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Formation Of Monofunctional Cisplatin-Dna Adducts In Carbonate Buffer, Alexandra Binter, Jerry Goodisman, James C. Dabrowiak
Formation Of Monofunctional Cisplatin-Dna Adducts In Carbonate Buffer, Alexandra Binter, Jerry Goodisman, James C. Dabrowiak
Chemistry - All Scholarship
Carbonate in its various forms is an important component in blood and the cytosol. Since, under conditions that simulate therapy, carbonate reacts with cisplatin to form carbonato complexes, one of which is taken up and/or modified by the cell [C.R. Centerwall, J. Goodisman, D.J. Kerwood, J. Am. Chem. Soc., 127 (2005) 12768–12769], cisplatin-carbonato complexes may be important in the mechanism of action of cisplatin. In this report we study the binding of cisplatin to pBR322 DNA in two different buffers, using gel electrophoresis. In 23.8 mM HEPES, N-(2-hydroxyethyl)-piperazine-N′-2-ethanesulfonic acid, 5 mM NaCl, pH 7.4 buffer, cisplatin produces …
Constancy In Integrated Cisplatin Plasma Concentrations Among Pediatric Patients, Jerry Goodisman, Abdul-Kader Souid
Constancy In Integrated Cisplatin Plasma Concentrations Among Pediatric Patients, Jerry Goodisman, Abdul-Kader Souid
Chemistry - All Scholarship
The authors report on the variability in the integrated quantity of free (unbound) plasma cisplatin (area under curve of plasma concentration versus time, AUC). The AUC was measured in 19 patients receiving cisplatin doses proportional to body surface areas (BSA), 30mg/m2 over 1 hour. The relative standard deviation (RSD, population standard deviation divided by mean value) for the maximum free plasma cisplatin concentration (Cmax, μM) was 0.338; for the half-life (t½, minute), 0.210; and for the AUC (μM minute), 0.320. Thus, BSA-based dosing gave significant variability in the AUC. We attempted to use (weight)a(height)b, seeking values of a and b …