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The Importance Of Cmos Sensor Surface Topography In The Attachment, Proliferation, And Differentiation Of Human Adult Mesenchymal Stem Cells, Christa Y. Heyward
The Importance Of Cmos Sensor Surface Topography In The Attachment, Proliferation, And Differentiation Of Human Adult Mesenchymal Stem Cells, Christa Y. Heyward
Electronic Theses and Dissertations
Osteoblasts and osteoblast precursor cells (mesenchymal stem cells) respond to the surface topography of metal implants by aligning along surface features in order to minimize shear stress. While several previous studies have investigated the morphology, attachment and proliferation of both osteoblasts and mesenchymal stem cells along grooved surfaces, the current study investigates the cellular response to depressions and peaks in surface topography, as well as surfaces that contain alternating combinations of depressions and peaks. The Complementary Metal Oxide Semiconductor (CMOS) sensor is a transducer fabricated from silicon and sputter coated with titanium. The CMOS sensor is designed to utilize piezoresistive …