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Electronic Theses and Dissertations

2018

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Daily Pork Consumption As A Part Of The Dietary Approaches To Stop Hypertension Diet Influences Body Composition And Preserves Muscle Mass In Older Adults Consuming Controlled Intakes, Alyssa Anne Kauffman Dec 2018

Daily Pork Consumption As A Part Of The Dietary Approaches To Stop Hypertension Diet Influences Body Composition And Preserves Muscle Mass In Older Adults Consuming Controlled Intakes, Alyssa Anne Kauffman

Electronic Theses and Dissertations

The purpose of this study was to test the hypothesis that muscular fitness is preserved in older adults who consumed pork daily as a part of the DASH dietary pattern. A controlled feeding pilot study was used to test this. Eight healthy older men and women were randomly assigned to consume either 3 ounces or 6 ounces of pork daily as a part of the DASH diet for a total of 12 weeks. Indicators of muscle mass, strength, and function were assessed at five time points (weeks 0, 3, 6, 9, 12) throughout the 12 weeks. A seven day cyclical ...


Eavesdropping On Gulf Of Maine Cetaceans In The Vicinity Of Mount Desert Rock, Christopher James Tremblay Dec 2018

Eavesdropping On Gulf Of Maine Cetaceans In The Vicinity Of Mount Desert Rock, Christopher James Tremblay

Electronic Theses and Dissertations

Passive acoustic monitoring, the recording and analysis of biological sound, is a standard method of research into the distribution and behavior of cetaceans worldwide. Acoustic monitoring is reliant upon a thorough reference catalog of species vocalizations and an understanding of the temporal and geographic parameters in which vocalizations occur. This study combined a standard cetacean passive acoustic monitoring survey with a concurrent visual survey at a known baleen whale summer feeding ground to determine the annual species and vocal composition, compare species detection rates using each method, and identify and attribute novel vocalizations to species. The survey took place at ...


Effects Of Increasing Temperature And Acidification On The Growth And Competitive Success Of Alexandrium Catenella From The Gulf Of Maine, Drajad Seto Dec 2018

Effects Of Increasing Temperature And Acidification On The Growth And Competitive Success Of Alexandrium Catenella From The Gulf Of Maine, Drajad Seto

Electronic Theses and Dissertations

The increases in ocean temperature and pCO2 due to climate change are projected to affect the growth and future prevalence of Harmful Algal Blooms (HABs) in nearshore waters, but systematic studies on the effects these climate drivers have on harmful algal species are lacking. In particular, little is known about how future climate scenarios will affect the growth of the toxic dinoflagellate Alexandrium catenella, which produces the toxins responsible for paralytic shellfish poisoning (PSP) that threaten the health and economy of coastal communities in the Gulf of Maine. I examined growth responses of A. catenella and two other naturally co-occurring ...


Developing Animal Feed Preservatives From Paper Mill Byproducts, Diana Carolina Reyes Gomez Dec 2018

Developing Animal Feed Preservatives From Paper Mill Byproducts, Diana Carolina Reyes Gomez

Electronic Theses and Dissertations

Our objectives were to evaluate the antifungal properties of technical lignins against 3 molds and 1 yeast causing hay spoilage, and for their ability to preserve alfalfa hay nutritive value. In experiment 1, 8 technical lignins and propionic acid (PRP; positive control) were tested at a dose of 40 mg/mL. The experiment had a randomized complete block design (RCBD, 4 runs) and a factorial arrangement of 3 molds × 10 additives (ADV). The effects of ADV on the yeast were also evaluated with a RCBD. Across fungi, sodium lignosulfonate (NaL) and PRP were the only treatments with a 100 ± 2 ...


Assessing The Upper Critical Limit Of The Thermoneutral Zone In Laboratory Mice, Teumbo Ngunte Dec 2018

Assessing The Upper Critical Limit Of The Thermoneutral Zone In Laboratory Mice, Teumbo Ngunte

Electronic Theses and Dissertations

Endothermic organisms such as mammals and birds rely on high energy budgets to regulate body temperature. Many studies have previously investigated the thermo-regulation of mammals under the lower critical temperature of the thermoneutral zone, yet our knowledge in determining the upper critical limits is still scarce. As an endotherm, lab mice (Mus musculus) are perfect models to determine the cost to maintain constant body temperature as ambient temperature increases. The upper critical temperature of the thermoneutral zone of this species has been estimated to be above 32°C and below 34°C. By utilizing different genetic backgrounds of lab mice ...


Teachers' Professional Knowledge And Formative Assessment Practices: An Empirical Study From Middle School Earth Science Instruction In The Context Of An Educational Improved Community, Laura Millay Dec 2018

Teachers' Professional Knowledge And Formative Assessment Practices: An Empirical Study From Middle School Earth Science Instruction In The Context Of An Educational Improved Community, Laura Millay

Electronic Theses and Dissertations

While there is widespread agreement that effective formative assessment supports student learning in science, the knowledge teachers need in order assess learning remains sparsely studied. In 1999, Magnusson, Krajcik, and Borko (MKB) proposed that Pedagogical Content Knowledge (PCK, Shulman 1986, 1987) is a distinct knowledge domain that synthesizes three base domains that include science subject matter, pedagogy, and context. The MKB model identified Assessment Knowledge as one of five components of PCK. Since 1999, several studies have used the MKB framework, but have left Assessment Knowledge underdefined. In 2012, Avargil, Herscovitz, and Dori proposed a revision based on empirical study ...


Characterization And Functional Rescue Of Congenital Muscular Dystrophy With Megaconial Myopathy In A Mouse Model Of The Disease, Ambreen A. Sayed Dec 2018

Characterization And Functional Rescue Of Congenital Muscular Dystrophy With Megaconial Myopathy In A Mouse Model Of The Disease, Ambreen A. Sayed

Electronic Theses and Dissertations

Congenital muscular dystrophy with megaconial myopathy (MDCMC) is an autosomal recessive disorder characterized by progressive muscle weakness and wasting. Megamitochondria in skeletal muscle biopsies and cognitive impairments in MDCMC patients are observations exclusive to this type of muscular dystrophy. The disease is caused by loss of function mutations in the choline kinase beta (CHKB) gene which results in dysfunction of the Kennedy pathway for the synthesis of phosphatidylcholine (PC). A rostro-caudal muscular dystrophy (rmd) mouse with a deletion in the Chkb gene resulting in MDCMC-like symptoms has been reported by our lab. In order to test if the rmd mice ...


The Infection Dynamics Of Sea Lice On Atlantic Salmon (Salmo Salar) In Cobscook Bay, Maine, Usa, Catherine Anne Frederick Dec 2018

The Infection Dynamics Of Sea Lice On Atlantic Salmon (Salmo Salar) In Cobscook Bay, Maine, Usa, Catherine Anne Frederick

Electronic Theses and Dissertations

Sea lice (Lepeophtheirus and Caligus spp) are parasitic copepods that infect the external surfaces of fish hosts. Salmon lice (L. salmonis) outbreaks are commonly reported by operations in Canada, Norway, Scotland, Ireland, and the United States and are a primary concern in aquaculture because of their fish health and economic impacts. When farmed fish mortalities and treatments are accounted for, annual losses from sea louse infestations exceed $300,000,000 (Costello 2009). Farms experiencing sea lice infections risk on-site re-infection and transmission to wild populations and other farms that are hydrographically connected. In Maine, Atlantic salmon farms are located in ...


Modeling Human Cancer Therapy Response In Patient Derived Xenografts, Joan Malcolm Dec 2018

Modeling Human Cancer Therapy Response In Patient Derived Xenografts, Joan Malcolm

Electronic Theses and Dissertations

Patient‐derived xenografts (PDXs) generated by implanting human tumor tissue into a transplant compliant mouse host have been of increasingly importance to preclinical development and have been demonstrated to have advantages compared to cancer cell lines and cell‐line xenografts (CLX) for modeling therapeutic responses in cancer. Nevertheless, many open questions remain regarding the relationship between study design factors and classification of treatment response and the molecular fidelity of tumors passaged in PDXs relative to the original patient tumor(s). The research described in this dissertation addresses both of these significant issues related to the use of PDXs as a ...


Investigations Into The Advancement Of Cryptotephra Geochemical Fingerprinting, Laura Hartman Dec 2018

Investigations Into The Advancement Of Cryptotephra Geochemical Fingerprinting, Laura Hartman

Electronic Theses and Dissertations

The primary purpose of this work is to advance new sample preparation and analytical methods for ice core tephrochronology. When a volcanic source can be accurately identified using volcanic glass particle geochemistry, it may provide a robust time reference for the ice core’s timescale. The presence of an identifiable tephra layer may also suggest atmospheric pathways at the time of deposition, or assist in reconstructing volcanic forcing of climactic state for a specific event. One of the perpetual challenges in ice core based tephrochronological work is measuring the geochemical composition of ultra-fine particles (<10 >μm). Not only is it difficult ...


An Exploratory Survey Of Factors Affecting Satisfaction With Educational Experiences For Parents Of Children With Cystic Fibrosis, Rebecca Perry Keenan Dec 2018

An Exploratory Survey Of Factors Affecting Satisfaction With Educational Experiences For Parents Of Children With Cystic Fibrosis, Rebecca Perry Keenan

Electronic Theses and Dissertations

Consumer satisfaction has been studied extensively as it relates to service seeking behavior, positive perceptions of services rendered, and measurable benefit as a result of service delivery. Furthermore, numerous studies have explored the importance of a strong, collaborative home-school partnership for student success. Additionally, previous research has identified children with chronic illnesses as a special population frequently requiring individualized accommodations and modifications to promote success in the educational environment, and therefore testing the limits of the educational system to adequately meet their needs. Finally, research has described the common sequelae of Cystic Fibrosis, including wide-ranging physical, behavioral, and functional consequences ...


Characterization Of G-Protein Coupled Receptors In Pain, Depression And Anxiety, Neil Lax Dec 2018

Characterization Of G-Protein Coupled Receptors In Pain, Depression And Anxiety, Neil Lax

Electronic Theses and Dissertations

Chronic pain and major depressive disorder are widespread conditions in the world. Interestingly, these conditions often occur comorbidly, with each individual disease amplifying the symptoms of the other. A significant amount of preclinical research in pain and depression focuses on G-protein coupled receptors (GPCRs), implying that GPCRs may be useful in treating this comorbidity. Our efforts have sought to characterize several poorly understood GPCRs, including the serotonin receptor subtypes 2C and 7 (5-HT2CR and 5-HT7R) and metabotropic glutamate receptor 5 (mGluR5), along with more well-known GPCRs such as the mu opioid receptor (MOR), and the role that they play in ...


Health Equity Through Spatial Justice: A Critical Phenomenology Of Urban Trail Makers, Arvin Simon Dec 2018

Health Equity Through Spatial Justice: A Critical Phenomenology Of Urban Trail Makers, Arvin Simon

Electronic Theses and Dissertations

Research has increasingly demonstrated that race, class and place are powerful predictors of health and social justice. This study was conducted to identify the lived experiences of individuals who were hired and trained as part of a green job program that created trails within a city park in Pittsburgh’s Mount Washington Community. This program has historically hired individuals who were formerly incarcerated, many of whom identify as African American. We explored the personal and social experiences of working in nature to better appreciate the intersections of race, class and environment in an urban community. This current study is based ...


Well-Trained Mentors: The Missing Component Of The Comprehensive New Teacher Induction Program In The Silver Oak Area School, Daniel Bosnic Dec 2018

Well-Trained Mentors: The Missing Component Of The Comprehensive New Teacher Induction Program In The Silver Oak Area School, Daniel Bosnic

Electronic Theses and Dissertations

“If well-trained, competent, caring teachers were present in every classroom, we would witness a staggering increase in student achievement, motivation, and character improvement along with a marked decrease in discipline problems” (Breaux & Wong, 2003, p.22). If school districts do not take the initiative to design and implement effective induction programs with embedded mentoring, they are essentially setting their teachers and students up for failure. Regardless of educator training programs, new teachers are unprepared to face the diverse and challenging needs of education today (Bartell, 2005). All individuals entering education need assistance in applying their prior knowledge and experience to ...


A Disability Theology Of Limits For Responding To Moral Injury, Lisa Hickman Dec 2018

A Disability Theology Of Limits For Responding To Moral Injury, Lisa Hickman

Electronic Theses and Dissertations

The lament of Jeremiah, “they dress the wound of my people as if it were not serious,” reverberates today as veterans return home from a decade of war, ridden by PTSD and moral injury, only to discover lethargy, lack of seriousness and complacency in societal response. The seriousness of our soldiers’ wounds, to body and spirit alike, demand ethical, societal and theological responsibility. Failure to address the seriousness of these wounds results in distress, depression and even suicide for the soldier. Statistics may describe a portion of the reality, but the degree to which soldiers suffer in silence and the ...


St. Augustine And The Rhetoric Of De Ordine, Natalie Gigliotti Dec 2018

St. Augustine And The Rhetoric Of De Ordine, Natalie Gigliotti

Electronic Theses and Dissertations

This study contributes to scholarship on the question of Augustine and rhetoric by considering Augustine’s use and understanding of rhetoric in De ordine, one of his early philosophical dialogues composed during his transition from a life in rhetoric to a life in philosophy. The author studies the text through consideration of Augustine’s rhetoric in relationship to three major rhetorical authorities of the time, particularly their cultural applications: sophistic rhetoric, Ciceronian rhetoric, and Christian rhetoric. Through study of these relationships, one perceives Augustine’s ingenuity at work as he integrates diverse authorities into his rhetoric of order (ordo) and ...


Non-Symbolic Exact Quantity Representation In A Language-Impaired Population, John Verbos Dec 2018

Non-Symbolic Exact Quantity Representation In A Language-Impaired Population, John Verbos

Electronic Theses and Dissertations

The linguistic relativity hypothesis argues that language influences non-linguistic cognition. One version of the hypothesis suggests that language is a set of tools or technologies that variously enhance or dampen an individual’s capacity to perceive and operate upon the world in certain ways. A domain in which this may be tested is number, where it is hypothesized that counting language allows us to bridge our innate capacities for recognizing small exact quantities (subitizing) and approximating quantities larger than three or four (analog magnitude estimation). To test this, previous studies have asked adult participants who have limited or no access ...


Cyberbullying, Relational, And Social Aggression, Latitia Lattanzio Dec 2018

Cyberbullying, Relational, And Social Aggression, Latitia Lattanzio

Electronic Theses and Dissertations

Cyberbullying is a relatively new phenomenon that has only begun to be significantly investigated within the last decade. To date, researchers have failed to develop a uniform definition or determine appropriate terminology. These deficits have inhibited a comprehensive understanding of the phenomenon. Although a comprehensive conceptualization of cyberbullying has yet to be established, the phenomenon has been recognized as a significant problem affecting our youth. Many of the existing studies are descriptive in nature and emphasize the need for more research. In an effort to drive future studies, many have postulated on the possible similarities between cyberbullying and traditional indirect ...


Four Phases Of Subjectivity: A Rhetorical And Phenomenological Analysis Of Aimé Césaire And Cahier D’Un Retour Au Pays Natal, Chelsea Binnie Dec 2018

Four Phases Of Subjectivity: A Rhetorical And Phenomenological Analysis Of Aimé Césaire And Cahier D’Un Retour Au Pays Natal, Chelsea Binnie

Electronic Theses and Dissertations

This dissertation project sets out to perform a rhetorical and phenomenological analysis of the subjectivity that Césaire portrays in his epic poem Cahier d’un retour au pays natal, or Notebook of a Return to My Native Land. Césaire published and republished Cahier four times in a 17-year period and the modified accounts of subjectivity presented in the lines of the poem mirrors that of Césaire’s own human subjectivity. Césaire poetically unleashes Cahier and his Négritude project in an effort to shift the geography of reason from its self-appointed European center, to create a liminal space for the totalized ...


Parent-Teacher Relationships In Cyber Charter Schools: 
Investigating The Quality Of The Parent-Teacher Relationship And Its Impact On Student Achievement, Theresa Henderson Dec 2018

Parent-Teacher Relationships In Cyber Charter Schools: 
Investigating The Quality Of The Parent-Teacher Relationship And Its Impact On Student Achievement, Theresa Henderson

Electronic Theses and Dissertations

K-12 online and blended learning initiatives have experienced unprecedented growth in the past decade and are fast becoming a mainstream option for today’s generation of learners. In 2016, over five million students were enrolled in K-12 full-time state virtual schools and all 50 states and the District of Columbia offered some form of online learning for K-12 students with even greater growth projections by 2020. While K-12 online learning has grown in popularity and demand, research-based investigations into successful teaching, learning and student support developments are limited.

There is reason to believe that the quality of the parent-teacher relationship ...


A Qualitative Inquiry Into The Systemic Influences Upon The Wellness Of Home And Community Based Counselor, Elizabeth Moore Dec 2018

A Qualitative Inquiry Into The Systemic Influences Upon The Wellness Of Home And Community Based Counselor, Elizabeth Moore

Electronic Theses and Dissertations

Home and community based counseling services have become instrumental to the treatment of children and adolescents struggling with mental illness. Counselors working in these systems of care face significant challenges in this unique setting. Most home and community based counselors (HCBCs) face these challenges as recent graduates, not having adequate preparation for the home setting, while receiving little supervision. HCBCs have reported feeling isolated and unsupported and question their effectiveness as counselors. Macchi, Johnson, and Durtschi’s (2014) results point to the importance of self-care to HCBC wellness, especially when the HCBC is lacking supervision. Yet, we are unable to ...


Beyond Enlightenment: The Evolution Of Agency And The Modularity Of The Mind In A Post-Darwinian World, Derek Elliott Dec 2018

Beyond Enlightenment: The Evolution Of Agency And The Modularity Of The Mind In A Post-Darwinian World, Derek Elliott

Electronic Theses and Dissertations

Working out of the social and philosophical revolutions from the Enlightenment, contemporary action theory has unwittingly inherited several Cartesian ideas regarding the human mind: that it is unified, rational, and transparent. As a result, we have for too long conceived of action as intimately bound up with reason such that to act at all is to act for a reason, leaving us with theoretical difficulties in accounting for the behavior of non-human animals as well as irrational behavior in human beings.

But rather than propose that such difficulties can be resolved by retreating to a pre-Enlightenment view of human nature ...


Community Pharmacists And Substance Use Disorders: Attitudes, Knowledge And Practices, Deepika Rao Dec 2018

Community Pharmacists And Substance Use Disorders: Attitudes, Knowledge And Practices, Deepika Rao

Electronic Theses and Dissertations

Background: Substance use disorder (SUD) is a serious health concern affecting a large proportion of the US population. Community pharmacists are well-positioned to prevent, screen, and provide appropriate treatment for SUD. Stigma towards these patients and SUD results in reduced quality of care as well as poor treatment outcomes. It is imperative that pharmacists have the appropriate knowledge of and attitude towards prevention, harm reduction and treatment to develop therapeutic relationships and improve their delivery of pharmacy services

Objective: To assess knowledge, practices (with an emphasis upon screening), stigma and general attitudes of community pharmacists towards SUD and evaluate the ...


Bullying Of Linguistically Diverse Learners: Results From The Youth Risk Behavior Survey, Jenna Woodarek Dec 2018

Bullying Of Linguistically Diverse Learners: Results From The Youth Risk Behavior Survey, Jenna Woodarek

Electronic Theses and Dissertations

Bullying is a serious phenomenon yielding significant consequences for youth who are victimized, often targeted due to their perceived level of difference from their peers. This “otherness” can often be amplified in minoritized populations, especially those which have multiple, cooccurring vulnerabilities to be targets of bullying. After a period of bullying rates decreasing in the US, special interest group inquiries found bullying rates to be on the rise again and reportedly motivated by ethnicity or race, immigrant status, and proficiency in the English language. The present research study aims to expand upon the existing pertinent literature base specific to the ...


The Influence Of Age, Gender, And Thiol Repletion In An In Vivo Model Of Lewy Body Disorders, Daniel Mason Dec 2018

The Influence Of Age, Gender, And Thiol Repletion In An In Vivo Model Of Lewy Body Disorders, Daniel Mason

Electronic Theses and Dissertations

Lewy body disorders are a family of neurological brain disorders associated with olfactory, motor, and cognitive deficits and are collectively defined as α-synucleinopathies, as they are characterized by hallmark “Lewy bodies” composed of aggregated, fibrillar α-synuclein. It is not certain but often posited that fibrillar α-synuclein seeds the progressive, self-propagating spread of Lewy pathology through neuroanatomical circuitry. Furthermore, the site of disease induction is still debated. In Aim I, we developed a novel protocol for generating reproducible and robust α-synucleinopathy in the limbic temporal lobe following infusions of preformed α-synuclein iv fibrils into the mouse olfactory bulb, which is frequently ...


Synthesis Of Novel 6-Substituted And 5-Substituted Pyrrolo[2,3-D] Pyrimidine Antifolates As Targeted Anticancer Therapies, Xinxin Li Dec 2018

Synthesis Of Novel 6-Substituted And 5-Substituted Pyrrolo[2,3-D] Pyrimidine Antifolates As Targeted Anticancer Therapies, Xinxin Li

Electronic Theses and Dissertations

The dissertation will give an introduction, background and current research progress in the areas of antifolates and chemotherapy of anticancer. The design and synthesis of classical 6- substituted pyrrolo[2,3-d]pyrimidines and 5-substituted pyrrolo[2,3-d]pyrimidines as potential antifolates have been described. The design variations include: methylated thiophene regioisomers, fluorinated phenyl regioisomers, thionyl regioisomers on the side chain of pyrrolo[2,3-d]pyrimidines. As a part of this study, a series of new compounds have been synthesized and characterized. Of these, ten final compounds were submitted for biological evaluation.


Identity Negotiation, Saudi Women, And The Impact Of The 2011 Royal Decree: An Investigation Of The Cultural, Religious, And Societal Shifts Among Women In The Saudi Arabian Public Sphere, Maha Alshoaibi Dec 2018

Identity Negotiation, Saudi Women, And The Impact Of The 2011 Royal Decree: An Investigation Of The Cultural, Religious, And Societal Shifts Among Women In The Saudi Arabian Public Sphere, Maha Alshoaibi

Electronic Theses and Dissertations

Historically, Saudi Arabian culture has been deeply rooted in tradition, religious customs, family-oriented structures, and gender derived expectations for men and women alike. Saudi Arabian culture emphasizes a patriarchal family structure where men financially provide for their family whereas women are expected to manage internal household duties such as raising children, upholding household affairs, and working within a limited scope of employment. The concept of Saudi Arabian women integrating into the public workforce has been a source of contention and debate for the last several hundred years. Due to recent changes in political and economic events, a royal decree issued ...


Using An In Vitro-In Vivo Correlation For The ‘Bioequivalence By Design’ Development Of An Immediate Release Carbamazepine Product, Douglas Steinbach Dec 2018

Using An In Vitro-In Vivo Correlation For The ‘Bioequivalence By Design’ Development Of An Immediate Release Carbamazepine Product, Douglas Steinbach

Electronic Theses and Dissertations

The quality of a drug product may be characterized by the consistency with which its indicated clinical effect, and safety profile, is experienced by the patient. The concept that such quality should be built into a product is at the core of the United States Food and Drug Administration’s (FDA) quality by design (QbD) initiative. This vision for pharmaceutical product development emphasizes the risk-based identification of critical quality attributes (CQA) which summarize a product’s performance, the efficient refinement of critical product/process parameters (CPP) that can affect such attributes, and the systematic development of CPP limits, which assure ...


Probiotic Use In Trauma Patients: A Pathway To Determining The Standard Of Care To Improve Outcomes, Heather Vitko Dec 2018

Probiotic Use In Trauma Patients: A Pathway To Determining The Standard Of Care To Improve Outcomes, Heather Vitko

Electronic Theses and Dissertations

The gut microbiome consists of normally non-pathogenic bacteria, viruses, and fungi. These friendly microbes serve to maintain GI barrier function and integrity, play a role in host nutrient and drug metabolism, immunomodulation, and prevent pathogenic bacteria from colonizing or causing disease. The importance of a healthy microbiome for the overall health of the host is just recently being appreciated within the medical and science communities. Disruption of the microbiome places one at greater risk for illness and infection. Patients who suffer a traumatic injury are among those at highest risk for complications associated with microbial imbalance, or dysbiosis. In addition ...


Externality In Hegel's Philosophy Of Nature, Martin Krahn Dec 2018

Externality In Hegel's Philosophy Of Nature, Martin Krahn

Electronic Theses and Dissertations

The topic of my dissertation is the metaphysics of laws of nature in Hegel’s philosophy of nature. I argue that Hegel differentiates laws of nature from norms of culture through a concept of “externality,” according to which the universals or laws of nature stand outside of, apart from, independent from their particulars. He contrasts this with norms of culture, where the universals are internal to the particulars, such that in culture the particular events or actions shape the norms, whereas in nature, the laws remain the same through their independence from the particular events. I then address the consequences ...