Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

PDF

Theses/Dissertations

Washington University in St. Louis

2019

Discipline
Keyword
Publication

Articles 1 - 30 of 307

Full-Text Articles in Entire DC Network

Affective Misattribution Following Memory Decisions Does Not Transfer To Interleaved Items, David Grybinas Dec 2019

Affective Misattribution Following Memory Decisions Does Not Transfer To Interleaved Items, David Grybinas

Arts & Sciences Electronic Theses and Dissertations

The outcomes of memory search appear to have affective consequences. For instance, during recognition memory tests, concluding that a retrieval probe is from a prior study period (‘old’) leads to higher pleasantness ratings for the probe than concluding it is novel (‘new”). Grybinas, Kantner, and Dobbins (2019) explained this and related findings via a Confirmation of Search (COS) hypothesis that assumes that the affective consequences of successful versus failed episodic retrieval are misattributed to probes used to elicit memory search. While these affective misattributions clearly occur for the memory probes themselves (within-item misattribution), social psychological research has previously shown that …

Go to article

Accuracy Matters For The Benefits Of Sleep After Retrieval Practice, Steven Dessenberger Dec 2019

Accuracy Matters For The Benefits Of Sleep After Retrieval Practice, Steven Dessenberger

Arts & Sciences Electronic Theses and Dissertations

Previous research suggests that while sleep and retrieval practice can each improve memory on their own, their benefits cannot be combined to produce an additive effect unless feedback is given during the initial test. These previous findings would seem to support a retrieval-as-consolidation of the testing effect, which states that the benefits of retrieval are the result of memory consolidation, a process that normally occurs during the sleep cycle. The present study sought to determine whether the retrieval-as-consolidation account held true when initial test accuracy was considered as a factor. Using foreign language word pairs, we examined the combined effects …

Go to article

Vega, Capital Ratios, And Real Estate Lending, Muna Alsheikh Dec 2019

Vega, Capital Ratios, And Real Estate Lending, Muna Alsheikh

Doctor of Business Administration Dissertations

The 2007 financial crisis revealed how excessive bank risk threatens financial system stability. This paper studies two aspects of the risk-taking incentives of banks– CEO compensation and capital. The vega of a bank executive’s equity compensation measures how compensation changes relative to the banks’ stock volatility. If CEO compensation vega is high, I expect the CEO to take more risk in areas where he exercises control. Conversely, if regulators demand that banks invest their own capital to encourage conservative behavior, then I expect risk-taking to be lower. This paper confirms that higher vega and lower capital ratios are associated with …

Go to article

Children's Perceptions Of Status At The Intersection Of Race And Gender, Grace Reid Dec 2019

Children's Perceptions Of Status At The Intersection Of Race And Gender, Grace Reid

Arts & Sciences Electronic Theses and Dissertations

By 6 years of age, children associate males with higher status than females (Liben, Bigler & Krogh, 2001), and Whites with higher status than Blacks (Bigler, Averhart & Liben, 2003). However, little is known about how race and gender interact to influence children’s thinking about status. In Study 1, we asked whether children associate White men with higher status than other races and genders. Sixty children selected from among Black and White male and female targets the person who they thought would do familiar and novel jobs that varied in status. White men were the most likely to be chosen …

Go to article

Fear Of Positive Evaluation And Negative Affect From Inclusion In Cyberball, Jason Ted Grossman Dec 2019

Fear Of Positive Evaluation And Negative Affect From Inclusion In Cyberball, Jason Ted Grossman

Arts & Sciences Electronic Theses and Dissertations

Fear of positive evaluation (FPE) is a construct related to social anxiety that involves discomfort when receiving positive attention and feedback from others. FPE research has increased over the past decade, and results suggest that it may be an important part of social anxiety for some individuals; however, it is not yet known whether FPE may also include discomfort from being included in social situations. Level of inclusion was hypothesized to moderate the relationship between FPE and negative affect from being over included such that those with high FPE would feel more uncomfortable the more they were included. To test …

Go to article

The Scaffolds To Guide Fast Angiogenesis, Tianhong Zhou Dec 2019

The Scaffolds To Guide Fast Angiogenesis, Tianhong Zhou

McKelvey School of Engineering Theses & Dissertations

Angiogenesis is one of the most challenging problems in bone structure repair. The different types of 3D fibrous morphology structure of the extracellular matrix for fasting angiogenesis have been studied. Due to the densely packed constructs and limited porosity of scaffold, the challenge still remains for scaffold fabrication. In this study, we fabricated PCL scaffold with growth factors and cells to guide fast angiogenesis by electro-spinning and electro-spray simultaneously. We developed a technique that electro-spinning encapsulates growth factors OPN(Recombinant Human Osteopontin) and SDF-1α(CXCL12) in poly(lactide-co-glycolide) (PLGA) microspheres into PCL 3D structures scaffold fibers. We also developed a new technique to …

Go to article

Structural And Tissue-Level Adaptations Of Lumbar Intervertebral Discs In Humans With Inducible Low Back Pain Symptoms, Christian Isaiah Weber Dec 2019

Structural And Tissue-Level Adaptations Of Lumbar Intervertebral Discs In Humans With Inducible Low Back Pain Symptoms, Christian Isaiah Weber

McKelvey School of Engineering Theses & Dissertations

Low back pain (LBP) is a devastating musculoskeletal ailment that impacts majority of the global population. Up to 95% of cases are considered nonspecific where the origin is unclear. Although there is a diagnosis with these cases, there lacks specificity that would help individuals with treatment and pain management. Imaging techniques such as magnetic resonance imaging (MRI) are primarily utilized in the diagnosis of LBP as it illuminates internal structures of the spine. One important structure clearly identified with MRI is the intervertebral disc (IVD) that is susceptible to injury and disease. Further, diagnostic imaging is performed lying down where …

Go to article

A Microfluidic Platform To Investigate The Mechanism By Which Gdnf Overexpression In Schwann Cells Causes Neuronal Axon Entrapment, Ze Zhong Wang Dec 2019

A Microfluidic Platform To Investigate The Mechanism By Which Gdnf Overexpression In Schwann Cells Causes Neuronal Axon Entrapment, Ze Zhong Wang

McKelvey School of Engineering Theses & Dissertations

Twenty million Americans suffer from peripheral nerve injury (PNI) caused by trauma and medical disorders, with approximately $150 billion spent in annual health-care dollars in the United States. Even with proper surgical reconstruction, less than 50% of the patients achieve satisfactory functional recovery. The gold standard surgical repair for long gaps (>3cm) is the autologous nerve graft, despite its disadvantages such as donor site morbidity, risk of infection, and increased cost. Alternative methods, such as acellular nerve grafts (ANA), are ineffective for large lesion gaps because of the lack of cells and regeneration factors. Recent efforts have been focused …

Go to article

Graph Deep Learning: Methods And Applications, Muhan Zhang Dec 2019

Graph Deep Learning: Methods And Applications, Muhan Zhang

McKelvey School of Engineering Theses & Dissertations

The past few years have seen the growing prevalence of deep neural networks on various application domains including image processing, computer vision, speech recognition, machine translation, self-driving cars, game playing, social networks, bioinformatics, and healthcare etc. Due to the broad applications and strong performance, deep learning, a subfield of machine learning and artificial intelligence, is changing everyone's life.Graph learning has been another hot field among the machine learning and data mining communities, which learns knowledge from graph-structured data. Examples of graph learning range from social network analysis such as community detection and link prediction, to relational machine learning such as …

Go to article

Towards Interpretable Machine Learning With Applications To Clinical Decision Support, Zhicheng Cui Dec 2019

Towards Interpretable Machine Learning With Applications To Clinical Decision Support, Zhicheng Cui

McKelvey School of Engineering Theses & Dissertations

Machine learning models have achieved impressive predictive performance in various applications such as image classification and object recognition. However, understanding how machine learning models make decisions is essential when deploying those models in critical areas such as clinical prediction and market analysis, where prediction accuracy is not the only concern. For example, in the clinical prediction of ICU transfers, in addition to accurate predictions, doctors need to know the contributing factors that triggered the alert, which factors can be quickly altered to prevent the ICU transfer. While interpretable machine learning has been extensively studied for years, challenges remain as among …

Go to article

Genomic Contributors To Individual Differences In Reward-Related Neural Activity, Lindsay Jane Michalski Dec 2019

Genomic Contributors To Individual Differences In Reward-Related Neural Activity, Lindsay Jane Michalski

Arts & Sciences Electronic Theses and Dissertations

Aberrant reward-related behavior, including impulsive and risk-taking behaviors, is a common feature of externalizing psychopathology (e.g., attention deficit hyperactivity disorder, antisocial personality disorder, and substance-use disorders). Through imaging studies, these behaviors have been linked to dysregulated reactivity within a diffuse reward-related corticostriatal neural network, including the striatum, frontal regions (namely orbital, ventromedial, and dorsolateral cortices), the insula, and the hippocampus. Because variability in risk-taking behavior and related psychopathology is moderately-to-largely heritable (i.e., with estimates ranging from 40 – 80%), a genetically-informed approach is well-positioned to provide valuable insight into the etiology of reward-related neural and behavioral phenotypes that characterize externalizing …

Go to article

Activation And Regulation Of The Alkbh3-Ascc Alkylation Repair Pathway, Josh Brickner Dec 2019

Activation And Regulation Of The Alkbh3-Ascc Alkylation Repair Pathway, Josh Brickner

Arts & Sciences Electronic Theses and Dissertations

DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions. These lesions are sensed by distinct pathways to recruit repair factors specific to type of damage. In particular, the ALKBH family of proteins recognizes and repairs specific alkylated lesions, including 1-methyladenine (m1A) and 3-methylcytosine (m3C). A major outstanding question in the field is how the AlkB homologue ALKBH3 and its associated protein partners are recruited to sites of alkylation damage and how this repair activity is regulated. Understanding the upstream signaling events that mediate recognition and repair of DNA alkylation damage is particularly …

Go to article

Phylogenetic And Genomic Characterization Of The Host-Pathogen Arms Race Between Bacterial Pathogens And Gossypium Hirsutum, Anne Zimmerman Phillips Dec 2019

Phylogenetic And Genomic Characterization Of The Host-Pathogen Arms Race Between Bacterial Pathogens And Gossypium Hirsutum, Anne Zimmerman Phillips

Arts & Sciences Electronic Theses and Dissertations

Hosts and pathogens are eternally intertwined in an evolutionary arms race. When a pathogen causes a disease outbreak, scientists must identify resistance strategies that can durably tilt the arms race in favor of the host. This requires a deep understanding of both the genetic and environmental contexts in which the outbreak occurs. In this thesis I investigate the bacterial pathogens Xanthomonas citri pv. malvacearum (Xcm) and Pseudomonas syringae that caused disease outbreaks on Gossypium hirsutum from 2011-2017. I use pathogen genomics and host transcriptomics to develop hypotheses for how these pathogens emerged and how they cause disease. Phylogenetics and virulence …

Go to article

Perceptual Precedence Or Increased Effort?: On The Mechanism Of The Small-Picture-Size Advantage In Category Learning, Toshiya Miyatsu Dec 2019

Perceptual Precedence Or Increased Effort?: On The Mechanism Of The Small-Picture-Size Advantage In Category Learning, Toshiya Miyatsu

Arts & Sciences Electronic Theses and Dissertations

I have previously identified a novel perceptual manipulation that enhances learning of some complex natural categories, and the current dissertation aims to uncover its mechanism. Specifically, learning of categories of tropical fish was enhanced when learned through small pictures (about 2º) compared to large pictures (about 19º). Through analyzing the previous results and extant theories in various domains, I identified two potential mechanisms through which this small-picture-size advantage manifested. The perceptual precedence hypothesis postulates that the processing of local dimensions is prioritized in large pictures and the processing of global dimensions is prioritized in small pictures. Therefore, small picture size …

Go to article

Generation And Utilization Of Diverse Memory B Cells After Flavivirus Challenges, Rachel Wong Dec 2019

Generation And Utilization Of Diverse Memory B Cells After Flavivirus Challenges, Rachel Wong

Arts & Sciences Electronic Theses and Dissertations

Over the course of an effective immune response to an infection, two distinct B cell populations are generated to provide protection against reinfection, long-lived plasma cells (LLPCs) and memory B cells (MBCs). LLPCs and MBCs originate from germinal center (GC) B cells that have undergone B cell receptor (BCR) affinity maturation through iterative rounds of somatic hypermutation, proliferation, and selection. Thus, LLPCs and MBCs can bind to their antigen with higher affinity than their naïve B cell precursors. LLPCs constitutively secrete antibodies and can provide sterilizing immunity that pre-exists subsequent infections. MBCs, on the other hand, are quiescent and provide …

Go to article

Devising A Scalable Synthesis To Probe The G-Protein Cell Receptor Signaling Pathway, Matthew Robert Medcalf Dec 2019

Devising A Scalable Synthesis To Probe The G-Protein Cell Receptor Signaling Pathway, Matthew Robert Medcalf

Arts & Sciences Electronic Theses and Dissertations

The G-protein coupled cell receptor signaling pathway is amongst the largest and most diverse class of cell-surface receptors in the body. Nearly 800 different genes encode for these cell membrane receptors which are responsible for mediating a variety of hormones, neurotransmitters, and sensory stimuli through the activation of intracellular G proteins. To date, roughly 34% of pharmaceuticals on the market target GPCR’s, but despite this fact, there are still many difficulties associated with targeting this family of receptors. The vast number of GPCR’s, disease states resulting from a dysregulation of multiple GPCR signaling pathways, and difficulties crystalizing and purifying the …

Go to article

Sideromycin Pathway Elucidation: Insights Into Salmycin Biosynthesis, Transport Paradigms, And Drug Release, Gerry Sann Macaraeg Rivera Dec 2019

Sideromycin Pathway Elucidation: Insights Into Salmycin Biosynthesis, Transport Paradigms, And Drug Release, Gerry Sann Macaraeg Rivera

Arts & Sciences Electronic Theses and Dissertations

Antibiotic resistance is an increasing threat in today’s society. In order to overcome resistant bacteria, it is necessary to discover new drugs with novel mechanisms of action. This work focuses on the sideromycin pathway, encompassing the biosynthetic production, mechanism of entry and hydrolysis-mediated drug release. Sideromycins are an interesting approach to combat the rise of antibiotic resistance since they provide a different avenue that overcomes problems that arise when entering the cell. The dissertation is separated into distinct sections dealing with the various areas of interest in the sideromycin pathway, particularly for the sideromycin, salmycin, produced by Streptomyces violaceus. The …

Go to article

The Tortured Pre-History Of Urban Blight: African American St. Louis And The Politics Of Public Health, 1877-1940, Taylor Desloge Dec 2019

The Tortured Pre-History Of Urban Blight: African American St. Louis And The Politics Of Public Health, 1877-1940, Taylor Desloge

Arts & Sciences Electronic Theses and Dissertations

This dissertation is a long history of the contested legal and environmental category of blight, especially in its racialized dimensions, in tandem with the African American experience of living in blighted urban spaces and forging a black politics of public health and welfare. Rethinking the conventional view that identifies blight as simply a preoccupation of post-World War II planners, this dissertation relocates its roots in a politics of public health that emerged a hundred years earlier, in the Post-Reconstruction Era, when black migration to the city and the rise of industrial capitalism raised new questions over both the social needs …

Go to article

Cyclotron Resonance In Graphene Heterostructurescyclotron Resonance In Graphene Heterostructures, Billy Jordan Russell Dec 2019

Cyclotron Resonance In Graphene Heterostructurescyclotron Resonance In Graphene Heterostructures, Billy Jordan Russell

Arts & Sciences Electronic Theses and Dissertations

We present observations of cyclotron resonance in graphene Van der Waals heterostructure devices. Such devices provide dramatic improvements in sample quality and allow for ad- vanced electronic control, opening windows on previously inaccessible physics. The design and construction of a dedicated system for the measurement of electronic transport and infrared magnetospectroscopy in microscopic samples of atomically thin materials at cryogenic temperatures is presented. In high-mobility encapsulated monolayer graphene, electron- electron interaction effects are unambiguously observed to impact the interband cyclotron resonance as the Landau level filling factor is varied in a quantizing magnetic field. Additionally, a splitting of transitions involving …

Go to article

Investigating Biological Mechanisms Of Radiation Resistance In Advanced Stage Cervical Cancer, Fiona Ruiz Dec 2019

Investigating Biological Mechanisms Of Radiation Resistance In Advanced Stage Cervical Cancer, Fiona Ruiz

Arts & Sciences Electronic Theses and Dissertations

The current standard of care treatment for locally advanced cervical cancer is curative intent pelvic radiation with concurrently administered platinum chemotherapy (CRT). This treatment strategy is effective for many patients, but 33-50% of patients treated with CRT develop disease recurrence. Metastatic and recurrent cervical cancer is an incurable condition, and many of the currently available treatments are associated with significant morbidity and mortality. Identifying these patients upfront is a challenge that clinicians face when developing treatment strategies. Previous studies used to catalog the genomic and transcriptomic landscape of cervical cancer lacked high quality corresponding clinical follow up data for patients, …

Go to article

An Evolving Epigenome That Determines Tissue And Cell Specificity, Renee Louise Sears Dec 2019

An Evolving Epigenome That Determines Tissue And Cell Specificity, Renee Louise Sears

Arts & Sciences Electronic Theses and Dissertations

Understanding the mechanisms driving phenotypic variation is a major goal of biology that unifies classical genetics with the emerging fields of genomics and epigenomics. Human and mouse share over 90% of genes and global tissue-specific patterns of expression are maintained between the species. Thus, it is hypothesized that gene expression is influenced through distinctive regulation among species in order to account for the unmistakable phenotypic divergence. DNA methylation, histone modifications, open chromatin patterns, transcription factor binding, and other epigenetic factors are all associated with shaping, maintaining, and repressing regulatory regions which in turn coordinate gene expression. It is vital to …

Go to article

Three-Dimensional Image Reconstruction In Transcranial Photoacoustic Computed Tomography, Joemini Poudel Dec 2019

Three-Dimensional Image Reconstruction In Transcranial Photoacoustic Computed Tomography, Joemini Poudel

McKelvey School of Engineering Theses & Dissertations

Photoacoustic computed tomography (PACT) is an emerging imaging modality that exploitsoptical contrast and ultrasonic detection principles to form images of the photoacousticallyinduced initial pressure distribution within tissue. The PACT reconstruction problemcorresponds to an inverse source problem in which the initial pressure distribution is recoveredfrom measurements of the radiated pressure wavefield. A major challenge in transcranialPACT brain imaging is compensation for aberrations in the measured data due to the presenceof the skull. Ultrasonic waves undergo absorption, scattering and longitudinal-to-shear wavemode conversion as they propagate through the skull. To properly account for these effects, awave-equation-based inversion method should be employed that can …

Go to article

Transcriptional Regulation Of Adipose Tissue Development By Pexrap And Med19, John Dean Dec 2019

Transcriptional Regulation Of Adipose Tissue Development By Pexrap And Med19, John Dean

Arts & Sciences Electronic Theses and Dissertations

Targeting adipose tissue function to decrease adiposity and improve insulin sensitivity could treat obesity and diabetes. How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat (BAT and WAT), as well as the browning of white fat, remains unclear. Our previous studies suggest that PexRAP, a peroxisomal lipid synthetic enzyme, regulates PPARγ signaling and white adipogenesis.Here, we show that PexRAP is an inhibitor of brown adipocyte gene expression. PexRAP inactivation promoted adipocyte browning, increased energy expenditure, and decreased adiposity. Identification of PexRAP-interacting proteins suggests that PexRAP function extends beyond its …

Go to article

A Noncanonical Function Of The Telomerase Rna Component In Human Embryonic Stem Cells, Kirsten Ann Brenner Dec 2019

A Noncanonical Function Of The Telomerase Rna Component In Human Embryonic Stem Cells, Kirsten Ann Brenner

Arts & Sciences Electronic Theses and Dissertations

Telomeres are stretches of TTAGGG nucleotide repeats located at the ends of linear chromosomes that shorten with progressive cell division and prevent genomic instability at the cost of limiting a cell’s capacity to proliferate. This limitation can be overcome by telomerase, a ribonucleoprotein complex that elongates telomeres via reverse-transcription of the template telomerase RNA component (TERC). Recent studies have reported potential functions of TERC outside of its role in telomere maintenance. These noncanonical functions of TERC are however poorly defined, and the molecular mechanisms and biological relevance behind such functions remain elusive. Here, we generated conditional TERC knock-out human embryonic …

Go to article

Wheelchair Propulsion For Everyday Manual Wheelchair Users: Repetition Training And Machine Learning-Based Monitoring, Pin-Wei Chen Dec 2019

Wheelchair Propulsion For Everyday Manual Wheelchair Users: Repetition Training And Machine Learning-Based Monitoring, Pin-Wei Chen

Arts & Sciences Electronic Theses and Dissertations

Upper limb pain and injuries are prevalent among manual wheelchair users and can restrict their participation and daily activities. Due to the high repetition and force in wheelchair propulsion, chronic wheelchair propulsion has been linked to the risk of upper limb pain and injury. Prevention of upper limb pain and injury is a high priority in wheelchair-related research. Decades of research in wheelchair propulsion biomechanics have led to clinical practice guidelines (CPG). Unfortunately, a decade after the publication of the CPG, CPG-recommended propulsion is still uncommon. Hence, for the first aim, a randomized controlled trial pilot study with two groups …

Go to article

Anion Exchange And Bipolar Membranes For Electrochemical Energy Conversion And Storage, Zhongyang Wang Dec 2019

Anion Exchange And Bipolar Membranes For Electrochemical Energy Conversion And Storage, Zhongyang Wang

McKelvey School of Engineering Theses & Dissertations

Anion exchange and bipolar membrane fuel cells generate electrical energy directly from chemical fuels and have attracted considerable interests as alternate power sources for large market applications, such as transportation (hydrogen fuel cells) and unmanned vehicles (sodium borohydride fuel cells). Anion exchange membrane (AEM), generally composed of a polymer with covalently tethered ionic groups, is the central component of the fuel cell serving as the electrolyte, conducting hydroxide ions from cathode to anode, where fast ionic conduction is directly related to power output. However, AEMs currently used in fuel cells (H2 fuel cells and sodium borohydride fuel cells) exhibit ion …

Go to article

Contemporary Problems In Aerosol Aggregation And Gelation, Pai Liu Dec 2019

Contemporary Problems In Aerosol Aggregation And Gelation, Pai Liu

McKelvey School of Engineering Theses & Dissertations

Aggregation of nanoparticles in aerosols is a fundamental phenomenon with important implications to diverse fields ranging from material synthesis to pollutant control. The past few decades have witnessed extensive research on investigating the structure and growth mechanism of aerosol aggregates with sizes spanning across several orders of magnitude. This dissertation focuses on some contemporary problems that remain unaddressed in this topical area. Aerosol aggregates in sub-micron regimes, which are formed via the irreversible collision and aggregation of solid nanoparticle monomers, are fractal-like in their morphology. A mathematical description of this seemingly random structure dates to the seminal works by Forest …

Go to article

Crip Time In Fin-De-Siècle Spain: Disability, Degeneration, And Eugenics, Erika Rodriguez Dec 2019

Crip Time In Fin-De-Siècle Spain: Disability, Degeneration, And Eugenics, Erika Rodriguez

Arts & Sciences Electronic Theses and Dissertations

A period of intense nation-building, the late nineteenth century was marked by the search for medical and legal solutions to the increasing number of bodies that did not align with culturally constructed expectations of productivity and reproduction in Spanish modernity. Authors of this time used representations of disability to engage in urgent political questions about population control and the rights of individuals in the face of increasing medical intervention. In carrying out this analysis, I raise the question of how representations of disability created a space to reconfigure the social values that determined what lives matter. Focusing on canonical realist …

Go to article

Rhodococcus Opacus Pd630 Genetic Tool Development To Enable The Conversion Of Biomass, Drew Michael Delorenzo Dec 2019

Rhodococcus Opacus Pd630 Genetic Tool Development To Enable The Conversion Of Biomass, Drew Michael Delorenzo

McKelvey School of Engineering Theses & Dissertations

The discovery of fossil fuels facilitated a new era in human history and allowed many firsts, such as the mass production of goods, the ability to travel and communicate long distances, the formation of population dense cities, and unprecedented improvements in quality of life. Alternative sources of energy and chemicals are needed, however, as hydrocarbon reserves continue to deplete and the effects of burning fossils on the planet become better understood. Lignocellulosic biomass is the most abundant raw material in the world and a viable alternative to petroleum-derived products. The pre-treatment of lignocellulose (e.g., thermocatalytic depolymerization, enzymatic hydrolysis, pyrolysis, etc.) …

Go to article

The Transcription Factor Bhlhe40 Regulates Tissue-Resident Macrophages And Type 2 Immunity, Nicholas N. Jarjour Dec 2019

The Transcription Factor Bhlhe40 Regulates Tissue-Resident Macrophages And Type 2 Immunity, Nicholas N. Jarjour

Arts & Sciences Electronic Theses and Dissertations

Transcriptional control of gene expression is essential for life, tailoring protein production to development and environment to maintain organismal homeostasis. A limited set of proteins termed transcription factors are critical to this process. As our understanding of these central regulators has improved, new aspects of cell and organismal biology have been revealed. Herein, we demonstrate the importance of the transcription factor Bhlhe40 to tissue-resident macrophages, T helper type 2 cells, and type 2 immune responses, revealing novel transcriptional control of macrophages and unexpected cytokine regulation of helminth infection. We find that Bhlhe40 is cell-intrinsically required for normal proliferation of large …

Go to article

Next Last