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Osteogenesis Imperfecta. The Position Of Substitution For Glycine By Cysteine In The Triple Helical Domain Of The Pro Alpha 1(I) Chains Of Type I Collagen Determines The Clinical Phenotype., Barbra J. Starman, David Eyre, Harry Charbonneau, Maria Harrylock, Mary Ann Weis, Lester Weiss, John M. Graham Jr., Peter H. Byers

Dartmouth Scholarship

Skin fibroblasts grown from three individuals with osteogenesis imperfecta (OI) each synthesized a population of normal type I collagen molecules and additional molecules that had one or two alpha 1(I) chains that contained a cysteine residue within the triple-helical domain, a region from which cysteine normally is excluded. The patients had very different phenotypes. One patient with OI type I had a population of alpha 1(I) chains in which glycine at position 94 of the triple helix was substituted by cysteine; a patient with OI type III had a population of alpha 1(I) chains in which glycine at position 526 …

G89-989 How To Interpret The New Animal Model For Dairy Sire Evaluation, Jeffrey F. Keown

University of Nebraska-Lincoln Extension: Historical Materials

In question and answer format this NebGuide addresses changes in genetic evaluations of both dairy cows and sores.

Why is the United States Department of Agriculture (USDA) changing the dairy sire and cow evaluation system?

The answer is simple. The Animal Model for genetic evaluations is more accurate than the old Modified Contemporary Comparison Method (M.C.C.). Previously the major limiting factors to implementing the Animal Model were computing costs and memory requirements. With the advent of new Super Computers, the computations are feasible on a national scale.

What is the Animal Model?

The Animal Model simultaneously evaluates cows and sires …