Digital Commons Network^™

Functional Monitoring For Run-Time Assurance Of A Real-Time Cyber Physical System, Matthew W. Gelber

Theses and Dissertations

As cyber-physical systems (CPS) become more integrated into everyday life, the security of these systems must also be considered during their development due to their ever-increasing importance. With the growth of physical components in the system, more autonomous control requirements, and increased dependence on proper functionality, verifying system safety and correct operation becomes increasingly difficult. CPS have become more complex through the combination of additional hardware and the resulting interconnected software in many layers, each requiring unique security solutions. One example of such a safety-critical CPS embedded system is the Flight Control System (FCS) of an Unmanned Aerial System (UAS). …

Adaptive Multi-Label Classification On Drifting Data Streams, Martha Roseberry

Theses and Dissertations

Drifting data streams and multi-label data are both challenging problems. When multi-label data arrives as a stream, the challenges of both problems must be addressed along with additional challenges unique to the combined problem. Algorithms must be fast and flexible, able to match both the speed and evolving nature of the stream. We propose four methods for learning from multi-label drifting data streams. First, a multi-label k Nearest Neighbors with Self Adjusting Memory (ML-SAM-kNN) exploits short- and long-term memories to predict the current and evolving states of the data stream. Second, a punitive k nearest neighbors algorithm with a self-adjusting …

Essays On The Impacts Of Macra 2015 And Market Dynamics On Quality, Billing, And Fraud In The U.S. Healthcare System, Mahmoud Manouchehri Amoli

Theses and Dissertations

This thesis presents a comprehensive examination of the impacts of the Medicare Access and CHIP Reauthorization Act of 2015 (MACRA) and market dynamics on the quality, billing practices, and incidence of fraud within the U.S. healthcare system. It is a compilation of three essays that each delves into a specific facet of the healthcare landscape altered by MACRA's introduction and the evolving market conditions.

Chapter 2 analyzes how MACRA has transformed Medicare Part B physicians' practices by introducing the Merit-Based Incentive Payment System (MIPS) and Advanced Alternative Payment Models (APMs). The study provides empirical evidence on the shift in billing …

Variability In Perceptions Of Complementary Health Approaches Among Graduate Student Trainees, Delaney C. Bilodeau

Theses and Dissertations

Complementary Health Approaches (CHAs) encompass a diverse range of practices which are often used both independently and alongside conventional medical treatments. Understanding how graduate students training in different fields perceive CHAs is important because these professional trainees will go on to occupy roles as healthcare practitioners, researchers, policy makers, and consumers. This study used sequential rank agreement methods (Ekstrøm, Gerds, & Jensen, 2019) to investigate variations in perceptions of CHAs in a sample of graduate students (N = 416) from 140 possible training programs. Ratings of CHA familiarity, perceptions of CHA legitimacy, and willingness to recommend CHAs were compared …

Refashioning Style From The Outside-In: A Pakistani Diasporic Response, Sidra Sohail Khawaja

Theses and Dissertations

Pakistan’s traditionalists and modernists hold opposing political, religious, social and nationalist views creating a constant tension within the culture. This tension creates a fashion industry with two extremes, one side reflecting traditional influences and the other reflecting western trends. I address the tension by analysing the craft and context of traditional Pakistani men’s clothing and incorporating traditional construction techniques into garments that reflect aspects of both points of view. In a series of five looks, I extract from influences like Persian, North Indian, Afghani, Colonial and Neo-Colonial, to generate hybridized garments that offer a new perspective, blending traditional elements with …

Exploring Polyamorous Relationship Experiences Of Lesbian, Gay, Bisexual, And Pansexual Individuals, Jiale Man

Theses and Dissertations

Polyamory is a type of relationship under the consensual non-monogamy relationship umbrella that assumes the possibility, validity, and worthwhileness of maintaining romantic, sexual, and intimate relationships with multiple people simultaneously. In Western society, the prevalence and domination of mononormativity have led to the marginalization of relationships alternative to monogamy (i.e., polyamory). As a result, individuals in polyamorous relationships continue to experience bias, stigma, and discrimination at varying levels. With a rise in public interest in CNM in the past two decades, scientists and researchers have slowly started to examine various topics related to CNM, including its prevalence, public attitudes toward …

Practice Elements Delivered By Teachers To Support Children Who Display Challenging Behaviors In Business-As-Usual Early Childhood Settings, Navneet Kaur

Theses and Dissertations

Approximately 15-25% of children ages 3 to 5 years in early childhood settings display chronic challenging behaviors that increase their risk for developing an emotional and behavioral disorder. The early onset of emotional and behavioral disorders has long-term negative implications for these children. Therefore, it is vital to address these problems early on. One approach is through teacher-delivered practices (i.e., specific strategies, such as praise) and programs (i.e., manualized interventions that contain a collection of practices) in the classroom. Some practices and programs have shown positive outcomes for children. However, when practices and programs do not outperform business-as-usual group (BAU), …

How Teacher-Student Relationships Shape Student Engagement And Interest In Science, Destini N. Braxton

Theses and Dissertations

The current research on emotional engagement and teacher-student relationship is abundant and acknowledges education as an environment that thrives on social interactions and causes a variety of emotions to be present in the classroom. However, research on the relationship between Black and Latinx students’ teacher-student relationships and students’ emotional engagement and interest in science in urban middle school science classrooms remains scarce. Unfortunately, Black and Latinx students often experience a) mixed social interactions with their teachers, b) a lack of relatability to science instruction, and c) a combination of positive and negative emotions during science instruction and activities. This phenomenological, …

Factors Associated With College Students' Intention To Use Telehealth For Primary Care, Conor Duffy

Theses and Dissertations

College students are less likely than the general population to have a regular primary care provider and engage in routine health visits. Recent research provides evidence that telehealth is a convenient alternative to in-person primary care and that college students are comfortable using this technology, suggesting that telehealth has the potential to mitigate this disparity. However, little research has examined which factors are associated with college students’ intention to use telehealth and attitudes toward telehealth specifically in the primary care context. The overarching goal of this study was to address this gap in the literature and identify factors associated with …

Improving The Flexibility And Robustness Of Machine Tending Mobile Robots, Richard Ethan Hollingsworth

Theses and Dissertations

While traditional manufacturing production cells consist of a fixed base robot repetitively performing tasks, the Industry 5.0 flexible manufacturing cell (FMC) aims to bring Autonomous Industrial Mobile Manipulators (AIMMs) to the factory floor. Composed of a wheeled base and a robot arm, these collaborative robots (cobots) operate alongside people while autonomously performing tasks at different workstations. AIMMs have been tested in real production systems, but the development of the control algorithms necessary for automating a robot that is a combination of two cobots remains an open challenge before the large scale adoption of this technology occurs in industry. Currently popular …

Code Beats - Teaching Computer Programming Coding Via Hip Hop Beats, Douglas Lusa Krug

Theses and Dissertations

Computer programming is a crucial skill for future professionals, not only those working as computer programmers but most modern workers. To train the next generation, society has created many initiatives to introduce computer programming to young students. These initiatives range from classes in a formal academic setting to informal, extracurricular sessions in after-school and summer camps. Even with the increasing offer of these initiatives to expand the opportunities to learn computer programming, the interest in computer programming remains low, especially among populations underrepresented in computing. This lack of interest could be impacted by stereotypical views of computer programming as tedious …

A Sustainable Ultrafiltration Of Sub-20 Nm Nanoparticles In Water And Isopropanol: Experiments, Theory And Machine Learning, Jie Mcatee

Theses and Dissertations

This research focused on ultrafiltration (UF) for particles down to 2 nm against membranes with larger pore size in water and IPA, which has the potential to save up to 90% of energy. This study developed electrospray (ES) - scanning mobility particle sizer (SMPS) method to fast and effective measure retention efficiencies for small particles (ZnS, Au and PSL) on polytetrafluoroethylene (PTFE), polyvinylidene fluoride (PVDF) and polycarbonate (PCTE) in different liquids. Theoretical models that could quantitatively explain the experimental results for small particles in medium-polarity organic solvents were also developed. Results showed that the highest efficiency was up to ~80% …

Driven By Personality: Exploring The Relationship Between Custom Cars And Self-Expression, Tharwa Dalansi

Theses and Dissertations

Custom Car Culture (CCC) is a form of creativity that emerges from personal identities and passions. It involves the restoration, modification and personal adornment of commercially manufactured cars. This process creates a journey, where the enthusiast goes through multiple phases of self-reflection. But due to a lack of local resources, Qatar-based CCC enthusiasts often have to send their cars abroad to Dubai or Japan in order to customize them, relinquishing creative control in the process.

In response to these challenges, based on observations and interviews conducted among actual CCC enthusiasts, I develop a platform for engagement between these enthusiasts and …

Model Based Systems Engineering Approaches To Chemicals And Materials Manufacturing, Quang Le

Theses and Dissertations

Model-based systems engineering (MBSE) is part of a long-term trend toward model-centric approaches adopted by many engineering disciplines. This work establishes the need for an MBSE approach by reviewing the importance, complexity, and vulnerability of the U.S. chemical supply chains. The origins, work processes, modeling approaches, and supporting tools of the systems engineering discipline (SE) are discussed, along with the limitations of the current Process Systems Engineering (PSE) framework. The case is made for MBSE as a more generalizable and robust approach. Systems modeling strategies for MBSE are introduced, as well as a novel MBSE method that supports the automation …

一To二To三, Yameng Wang

Theses and Dissertations

This work relates to an animated film focusing on iteration, simulacrum, and artificial intelligence. It is based on the traditional Tao concept: “One life two, two beget three, three beget all things.”

A Learning Health System For Radiation Oncology, Rishabh Kapoor

Theses and Dissertations

The proposed research aims to address the challenges faced by clinical data science researchers in radiation oncology accessing, integrating, and analyzing heterogeneous data from various sources. The research presents a scalable intelligent infrastructure, called the Health Information Gateway and Exchange (HINGE), which captures and structures data from multiple sources into a knowledge base with semantically interlinked entities. This infrastructure enables researchers to mine novel associations and gather relevant knowledge for personalized clinical outcomes.

The dissertation discusses the design framework and implementation of HINGE, which abstracts structured data from treatment planning systems, treatment management systems, and electronic health records. It utilizes …

The Effect Of Mild Traumatic Brain Injury On Perineuronal Nets Surrounding Neocortical Parvalbumin Interneurons, Olivia Lowman

Theses and Dissertations

Mild traumatic brain injury (mTBI) is an extremely common affliction with an estimated 42 million people being affected by it worldwide each year. It can lead to a range of long-term chronic issues and the underlying pathology is not well understood. Several previous studies have shown that parvalbumin inhibitory interneurons (PV+) are injured during TBI, therefore altering the excitatory to inhibitory ratio in neural networks which can lead to several neurodegenerative disorders such as epilepsy. Perineuronal nets (PNNs) are an extracellular matrix element that preferentially surround PV+ neurons in the neocortex and are recently thought to have important roles in …

Protacs – A Novel And Rapidly Developing Field Of Targeted Protein Degradation, Hannah R. Gatley

Theses and Dissertations

There is a continued need for new technology and strategies for tackling cancer and other diseases, and within the current century a novel therapeutic strategy has emerged in the realm of targeted protein degradation called Proteolysis-Targeting Chimeras (PROTACs). This technology specifically targets and degrades disease-causing proteins via the ubiquitin-proteasome system, and has seen an explosion of research and intrigue in both academia and industry over the past two decades. The diversity of PROTAC classes based on the E3 ligase recruiting ligand and the target protein allows for a universal molecular structure that can be customized for a specific target and …

Religiously Responsive Pedagogy In Christian Schools: A Qualitative Exploration Of Faculty Perceptions Of Faith Integration, Andrea R. Woodard

Theses and Dissertations

This qualitative study introduced a theoretical framework of Religiously Responsive Pedagogy (RRP) and explored the ways in which RRP is enacted in Christian schools, along with the barriers and supports that may exist for effective RRP within those schools. The study investigated PK-12 faculty perceptions of faith integration, responsiveness to students, and school support in order to develop this new framework. Twelve teachers participated in a semi-structured interview via Zoom, which included four scenarios to probe teacher perspectives on RRP. The data was coded recursively using Boeije’s (2002) constant-comparative method.

The primary research questions addressed were:

• How do teachers at …

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Combining Novel Direction Modulated Brachytherapy Tandem-And-Ovoids Applicators For Treatment Planning Of Multi-Institutional Cervical Cancer Cases: Removing Needles In Intracavitary-Interstitial Techniques, Sharmin Alam

Theses and Dissertations

Lack of standard guidelines for optimal needle insertion during high-dose-rate (HDR) intracavitary-interstitial (IC-IS) brachytherapy of the cervix means a sophisticated and technical skillset of inserting needles next to IC applicators must be developed to enhance plan quality. This study sought to evaluate the performance of two separate direction modulated brachytherapy (DMBT) tandem applicators used in conjunction with one set of novel DMBT ovoids, to effectively obviate the need for IS needles.

A cohort of 32 retrospective clinical HDR brachytherapy plans was re-planned with Varian’s BrachyVision^® treatment planning system, using VEGO^® inverse optimization algorithm, with dose heterogeneity accounted for …

Intersect- On The Corner Of Princess Anne And William, Madison M. Goff

Theses and Dissertations

After a worldwide pandemic, perspectives towards personal space and private quarters have shifted. Social distancing procedures during COVID-19 altered the use of space, even after vaccinations have been administered. After limits on large gatherings and keeping 6 feet away from each other, what is the expectation that people hold now when in public?

Research will include interviewing the intended user groups (students and travelers), designers who are familiar with hospitality and hostel design, and hospitality professionals. The perspective on private and public space has shifted after the pandemic, so a survey will target hostel age groups that could help understand …

Unraveling The Consequence Of Adult Onset Sulfatide Depletion: Its Implications In Myelin And Axonal Heath In The Context Of Neurodegenerative Disease, Elizabeth Dustin

Theses and Dissertations

Multiple Sclerosis is an immune mediated disease of the CNS. MS is diagnosed through detection of demyelinated regions. However, recent studies demonstrate that Normal Appearing White Matter (NAWM) contains substantial pathology. One such pathology observed in the NAWM is the reduction of sulfatide. The proper stoichiometry of lipids in myelin acts to maintain rapid conduction velocity, provide trophic support to the neuron, and protect the axon from degeneration. We previously characterized a mouse lacking sulfatide’s synthesizing enzyme, CST through constitutive gene disruption and demonstrate that sulfide is required for proper stability of the myelin sheath. However, since MS is typically …

Understanding The Role Of A Regional Magnet School In Creative Identity Development Of Ethnically And Culturally Diverse Adolescents: A Case Study, Preeti Kamat

Theses and Dissertations

The purpose of this dissertation exploratory case study was to examine the creativity-supportive practices at an innovative regional magnet school shaping Ethnically & Culturally Diverse (ECD) students’ creative identity development as perceived by different stakeholders including ECD students enrolled in the first three cohorts, teachers, and school administrators of RichTech Regional Magnet High School [RRMHS] (pseudonym). This single qualitative case study employed a small component of a quantitative survey, the results of which guided in part the design of interview protocols and sampling procedures for recruiting qualitative participants. Using a pragmatic research lens, I obtained and analyzed the diverse qualitative …

Salinization Impacts On Heterotrophic Respiration, Ecosystem Respiration, And Plant Productivity In Tidal Freshwater Marshes, Kelsie J. Moses

Theses and Dissertations

Tidal freshwater marshes have preserved substantial stocks of soil carbon, which represents carbon dioxide that is no longer in the atmosphere. There is conflicting evidence in the literature about how disturbances such as sea level rise and associated wetland salinization impact the accumulation and long-term stability of this stored carbon. The goal of this experiment was to quantify how salinization impacts total ecosystem respiration and its component parts, autotrophic and heterotrophic respiration. This was a microcosm experiment using a C4 plant (Spartina cynosuroides) grown in soil derived from C3 plant matter and exposed to different salinities (0 to …

The Impact Of A Parent-Only Pediatric Obesity Intervention Program On Quality Of Life In Racially Diverse Children, Taylor Vashro

Theses and Dissertations

Pediatric obesity has been associated with significant decrements in pediatric quality of life (QOL) comparable with severe pediatric diseases such as cancer. Parenting interventions have yielded health benefits for children with obesity; however, few studies have investigated the impact of parent-focused interventions on QOL in children with overweight and obesity. This study investigated the impact of a 6-week intensive parenting intervention program on the QOL of 5-12 year old, predominantly Black children with overweight and obesity. Parents were randomized into either the parenting intervention (NOURISH+) or a control group, and QOL, as well as variables related to child and parenting …

Using Superatomic Clusters And Charge Transfer Ligands To Control Electronic Characteristics Of Phosphorene Nanoribbons And Phosphorene Monolayer, Ryan Lambert

Theses and Dissertations

Phosphorene is a two-dimensional electron poor p-type semiconductor with high carrier mobility and great promise for applications in electronics and optoelectronics. As the main theme in this dissertation, the following work represents different investigations of various electronic properties associated with phosphorene. Most notable are the findings on charge transfer doping with metal-chalcogenide superatoms which displays novel control of the two most important properties of a semiconductor – the band gap energy and the nature of carriers. By tuning the width of the gap and p-/n-type character of conduction, we gain control over a material’s capacity to play a certain role …

Dental Treatment Planning: Decisions With Interdisciplinary Cases, William W. Porzio

Theses and Dissertations

Purpose: To explore the variance in treatment planning options with interdisciplinary cases that involve a combination of endodontic, periodontic, and prosthodontic factors.

Methods: A REDCap survey was emailed to Virginia based American Academy of Periodontology (AAP) members, American College of Prosthodontists (ACP) members, and periodontal residents to assessing various treatment planning options for six interdisciplinary cases.

Results: A total of 56 individuals responded to the survey; 10 periodontal residents, 35 practicing periodontists, 11 practicing prosthodontists. Response rate was not able to be evaluated based on the fact that third-party organizations were used to disseminate the survey in …

The Wound Healing And Antibacterial Properties Of Mesenchymal Stromal Cell Extracellular Matrix Nanoparticles, Emily N. Wandling

Theses and Dissertations

Treatments for acute respiratory distress syndrome (ARDS) are still unavailable and the prevalence of the disease has only increased due to the Covid-19 pandemic. Mechanical ventilation regiments are still utilized to support declining lung function, but they also contribute to lung damage and increase the risk of bacterial infection. The anti-inflammatory and pro-regenerative abilities of mesenchymal stromal cells (MSCs) have shown to be a promising therapy for ARDS. We propose to utilize the regenerative effects of MSC secretome and the extracellular matrix (ECM) into a nanoparticle. Our mouse MSC (MMSC) ECM nanoparticles were characterized using size, zeta-potential, and mass spectrometry …

Waiting To Exhale, Abigail H. Ogle

Theses and Dissertations

We breathe as a measure of time, it keeps us alive, and fabricates the pattern of our lives. We are punctuated by “snarls,” “glitches,” or moments of irregularity – of trying to catch one's breath, having it taken away, or gasping for it. It is the punctuation of sighs, huffs, sniffs, scoffs, screams, and deep intakes that appear as glitches in the breathing system.

In our daily rhythm of breathing, the presence of the glitch, defined as potentiality, can create space for something unexpected or new to arise. Using the wind from fans and approximately 1,260 square feet of silk, …

Characterization And Investigation Of Cold Atmospheric Plasma And Its Effects On Cancer Cell Biology, Thomas M. Ritrosky

Theses and Dissertations

Modern cancer treatment uses radiation therapy in over 50% of patient cases. It is an e↵ective way of treating tumors because the mechanisms of cell killing are well known through the damage that ionizing radiation does to DNA. The amount of radiation can be tracked through measuring the dose of the clinical photon or electron beam used. However, there are limitations in the usage of radiation therapy, for example, a tumor can create hypoxic areas that become radioresistant leading to complete ine↵ectiveness of further radiation treatment. This project looks into the application of cold atmospheric plasma as an adjuvant therapy …