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The Role Of Medical Comorbidities On The Risk For Severe Dementia, Institutionalization, And Death In Alzheimer's Disease: A Population Study In Cache County, Utah, Mac J. Gilbert
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Alzheimer’s disease is a progressive disease that impairs cognitive and functional abilities. Without a cure, it is estimated there will be 81 million cases of Alzheimer’s disease by 2040. Life for the individual with Alzheimer’s disease, and their family, changes drastically when the affected individual experiences significant problems with memory, thinking, and ability to complete daily tasks. Some become so debilitated that they need to be placed in a nursing home for supportive care. Until a cure is discovered, it will be important to identify what can be done to help those with Alzheimer’s disease minimize time spent experiencing severe …
Does Non-Steroidal Anti-Inflammatory Drug (Nsaid) Use Affect Dementia Progression And Survival Rates In Alzheimer's Disease? The Cache County Study, Trevor R. Buckley
Does Non-Steroidal Anti-Inflammatory Drug (Nsaid) Use Affect Dementia Progression And Survival Rates In Alzheimer's Disease? The Cache County Study, Trevor R. Buckley
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Alzheimer's disease (AD) has multiple factors that contribute to the disease process. Among these is a state of chronic inflammation that is endured by the brain during the aging process. The use of non-steroidal anti-inflammatory drugs (NSAIDs) decreases the amount of neuroinflammation sustained by the brain, and greater levels of NSAID use have been demonstrated to be associated with decreased probability of developing AD. This study looked at whether greater rates of NSAID use were also associated with decreased rates of cognitive and funtional decline and survival in a population-based sample of persons with AD. Linear mixed models failed to …