programs available to assist with some of these challenges but bring their own hardships as well. This study measures off-farm decisions that affect financial performance and utilization of government programs for Missouri’s farmers and ranchers. Three types of financial performance of Missouri farms are prioritized in this study, liquidity (current ratio), solvency (debt-to-asset ratio), …


Identification Of A Novel Protein Interaction That Elucidates The Mechanism Of Idiopathic Recurrent Miscarriages In Women With Nlrp2 Mutations, Nayeon Son Jan 2022

Identification Of A Novel Protein Interaction That Elucidates The Mechanism Of Idiopathic Recurrent Miscarriages In Women With Nlrp2 Mutations, Nayeon Son

MSU Graduate Theses

The protein NOD-Like receptor pyrin domain containing 2 (NLRP2) is one member of a larger family of protein receptors that plays an important role in our innate immune system. In humans, the NLR family consists of 22 proteins. However, only about a half of NLRs’ functions are known, but many are pro-inflammatory, causing inflammation. NLRP2 has been identified to be a maternal effect gene regulating early embryo development in idiopathic recurrent miscarriages. In previous studies, mutations in the NLRP2 gene resulted in genetic maternal imprinting disorders due to NLRP2 regulating DNA methylation. However, the exact mechanisms involved in recurrent miscarriages …