Digital Commons Network^™

Making Research Real: Is Action Research A Suitable Methodology For Medical Information Security Investigations?, Patricia A. Williams

Australian Information Security Management Conference

In the medical field, information security is an important yet vastly underrated issue. Research into the protection of sensitive medical data is often technically focused and does not address information systems and behavioural aspects integral to effective information security implementation. Current information security policy and guidelines are strategically oriented which, whilst relevant to large organisations, are less supportive to smaller enterprises such as primary care practices. Further, the conservative nature of the medical profession has been shown to hinder investigation into information technology use and management, making effective improvement based on research problematical. It is an environment which relies greatly …

Policy Analysis For Natural Hazards: Some Cautionary Lessons From Environmental Policy Analysis, Matthew D. Adler

All Faculty Scholarship

How should agencies and legislatures evaluate possible policies to mitigate the impacts of earthquakes, floods, hurricanes and other natural hazards? In particular, should governmental bodies adopt the sorts of policy-analytic and risk assessment techniques that are widely used in the area of environmental hazards (chemical toxins and radiation)? Environmental hazards policy analysis regularly employs proxy tests, in particular tests of technological “feasibility,” rather than focusing on a policy’s impact on well-being. When human welfare does enter the analysis, particular aspects of well-being, such as health and safety, are often given priority over others. “Individual risk” tests and other features of …

Decision-Making About Volitional Impairment In Sexually Violent Predators, Cynthia Calkins Mercado, Brian H. Bornstein, Robert F. Schopp

Department of Psychology: Faculty Publications

The Kansas v. Hendricks (1997) decision, in which the Supreme Court authorized post-sentence civil commitment for certain sex offenders, appeared to be constitutionally legitimized by limiting the class of offenders eligible for this special form of civil commitment to those who are “unable to control” their dangerousness. Nowhere in the available record, however, did the Court elucidate what they meant by this notion of volitional impairment. This study sought to examine factors that legal professionals (n = 43), psychologists (n = 40), and mock jurors (n = 76) deem most relevant to a determination of sex offender volitional impairment. Participants, …

Did Nepa Drown New Orleans? The Levees, The Blame Game, And The Hazards Of Hindsight, Thomas O. Mcgarity, Douglas A. Kysar

Cornell Law Faculty Publications

This Article highlights the hazards of hindsight analysis of the causes of catastrophic events, focusing on theories of why the New Orleans levees failed during Hurricane Katrina in 2005 and particularly on the theory that the levee failures were "caused" by a 1977 National Environmental Policy Act (NEPA) lawsuit that resulted in a temporary injunction against the Army Corps of Engineers' hurricane protection project for New Orleans. The Article provides a detailed historical reconstruction of the decision process that eventuated in the New Orleans storm surge protection system, focusing both on the political and legal factors involved and on the …

Natural Disaster Risks: An Introduction, W. Kip Viscusi

Vanderbilt Law School Faculty Publications

An introduction to a special issue of the Journal of Risk and Uncertainty dealing with the implications of catastrophic events for research on risk and uncertainty. What are the consequences of natural disasters? How do individuals and firms respond to such disasters? How do insurers respond, and how should the government respond? Several of these papers will have a strong normative component as they will suggest what actions individuals, firms, and the government should take in anticipation of natural disasters.

Botulinum Toxin Type A In The Prophylactic Treatment Of Chronic Tension-Type Headache: A Multicentre, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study, Stephen D. Silberstein, H. Göbel, R. Jensen, A. H. Elkind, R. Degryse, J. M.C.M. Walcott, C. Turkel

Department of Neurology Faculty Papers

We studied the safety and efficacy of 0 U, 50 U, 100 U, 150 U (five sites), 86 Usub and 100 Usub (three sites) botulinum toxin type A (BoNTA; BOTOX); Allergan, Inc., Irvine, CA, USA) for the prophylaxis of chronic tension-type headache (CTTH). Three hundred patients (62.3% female; mean age 42.6 years) enrolled. For the primary endpoint, the mean change from baseline in the number of TTH-free days per month, there was no statistically significant difference between placebo and four BoNTA groups, but a significant difference favouring placebo vs. BoNTA 150 was observed (4.5 vs. 2.8 tension headache-free days/month; P …

Integrated Natural Disaster Risk Assessment: The Socio-Economic Dimension Of Earthquake Risk In The Urban Area, Sibel Kalaycioglu, Helga Rittersberger-Tilic, Kezban Celik, Fatime Günes

Geohazards

Understanding and formulation of risk of a natural disaster requires consideration of every aspect of risk, which can be handled by development of integrated approaches. In such integrated approaches, several discipline’s views are incorporated into risk assessment to see the whole picture. Hence, the risk which can be experienced before and / or after a natural disaster should be a common concern for both natural and social disciplines and should be handled through a interdisciplinary approach. A field research was conducted with 1500 households, selected through stratified random sampling, using the database obtained from the Eskisehir Greater Metropolitan Municipality. Interviews …

Lockhart Catchment Appraisal 2005, Susan Murphy-White, P Leoni

Resource management technical reports

The Lockhart Catchment is the largest subcatchment of the Avon River Basin covering just over 3.56 million hectares, including 15 Shires running from Quairading and Bruce Rock in the north to Pingrup and Lake King in the south. This document aims to give the reader a starting point from which to further assess larger scale areas of the catchment for the purpose of planning to reverse and improve land degradation and sustainable farming in Western Australia.

The Legacy Of John Graham: Strait-Jacketing Risk Assessment, Rena I. Steinzor

Faculty Scholarship

No abstract provided.

The Molecular Portraits Of Breast Tumors Are Conserved Acress Microarray Platforms, Zhiyuan Hu, Cheng Fan, Daniel S. Oh, J. S. Marron, Xiaping He, Bahjat F. Qaqish, Chad Livasy, Lisa A. Carey, Evangeline Reynolds, Lynn Dressler, Andrew Nobel, Joel Parker, Matthew G. Ewend, Lynda R. Sawyer, Junyuan Wu, Yudong Liu, Rita Nanda, Maria Tretiakova, Alejandra Ruiz Orrico, Donna Dreher, Juan P. Palazzo, Laurent Perreard, Edward Nelson, Mary Mone, Heidi Hansen, Michael Mullins, John F. Quackenbush, Matthew J. Ellis, Olufunmilayo I. Olopade, Philip S. Bernard, Charles M. Perou

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background

Validation of a novel gene expression signature in independent data sets is a critical step in the development of a clinically useful test for cancer patient risk-stratification. However, validation is often unconvincing because the size of the test set is typically small. To overcome this problem we used publicly available breast cancer gene expression data sets and a novel approach to data fusion, in order to validate a new breast tumor intrinsic list.

Results

A 105-tumor training set containing 26 sample pairs was used to derive a new breast tumor intrinsic gene list. This intrinsic list contained 1300 genes …

Security Risk Assessment: Group Approach To A Consensual Outcome, Ben Beard, David J. Brooks

Australian Information Warfare and Security Conference

AS/NZS4360:2004 suggests that the risk assessment process should not be conducted or information gathered in isolation. This insular method of data collection may lead to inaccurate risk assessment, as stakeholders with vested interests may emphasise their own risks or game the risk assessment process. The study demonstrated how a consensual risk assessment approach may result in a more acceptable risk assessment outcome when compared to individual assessments. The participants were senior managers at a West Australian motel located on the West Coast Highway, Scarborough. The motel consists of four three storey blocks of units, resulting in a total of 75 …

Animal Carcinogenicity Studies: Implications For The Reach System, Andrew Knight, Jarrod Bailey, Jonathan Balcombe

Experimentation Collection

The 2001 European Commission proposal for the Registration, Evaluation and Authorisation of Chemicals (REACH) aims to improve public and environmental health by assessing the toxicity of, and restricting exposure to, potentially toxic chemicals. The greatest benefits are expected to accrue from decreased cancer incidences. Hence the accurate identification of chemical carcinogens must be a top priority for the REACH system. Due to a paucity of human clinical data, the identification of potential human carcinogens has conventionally relied on animal tests. However, our survey of the US Environmental Protection Agency’s (EPA’s) toxic chemicals database revealed that, for a majority of the …

Animal Carcinogenicity Studies: 1. Poor Human Predictivity, Andrew Knight, Jarrod Bailey, Jonathan Balcombe

Experimentation Collection

The regulation of human exposure to potentially carcinogenic chemicals constitutes society’s most important use of animal carcinogenicity data. Environmental contaminants of greatest concern within the USA are listed in the Environmental Protection Agency’s (EPA’s) Integrated Risk Information System (IRIS) chemicals database. However, of the 160 IRIS chemicals lacking even limited human exposure data but possessing animal data that had received a human carcinogenicity assessment by 1 January 2004, we found that in most cases (58.1%; 93/160), the EPA considered animal carcinogenicity data inadequate to support a classification of probable human carcinogen or non-carcinogen. For the 128 chemicals with human or …

Animal Carcinogenicity Studies: 2. Obstacles To Extrapolation Of Data To Humans, Andrew Knight, Jarrod Bailey, Jonathan Balcombe

Experimentation Collection

Due to limited human exposure data, risk classification and the consequent regulation of exposure to potential carcinogens has conventionally relied mainly upon animal tests. However, several investigations have revealed animal carcinogenicity data to be lacking in human predictivity. To investigate the reasons for this, we surveyed 160 chemicals possessing animal but not human exposure data within the US Environmental Protection Agency chemicals database, but which had received human carcinogenicity assessments by 1 January 2004. We discovered the use of a wide variety of species, with rodents predominating, and of a wide variety of routes of administration, and that there were …

Animal Carcinogenicity Studies: 3. Alternatives To The Bioassay, Andrew Knight, Jarrod Bailey, Jonathan Balcombe

Experimentation Collection

Conventional animal carcinogenicity tests take around three years to design, conduct and interpret. Consequently, only a tiny fraction of the thousands of industrial chemicals currently in use have been tested for carcinogenicity. Despite the costs of hundreds of millions of dollars and millions of skilled personnel hours, as well as millions of animal lives, several investigations have revealed that animal carcinogenicity data lack human specificity (i.e. the ability to identify human non-carcinogens), which severely limits the human predictivity of the bioassay. This is due to the scientific inadequacies of many carcinogenicity bioassays, and numerous serious biological obstacles, which render profoundly …

Multicriteria Decision Analysis: A Comprehensive Decision Approach For Management Of Contaminated Sediments, I Linkov, F K. Satterstrom, G Kiker, T P. Seager, T Bridges, K H. Gardener, S H. Rodgers, D A. Belluck, A Meyer

US Army Corps of Engineers

Contaminated sediments and other sites present a difficult challenge for environmental decision makers. They are typically slow to recover or attenuate naturally, may involve multiple regulatory agencies and stakeholder groups, and engender multiple toxicological and ecotoxicological risks. While environmental decision-making strategies over the last several decades have evolved into increasingly more sophisticated, information-intensive, and complex approaches, there remains considerable dissatisfaction among business, industry, and the public with existing management strategies. Consequently, contaminated sediments and materials are the subject of intense technology development, such as beneficial reuse or in situ treatment. However, current decision analysis approaches, such as comparative risk assessment, …

Ecology In A Cost-Benefit Society: The Issues, Valery E. Forbes, Peter Calow

Valery Forbes Publications

Is there a role for ecology in a cost-benefit society? As a prelude to a collection of papers arising from a conference on this theme held at Roskilde University in June 2004, this paper summarizes divergent approaches to public policy decision making. Whether based on strict cost-benefit analysis or wide-ranging discussion, we make the point that decisions need to be informed by an understanding of the causes behind environmental problems and their consequences, through impaired ecosystem services, on the economy. Taking this forward will require forums that bring ecologists, economists, and regulators into active and constructive dialogue.

A Framework For Spatial Risk Assessments: Potential Impacts Of Nonindigenous Invasive Species On Native Species, Craig R. Allen, Alan R, Johnson, Leslie Parris

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

Many populations of wild animals and plants are declining and face increasing threats from habitat fragmentation and loss as well as exposure to stressors ranging from toxicants to diseases to invasive nonindigenous species. We describe and demonstrate a spatially explicit ecological risk assessment that allows for the incorporation of a broad array of information that may influence the distribution of an invasive species, toxicants, or other stressors, and the incorporation of landscape variables that may influence the spread of a species or substances. The first step in our analyses is to develop species models and quantify spatial overlap between stressor …

The Speciation Of Metals In Mammals Influences Their Toxicokinetics And Toxicodynamics And Therefore Human Health Risk Assessment, Robert A. Yokel, Stephen M. Lasley, David C. Dorman

Pharmaceutical Sciences Faculty Publications

Chemical form (i.e., species) can influence metal toxicokinetics and toxicodynamics and should be considered to improve human health risk assessment. Factors that influence metal speciation (and examples) include: (1) carrier-mediated processes for specific metal species (arsenic, chromium, lead and manganese), (2) valence state (arsenic, chromium, manganese and mercury), (3) particle size (lead and manganese), (4) the nature of metal binding ligands (aluminum, arsenic, chromium, lead, and manganese), (5) whether the metal is an organic versus inorganic species (arsenic, lead, and mercury), and (6) biotransformation of metal species (aluminum, arsenic, chromium, lead, manganese and mercury). The influence of speciation on metal …

Cancerous Contradictions: The Mis-Regulation Of Human Carcinogens Based On Animal Data, Andrew Knight, Jarrod Bailey, Jonathan Balcombe

Experimentation Collection

The regulation of human exposures to potential carcinogens constitutes society’s most important use of animal carcinogenicity data. However, for environmental contaminants of greatest U.S. concern, we found that in most cases (58.1%; 93/160) the U.S. Environmental Protection Agency (EPA) considered the animal data inadequate to support a classification of probable human carcinogen or noncarcinogen.

The World Health Organisation’s International Agency for Research on Cancer (IARC) is a leading international authority on carcinogenicity assessments. For chemicals lacking human exposure data (the great majority), IARC classifications of identical chemicals were significantly more conservative than EPA classifications (p

Observational Approach For Urban Landslide Management, Phil Flentje, Robin N. Chowdhury

Faculty of Engineering - Papers (Archive)

The occurrence of landslides in urban hillside areas poses significant challenges for risk management within residential suburbs as well as along road and railway lines. The main focus of this paper is the development of an “observational approach” for landslide risk management and its application within an important landslide study area, the Wollongong Local Government Area, in the state of New South Wales, Australia. Monitoring of subsurface shear movement and pore water pressures at a number of places in the study area during the last decade has already proved very useful in combination with rainfall data from a number of …

Social Dimensions In Rural Land Use Management In The Avon River Basin, B Toric

Resource management technical reports

The aim of the survey, based on responses of 16 farmers in the West Mortlock and Upper Yilgarn catchments in Western Australia was to determine: farmers' beliefs and attitudes towards land use strategies and practices; key community drivers, motivators and other factors in the community which impact on farmer decision-making; perceived control factors that facilitate or impede behaviour and their power; farmers views on land use management on their farm and in the region.

Hillman And Narrogin Zones (Blackwood Zones 8 And 9) : Rapid Catchment Appraisal, Henry Brockman

Resource management technical reports

The aims of this Resource Management Technical Report are to assess the current extent of salinity and other natural resource degradation hazards within the Hillman and Narrogin Zones of Western Australia. These zones cover 409,000 hectares in South West Western Australia, including the towns of Narrogin and Darkan. It also includes benchmarks and sustainability indicators that can be used by landholders and planners to determine the best management options for the area.

Natural Resource Management Issues In The Avon River Basin, Paul Galloway

Resource management technical reports

Analyses the risk of soil, land and water degradation within the Avon River Basin of Western Australia. Information is based on the interpretation of the characteristics of soils and landscapes within the Avon River basin. This report deals with 15 natural resource management issues and describes the extent of each issue, the impacts that each issue will have, management options that can be used to deal with each issue, and the effectiveness of each management option in dealing with the issues.

Ravensthorpe Area Catchment Appraisal 2006, A Massenbauer

Resource management technical reports

The Ravensthorpe area covers 861, 000 hectares. Ninety percent of the study area covered in this report falls within the Ravensthorpe Shire, Western Australia. This document aims to give the reader a starting point from which to further assess larger scale areas of the catchment for the purpose of planning to reverse and improve land degradation and sustainable farming in Western Australia.