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Overexpression Of Hdac1 Induces Functional Β-Cell Mass, Carrie Draney

Theses and Dissertations

Type 2 diabetes is a metabolic disorder that results in β-cell dysfunction and ultimate destruction, and leads to impaired glucose homeostasis. High rates of proliferation and differentiation of pancreatic β-cells occurs mostly during neonatal development. However, research shows these mechanisms remain intact as β-cell proliferation has been observed during pregnancy and obesity. We have shown that overexpression of the β-cell transcription factor Nkx6.1 is sufficient to induce β-cell proliferation. Exploration of the transcriptional targets of Nkx6.1 has identified histone deacetylase 1 (HDAC1) as a down-stream target of Nkx6.1. Here we demonstrate that HDAC1 overexpression is sufficient to induce β-cell proliferation, …

Long-Term Treatment With Insulin And Retinoic Acid Increased Glucose Usage In L6 Muscle Cells Via Glycogenesis, Matthew Ray Goff

Doctoral Dissertations

Skeletal muscle glucose metabolism can affect whole body glucose homeostasis significantly. Vitamin A (VA) plays a role in a number of physiological functions including glucose metabolism. However, its role in skeletal muscle glucose metabolism has not been well established. Insulin controls glucose metabolism in the skeletal muscle via the regulations of glucose uptake, glycogenesis, and glycolysis. We hypothesize that insulin and VA signaling pathways may converge to regulate glucose metabolism in skeletal muscle. Here, the effects of retinoic acid (RA) alone and in combination with insulin on glucose utilization in rat L6 muscle cells were studied. L6 cells were treated …

The Effect Of Moderate Consumption Of Non-Nutritive Sweeteners On Glucose Tolerance And Body Composition In Rats, Ashley Power Tovar

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Effect of Moderate Consumption Of Non-Nutritive Sweeteners On Glucose Tolerance And Body Composition In Rats

by Ashley Tovar

John C. Young, Ph.D., Examination Committee Chair Professor, Kinesiology and Nutrition Sciences University of Nevada, Las Vegas

Introduction: A comorbidity often seen with obesity is the development of impaired glucose tolerance. Abnormalities in the ability to metabolize glucose can lead to increased risk of developing pre-diabetes and if continued, diabetes mellitus type 2. To combat the effects of excess energy intake on obesity and glucose intolerance, low- energy and non-nutritive sweeteners have been introduced as a replacement for traditional sucrose and …

Using The Des-28 Tool To Determine The Relationship Among Diabetes Self-Empowerment, Diet Quality, And Glycemic Control In A Southeastern United States African American Population, Makala Katuscak Smith

Graduate Theses

No abstract provided.