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Evaluating The Computational Efficiency Of Xfbat And Fbat For Family Based Studies, Yanwei Ouyang

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Family-based study designs are often employed when investigating the genetic causes of complex disease. While the transmission disequilibrium test (TDT) and its extensions were developed to use family data for assessing linkage between a known genetic marker and a disease-causing gene, the so-called FBAT approach proposed by Rabinowitz and Laird (2000) effectively subsumes these family-based procedures as special cases. FBAT is fully conditional, but its implementation in the freely available FBAT software package uses a large-sample distributional approximation to compute p-values. The exact distribution for FBAT can be enumerated, but doing so explicitly is computationally intensive, particularly for relatively larger …