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Young Adults' Awareness And Knowledge Of Human Papillomavirus, Oropharyngeal Cancer, And The Hpv Vaccine, Eric N. Davis

Electronic Thesis and Dissertation Repository

The Human Papillomavirus (HPV) is an extremely prevalent and sexually transmitted infection that is a known cause of morbidities such as genital warts and cancers of the cervix, anus, and oropharynx. Non-cervical HPV-related cancers have been a developing problem in North America, increasing in incidence by up to 225% in some instances over a span of two decades.

This study investigated levels of awareness and knowledge of HPV, Oropharyngeal Cancer (OPC), and the HPV vaccine using a self-administered web-based survey designed specifically for this research. University students (n=1,005) aged 18-30 completed a 42-item questionnaire that included demographic information, awareness questions, …

Atrx Loss-Of-Function In Mouse Neuroprogenitor Cells As A Model Of Early Events In Gliomagenesis, Hannah E. Goldberg

Electronic Thesis and Dissertation Repository

ATRX is a chromatin remodeling protein important for neural development, and ATRX inactivation leads to genomic instability, mitotic defects and TP53-mediated apoptosis. In the last few years, ATRX mutations were identified in a large proportion of paediatric and adult gliomas that often coincide with mutations in the tumor suppressor TP53. The present work shows that combinatorial loss of ATRX and TP53 function in vitro causes genomic instability while improving cell viability, identifying potential early events in gliomagenesis. Furthermore, several gene transcripts associated with glioma development and known oncogenic pathways were significantly upregulated in the Atrx-null neonatal mouse forebrain. …