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Are Antibiotics, Other Than Roxithromycin, An Effective Way To Manage Joint Pain In Rheumatoid Arthritis?, Kelly A. Hoffman

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine “Are antibiotics, other than roxithromycin, an effective way to manage joint pain in rheumatoid arthritis?”

STUDY DESIGN: Review of three double-blind, randomized-controlled studies published in English between 2001-2007.

DATA SOURCES: Three randomized controlled trials published between 2001 and 2007 were found using PubMed/MEDLINE and Cochrane databases.

OUTCOMES MEASURED: Clinical outcome for all three studies used American College of Rheumatology (ACR) criteria, which assesses joints for swelling and tenderness.

RESULTS: In the Odell et al.1 study, at 24 months 28 participants did meet the ACR50 …

Is Oral Isotretinoin More Effective Than Antibiotics In The Treatment Of Severe Acne In Adults?, Eric Thomas

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not the use of oral isotretinoin is more effective than oral antibiotics in the treatment of severe acne.

Study Design: Review of all English language primary studies published after year 2000.

Data Sources: Three randomized control trials all found using PubMed. Outcomes Measured: Total number and percentage change in total acne lesions from baseline at various intervals.

Results: A randomized control trial (RCT) by Gollnick et al. (2001) found that oral isotretinoin was more effective than combination therapy involving minocycline in treating severe …