Digital Commons Network^™

Examining The Relations Between Obsessive Compulsive Disorder And Quality Of Life In A Transdiagnostic Eating Disorder Sample., Madison Rose Ortman

College of Arts & Sciences Senior Honors Theses

Background: Eating disorders (EDs) are life threatening psychological disorders characterized by obsessions related to food, weight, and exercise. The presence of an eating disorders has been linked to poorer quality of life (QOL) and clinical impairment. Obsessive compulsive disorder (OCD) is a psychiatric disorder characterized by intrusive thoughts and ritualistic behaviors. EDs and OCD have similar symptom structure as well as similar independent relationships to QOL. The present study aimed to validate these relationships and extend the findings into a more fine-grained symptom analysis of the relationship between EDs, OCD and QOL. Method: Participants (N = 109) were those …

Impact Of Lyophilization On Porcine Hemoglobin Properties., Mustafa Almosawi

College of Arts & Sciences Senior Honors Theses

Blood transfusion is the single most often performed lifesaving procedure in hospitals worldwide. Unfortunately, packed red blood cells (RBCs) used for transfusion can only be stored for 42 days at 4 °C before being discarded due to irreversible damage that occurs during storage. Any reduction in available RBCs for an extended period can lead to blood shortages. To increase the shelf-life of RBCs, we investigated freeze-drying (lyophilizing) in the presence of the non-toxic sugar trehalose as a method for long-term preservation. However, the oxidative stress of the lyophilization and storage processes can compromise the functionality of these cells, and the …

Diversification And Convergence Following The Transition From Saltwater To Freshwater In Stingrays., Autumn D. Magnuson

College of Arts & Sciences Senior Honors Theses

One of the most fundamental questions in biology is why some groups of organisms are more diverse than others. Classic hypotheses for explaining differences in diversity consider distinctions in time, place, resources, and competitors as the staging grounds for differential diversification. Freshwater and saltwater environments have similar levels of diversity despite significant differences in size, so studying transitions between the two systems can provide insights into evolutionary processes. Despite the challenges associated with this transition, stingrays have invaded freshwater habitats multiple times across different continents, making them useful for better understanding these systems. In this study, I evaluated the frequency …

The Lost Cause And The Commonwealth: The United Daughters Of The Confederacy And Forging Civil War Memory In Kentucky., Emma Donaghy

College of Arts & Sciences Senior Honors Theses

For over a century, the Kentucky division of the United Daughters of the Confederacy has worked to instill the Lost Cause myth of the Confederacy in the state’s public schools, libraries, and places where a white child could learn about the past. Few scholars have studied the activities of the Kentucky division of the UDC, although some of the organization’s most influential work took place in the state, and the organization’s national founder, Caroline Meriwether Goodlett, was born in Todd County, Kentucky. This honors thesis offers an in-depth examination of the work of the Kentucky division, drawing from the rich …

Osteoimmunology And The Reconstruction Of Host Immunological Status In Treponemal Infection: Effect Of Activated Immune Cells By Oral Pathogens And Treponema Pallidum On Osteoclastogenesis., Michayla Gatsos

College of Arts & Sciences Senior Honors Theses

Syphilitic infection caused by bacterium Treponema pallidum pallidum (Tp) offers an excellent model to study the long-lasting interplay between the immune and skeletal systems and could be used to reconstruct host immunological status. We propose that a hyper-inflammatory phenotype developed during acquired syphilis will have a systemic impact on most bone microenvironments involving inflammatory processes, such as the one developed in periodontal disease (PD). Using osteoimmunological in vitro protocols, we explore whether immune activation by Tp antigens and PD pathogens can impact osteoclastogenesis (OCG), ultimately helping to understand the bone alterations caused by systemic inflammatory processes in skeletal material. We …

Other Bodies: Deconstructing Visual Binaries By Subverting Visual Representations Of The Other., Amaiya L. Crawford

College of Arts & Sciences Senior Honors Theses

The goal of creating my sculptural work, The Avian, is both to broaden the visual categorization of sentient bodies, as well as to deconstruct binary thinking regarding the way that bodies display racialized, gendered, and sexualized characteristics. The Avian does this by subverting visual and aesthetic tropes that construct labels like human, monster, and animal. Subversion acts as the main design influence that illustrates how the display how othered bodies can be used to highlight the constructed nature of how we construct humanity. This paper posits that by acknowledging an expansion in visual categorization, in addition to further pushing opportunities …

The Emerging Oral Pathogen, Filifactor Alocis, Modulates Antimicrobial Responses In Primed Human Neutrophils., Ian J. Snider

College of Arts & Sciences Senior Honors Theses

Periodontitis is an irreversible, chronic inflammatory, infectious disease of the oral cavity that affects approximately half of all adults 30 years or older in the USA. The oral cavity is under high immune surveillance because of its constant exposure to microbes in the environment. The primary immune cell responsible for this surveillance is the neutrophil. Pathogens associated with periodontitis possess virulence factors and have evolved strategies to evade neutrophil antimicrobial responses to survive. One such pathogen is Filifactor alocis, whose presence is associated with the progression of periodontitis. F. alocis manipulates several neutrophil antimicrobial functional responses to avoid killing, an …

Understanding The Role Of Emotion Regulation Tendencies In The Momentary Associations Between Negative Affect And Eating Disorder Behaviors., Coby D. Banet

College of Arts & Sciences Senior Honors Theses

Background: Eating disorders (EDs) are becoming increasingly commonplace and are associated with a broad array of dangerous medical complications. Further, EDs frequently present alongside comorbid psychiatric disorders (e.g., depressive and anxiety-related disorders), which are known to both predict ED severity and reduce treatment efficacy. While diagnostic categorization persists, Fairburn et al.’s (1993) transdiagnostic model suggests EDs may be more closely related and maintained through core, shared symptoms. To assess ED maintenance, momentary triggers such as negative affect (NA) are becoming increasingly centralized. The present study examines the roles of depressive symptoms and worry in predicting and moderating the relationships among …

Azanyl Carbamates: Synthesis, Characterization And Chemistry., Maunil Mullick

College of Arts & Sciences Senior Honors Theses

Azanyl carbamates are an understudied, rarely-reported class of compounds in the organic chemistry literature. The azanyl carbamate moiety contains both a carbamate and an amine functional group. As such, this class of compounds features a high ratio of heteroatoms (atoms that are not carbon or hydrogen) relative to carbon: a characteristic of many natural and synthetic organic catalysts.¹ Another reason we are particularly interested in azanyl carbamates is the fact that the amine is incorporated as an aminooxy group. An aminooxy group consists of an amine directly connected to an oxygen atom. The aminooxy group is of special interest …

Histological Evaluation Of Offspring Kidneys Following Prenatal Vaping Exposure., Lucas Georges

College of Arts & Sciences Senior Honors Theses

A variety of nicotine-containing products have been making their way to the market as alternatives to cigarette smoking. These include, but are not limited to, cigars, pipes, smokeless tobacco, and electronic cigarettes, with the last one being more prevalent than the others. With these alternatives, there are more tobacco users now than ever, with an increase from 1990 to 2017, which contrasts with the reduction in number of smokers observed by the Surgeon General in his Smoking Cessation report between 1990 and 2017, meaning that more and more tobacco users are using these. Pregnant women are advised to switch from …

The Effects Of Prescribed Fire On Ant Community Composition In A Temperate Deciduous Forest., Emma Jones

College of Arts & Sciences Senior Honors Theses

Prescribed fire is a tool commonly used in land management to decrease wildfire frequency and promote plant diversity. However, the effects of prescribed fire on invertebrate communities, especially those within temperate deciduous forest, are poorly understood. I measured the response of epigeic ant communities in mixed mesophytic forest in Berea, Kentucky following prescribed burning. I used pitfall traps to repeatedly sample epigeic ants in replicate burned and unburned plots for up to 21 months postburn following two separate (2021 and 2022) prescribed fires. Ant species richness was similar between treatments (burn vs. control) and by burn year. Ant community composition …

An Emergentist Critique Of The Contract Theory Of The State Of Nature, With A Consideration On Two Types Of Polity And Their Origins., Ryan A. Apperson

College of Arts & Sciences Senior Honors Theses

The theories of the state of nature provided by the political philosophers Thomas Hobbes and John Locke have made a significant impact in the general conceptions of the origin of states. Though there are many critical differences in the conceptions of the state of nature between each in their seminal works, they both possess of a view of states that is rational and constructivist.

In this paper, I use the game theory concepts of the coordination game, collective action problem, and focal point to illustrate a lacuna in this rational and constructivist conception of the origin of states, as their …

Impacts Of Dietary Restriction On A Drosophila Model Of Werner Syndrome, Eileen Sember

College of Arts & Sciences Senior Honors Theses

Werner syndrome (WS) is an autosomal recessive disorder that results in premature aging and occurs in 1 in 1,000,0000 to 1 in 10,000,000 people. In humans, WS is the result of mutations that render the WRN gene, that contains a helicase and an exonuclease domain, non-functional. Currently, there is no cure for WS in humans, making dietary and lifestyle interventions attractive for increasing the quality and longevity of lives. Diet restriction (DR) has been shown to extend the lifespan of several model organisms, including Drosophila melanogaster, making it a strong candidate for WS treatment. In this thesis, mutant flies …

Understanding The Evolution Of Enforcement Systems In Resource Dilemmas, Devin M. Flener

College of Arts & Sciences Senior Honors Theses

The effective management of resources on Earth is a pressing global social dilemma. An alternative solution to the traditional managing methods of these common pool resources is communal self-management facilitated through principles of restorative justice and developed through exploratory learning. We examined how communication, restorative justice techniques, and opportunity for exploratory learning impacted groups’ ability to develop a strong conceptual understanding of enforcement as well as an enforcement system in order to maintain an effective conservation strategy. Participants (N=288) were randomly assigned to 72 four-person groups in six separate conditions. Each group played nine rounds of a computer-simulated foraging task …

Impacts Of Bacterial Evolution On Host Lethality In Drosophila, Andrew Preston

College of Arts & Sciences Senior Honors Theses

Evolution is the process by which species change their genetic traits, such as the pathogenicity of bacteria, over time in response to changes in their environment. Although the genetic mechanisms underlying many evolutionary processes have been revealed, it is still not well understood how opportunistic pathogens, such as Pseudomonas aeruginosa, become virulent. The overall goal of this thesis is to test the Coincidental Evolution Hypothesis, which proposes that the virulence of opportunistic pathogens evolves coincidentally as a by-product of their interaction with their natural predators. I hypothesized that the virulence of ancestral Pseudomonas aeruginosa changes over time if it co-evolves …

The Philosophy Of Activism And Its Paradox., Omar Arar

College of Arts & Sciences Senior Honors Theses

Activist organizations have been at the forefront of countless progressive efforts, seeking to ameliorate social injustices, expand the rights of marginalized people, and strengthen democratic institutions. However, the efforts of activists always seem to lead to incremental victories or a minimal change to the status quo. In this paper, I argue that the primary cause of this largely stagnant social justice landscape is the professionalization of activism. Activism in its professional form, as people who make a living out of their activist efforts, brings with it numerous issues, the most problematic among them is the manifestation a paradox. Namely, professional …

The Loneliest Galaxies In The Universe: A Gama And Galaxy Zoo Study On Void Galaxy Morphology., Lori E. Porter

College of Arts & Sciences Senior Honors Theses

The large-scale structure (LSS) of the Universe is comprised of galaxy filaments, tendrils, and voids. The majority of the Universe’s volume is taken up by these voids, which exist as underdense, but not empty, regions. The galaxies found inside voids are void galaxies and expected to be some of the most isolated objects in the Universe. However, their standard morphology remains poorly studied. This study, using the Galaxy and Mass Assembly (GAMA) data and Galaxy Zoo survey, aims to remedy this. For completeness purposes, we use void galaxies identified by Alpaslan et al. (2014) with stellar masses (M*) of 10 …

Interpreting San Cecilio: Ritual And Discourse In A Granadan Celebration., Martha M. Popescu

College of Arts & Sciences Senior Honors Theses

The romería de San Cecilio is an annual, local short pilgrimage and celebration of the patron saint of Granada, a city in Andalusia, Spain. The romería takes place at the Abbey of Sacromonte, a monastery built on top of the site where San Cecilio’s remains were found as part of the famous discoveries of the Lead Books of Granada in the late sixteenth century. These books were ultimately declared to be Islamic forgeries, yet the romería persists today as a granadino, or Granadan, tradition. Consisting of both a Mass at the Abbey as well as a popular celebration, the …

Immobilization And Its Effects On Functional Recovery After Spinal Cord Injury., William H. Gregory

College of Arts & Sciences Senior Honors Theses

Recovery, or rather the failure to recover, is a perplexing issue of spinal cord injury that is currently being investigated. This issue becomes more puzzling when investigating models in which spinal cord injury (SCI) is studied. There appears to be greater functional recovery experienced by animals within these models after injury as compared to patients in the clinical setting. While many things could contribute to this disparity, one difference that stands out when comparing the basic research model and clinical experience of SCI is the inactivity and limb disuse after the injury. This same level of immobility is rarely accounted …

Aha! Examining Insight In Exploratory Learning Versus Traditional Instruction., Olivia Kaiser

College of Arts & Sciences Senior Honors Theses

In undergraduate classrooms, students are typically first taught the concepts and procedures for solving problems, then practice. With exploratory learning methods, students explore novel problems and generate original solutions before receiving instruction, which benefits conceptual understanding and future learning. The current study examined whether students who explore before instruction experience greater insight moments, and whether insight leads to better learning. Prior research demonstrates that individuals remember problem solutions better if they experience a sudden moment of solution clarity (Aha! Experience). Participants (N = 83) were randomly assigned to instruct-first or explore-first conditions and taught three types of magic tricks …

The Purpose Of Hell: Control Of Communities Through Apocalyptic Literature., Madison S Fogle

College of Arts & Sciences Senior Honors Theses

Literature depicting Hell in late antique Christianity reveals more than the theological concern for one’s eternal soul, revealing the underlying values and morals of the growing society. Borrowing from Roman, Greek, and Jewish culture, Christians were seeking to set themselves apart while also grappling with their past around them. Through visions of Hell, apocalyptic literature in late antique Christian society exhibits the control exercised over parishioners, specifically control over their bodies and their wealth. The moral laws from Greek, Roman, and Jewish influences is evident through early Christian literature, which dictate the ways in which people are regulated by Christianity …

Creolization And Romanity: The Continuities And Changes Of Roman Egypt., Travis M. Kaelin

College of Arts & Sciences Senior Honors Theses

Past scholarship has analyzed Roman Egypt through the process of Romanization, but my research evaluates the province through creolization instead. The process of creolization is complex but affords indigenous populations more agency than terms like romanization. The thesis addresses the Egyptian and Greek continuities in language, religion, and way of life to display the extent of creolization. Analysis of Roman Egypt through the post-colonial lens better represents the changes that took place and the intent of the Roman principate. Much of the research derives from papyrological and archaeological sources to create a more nuanced understanding of what Roman Egypt looked …

Functional Characterization Of A Putative Alternative Oxidase In Sporisorium Reilianum F. Sp. Zeae., Emma A Lamb

College of Arts & Sciences Senior Honors Theses

Sporisorium reilianum is a pathogenic basidiomycete fungus with two formae speciales, each capable of infecting corn (SRZ) or sorghum (SRS), respectively. This fungus is also a dimorphic variety, meaning it can switch between its haploid, yeast-like sporidia and diploid teliospore stages over the course of its life cycle (Schirawski). When S. reilianum is found in a haploid state and conditions are favorable, it will mate with a compatible non-self mating type to begin filamentous growth and proliferation in the plant host (Zhao). S. relianum, like most fungi, utilizes the four classical components of the electron transport chain to produce …

The Great Resignation: A Content Analysis Of News Sources' Portrayals Of The Covid-19 Labor Shortage., Mackenzie Williams

College of Arts & Sciences Senior Honors Theses

When workers left the labor market in large numbers during the COVID-19 pandemic, proclamations of a labor shortage emerged extensively throughout the news. In this study, I analyze the coverage of the worker shortage among three news sources with different political orientations. Several themes emerged from analyzing a total of 75 articles. The findings showed that the perspective shown in the article, the cause of the labor shortage, restaurant worker portrayal, support of solutions, and opinion of the labor shortage all differed based on the political identity of the news source. This research supports previous findings that show there is …

The Interaction Of Spaced Retrieval Practice And Element Interactivity., Cameron K. Mattingly

College of Arts & Sciences Senior Honors Theses

Our study investigates the interaction of retrieval practice and element interactivity. Spaced practice is the process of breaking up the retrieval of information into smaller chunks across a longer period of time as opposed to learning everything in one time block. Retrieval practice is the process of testing yourself on previously learned material. Spaced retrieval practice is the merger of these two ideas. This style of learning is well-suited for learning many items that must be retained indefinitely (Lyle et al., 2019). Element interactivity describes the amount of learned items (elements) that are interrelated and must be processed together in …

The Madwoman In The Refrigerator And A Song Of Ice And Fire., Alex Herm

College of Arts & Sciences Senior Honors Theses

There is an existing trope in the fantasy genre I call the madwoman in the refrigerator—in which a female character is killed, maimed, raped, depowered, and/or made to go mad or insane when she is no longer able to uphold the conventional genre expectations of her role in the narrative, such as the angel, monster, or angelic monster. It is a combination of the theory from Sandra Gilbert and Susan Gubar that women are demure angels when they are fulfilling stereotypical feminine roles in a narrative and when desire or agency is found, the woman is a monster, portrayed as …

Evaluating Sex-Dependent Changes In The Gut Microbiome Caused By Polychlorinated Biphenyl (Pcb) Exposure., Zayna Qaissi

College of Arts & Sciences Senior Honors Theses

Polychlorinated biphenyls (PCBs) are persistent organic pollutants that have been associated with fatty liver disease, cardiovascular diseases, and other metabolic dysfunctions. Our laboratory group previously demonstrated that exposures to PCBs led to sex-dependent liver outcomes with female mice showing higher susceptibility to PCB- induced liver toxicity. Some of the underlying mechanisms driving these sex-dependent outcomes that were identified included PCB-modulated endocrine disruption. However, the PCB effects on the gut microbiome and the gut liver axis have not been investigated. Therefore, the objective of the current study is to identify PCB-induced changes in the gut microbiome and identify if this could …

Nitrogen Availability In Dune Systems And Its Effect On Root Fungal Endophyte Communities., Haley E. Sage

College of Arts & Sciences Senior Honors Theses

As global change persists, changes in resource availability can influence plant-microbe interactions. To understand how resource availability can influence these interactions and species diversity, I focused this research on how varying nitrogen (N) levels affect root endophyte communities in the plant species Ammophila breviligulata, an ecosystem engineer in the dune system. I analyzed the relationship between nitrogen addition and microbial community composition across 60 plots treated with three nitrogen addition levels (control, low, and high) in a long-term experimental field site in the Lake Michigan dunes. I identified Ammophila breviligulata's root endophyte community after creating a culture collection and …

The Yellow Figment Of East Asian American Women: A Case Study Of The 2021 Atlanta Spa Shootings., Lily Zhen-Ling Stewart

College of Arts & Sciences Senior Honors Theses

This paper explores how mainstream media frames the racial gendering of Asian women through a case study of the 2021 Atlanta Spa Shootings. Fifteen articles sourced from the top ten national newspaper entities published between March 16th, 2021 and October 2021 analyze how Asian American women are subjected to at least a double feminized social location on account of their race and gender within a U.S. contemporary context. I explore how themes of race, gender, and hyper-sexualization intersect to produce the archetype of Asian women as exotic, docile temptresses. This analysis centers around the dynamic between Asian women and White …

Using Fluorescent Microscopy To Follow Mitochondrial Inheritance Through Tagged Alternative Oxidase In Sporisorium Reilianum., Luke Schroeder

College of Arts & Sciences Senior Honors Theses

Sporisorium reilianum is a dimorphic fungus that inhabits and infects a host corn plant (Zea mays). In order for the fungus to reproduce sexually, compatible haploid mating types must form a dikaryon that goes on to cause infection in the host. This infection causes leaf chlorosis and gall formation, while ultimately allowing for the dispersal of fungal teliospores in the later stages of infection. To grow, the fungus requires energy production in the form of ATP from its mitochondria. As a countermeasure to infection, host plants release harsh reactive oxygen species that may damage DNA, lead to apoptosis, …