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Resistance To Adenovirally Induced Hyperleptinemia In Rats, Guoxun Chen, Kazunori Koyama, Michio Shimabukuro, May-Yun Wang, Young Lee, Pushpa S. Kalra, Michael J. Dube, Satya P. Kalra, Christopher B. Newgard, Roger H. Unger
Resistance To Adenovirally Induced Hyperleptinemia In Rats, Guoxun Chen, Kazunori Koyama, Michio Shimabukuro, May-Yun Wang, Young Lee, Pushpa S. Kalra, Michael J. Dube, Satya P. Kalra, Christopher B. Newgard, Roger H. Unger
Nutrition Publications and Other Works
Leptin regulates appetite and body weight via hypothalamic targets, but it can act directly on cultured pancreatic islets to regulate their fat metabolism. To obtain in vivo evidence that leptin may act peripherally as well as centrally, we compared the effect of adenovirally induced hyperleptinemia on food intake, body weight, and islet fat content in ventromedial hypothalamic-lesioned (VMHL) rats, shamlesioned (SL) controls, and Zucker Diabetic Fatty (ZDF) rats in which the leptin receptor is mutated. Infusion with recombinant adenovirus containing the rat leptin cDNA increased plasma leptin by z 20 ng/ml in VMHL and ZDF rats but had no effect …
Resistance To Adenovirally Induced Hyperleptinemia In Rats, Guoxun Chen, Kazunori Koyama, Michio Shimabukuro, May-Yun Wang, Young Lee, Pushpa S. Kalra, Michael J. Dube, Satya P. Kalra, Christopher B. Newgard, Roger H. Unger
Resistance To Adenovirally Induced Hyperleptinemia In Rats, Guoxun Chen, Kazunori Koyama, Michio Shimabukuro, May-Yun Wang, Young Lee, Pushpa S. Kalra, Michael J. Dube, Satya P. Kalra, Christopher B. Newgard, Roger H. Unger
Nutrition Publications and Other Works
Leptin regulates appetite and body weight via hypothalamic targets, but it can act directly on cultured pancreatic islets to regulate their fat metabolism. To obtain in vivo evidence that leptin may act peripherally as well as centrally, we compared the effect of adenovirally induced hyperleptinemia on food intake, body weight, and islet fat content in ventromedial hypothalamic-lesioned (VMHL) rats, shamlesioned (SL) controls, and Zucker Diabetic Fatty (ZDF) rats in which the leptin receptor is mutated. Infusion with recombinant adenovirus containing the rat leptin cDNA increased plasma leptin by z 20 ng/ml in VMHL and ZDF rats but had no effect …