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Studies Of The Effects Of Pancreatic Beta Cell Antioxidant Transgenes On Experimental Models Of Diabetes., Hainan Chen
Studies Of The Effects Of Pancreatic Beta Cell Antioxidant Transgenes On Experimental Models Of Diabetes., Hainan Chen
Electronic Theses and Dissertations
Pancreatic beta cells are extremely vulnerable to the destruction of Reactive Oxygen Species (ROS). In both type 1 and type 2 diabetes ROS are involved in the loss of U+000DF-cells. We hypothesized that the deficiency in ROS detoxifying system of U+000DF-cells resulted in U+000DF-cell vulnerability and enhanced ROS protection would protect from diabetes. To test this hypothesis, transgenic mice with overexpression of U+000DF-cell antioxidant protein metallothionein (MT), manganese superoxide dismutase (MnSOD) and catalase were produced on an FVB background. Initial studies demonstrated that these transgenes did not affect U+000DF-cell normal function and morphology. But those transgenes significantly protected pancreatic islets …
Increasing Diabetes Awareness In Adolescents Through Educational Programs., Sandra J. Reese
Increasing Diabetes Awareness In Adolescents Through Educational Programs., Sandra J. Reese
Electronic Theses and Dissertations
The purpose of this study was to increase knowledge of diabetes and promote healthy lifestyle behaviors to reduce diabetes onset in a community with a relatively high incidence of type 2 diabetes. Three hundred eighty seven students grades 7 – 12 participated in the program and taste test. Changes in knowledge before and after an educational program focusing on diabetes prevention were measured by comparison of identical pre, post, and retention tests. Students were also asked to name specific behaviors they could use to decrease the risk of diabetes. Responses were analyzed using Chi square analysis and content analysis. Overall, …