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Structure, Transcription And Evolution Of The Alu Family Of Interspersed Repetitive Dna Sequences, James Tilford Elder Jun 1982

Structure, Transcription And Evolution Of The Alu Family Of Interspersed Repetitive Dna Sequences, James Tilford Elder

Yale Medicine Thesis Digital Library

The cloning of DNA fragments derived from the (beta)-like globin gene cluster of normal and (beta)('+)-thalassemic individuals is described. These and other cloned human DNA fragments are employed to define the strucure and transcription of a family of interspersed, repetitive RNA polymerase III transcription units in human DNA. These data allow unequivocal identification of these transcription units with the Alu family of interspersed, repetitive DNA sequences. Comparison of these sequences to those of other primate and rodent interspersed repeats reveals that the primate sequence resembles in many respects a dimer of the rodent sequence. This striking interordinal divergence stands in …


Somatic Cell Genetic And Molecular Analysis Of Dna-Mediated Gene Transfer, Kenneth Michael Huttner May 1982

Somatic Cell Genetic And Molecular Analysis Of Dna-Mediated Gene Transfer, Kenneth Michael Huttner

Yale Medicine Thesis Digital Library

No abstract provided.


Sclerosis-Associated Follicular Center Cell Lymphoma In The Retroperitoneum : The First Clinicopathologicla Study Of A Frequently Encountered Subtype Of Non-Hodgkin's Lymphoma, Michael Ethan Katz Mar 1982

Sclerosis-Associated Follicular Center Cell Lymphoma In The Retroperitoneum : The First Clinicopathologicla Study Of A Frequently Encountered Subtype Of Non-Hodgkin's Lymphoma, Michael Ethan Katz

Yale Medicine Thesis Digital Library

Follicular center cell lymphoma with sclerosis is a significant clinicopathologic entity which has received little attention to date. Its uniqueness has been obscured by quarrels over classification of the non-Hodgkin's lymphomas; and by the reluctance of some to accept it as a bona fide pathologic subtype in the retroperitoneum, its most common site of presentation. This thesis examines the clinical and pathological findings in a series of 22 cases of retroperitoneal follicular center cell lymphoma with sclerosis obtained from the hematopathology files of Yale-New Haven Hospital. Background material on the immunobiology, classification, and staging of non-Hodgkin's lymphomas is provided; and …


The Influences Of Cytotoxic Drugs And L1210 Suspension Culture Density On De Novo Purine Synthesis, Joyce Ann O'Shaughnessy Jan 1982

The Influences Of Cytotoxic Drugs And L1210 Suspension Culture Density On De Novo Purine Synthesis, Joyce Ann O'Shaughnessy

Yale Medicine Thesis Digital Library

No abstract provided.


Circulating Prolactin Levels In Potassium Loaded Rats, Christopher Newport Otis Jan 1982

Circulating Prolactin Levels In Potassium Loaded Rats, Christopher Newport Otis

Yale Medicine Thesis Digital Library

No abstract provided.


The Effects Of Tubercidin, 8-Azaadenosine, And Formycin On The Synthesis And Methylation Of Nuclear Rna In L1210 Mouse Leukemia Cells, Henry J. Stern Jan 1982

The Effects Of Tubercidin, 8-Azaadenosine, And Formycin On The Synthesis And Methylation Of Nuclear Rna In L1210 Mouse Leukemia Cells, Henry J. Stern

Yale Medicine Thesis Digital Library

No abstract provided.


Congenital Aortic Stenosis : And The Value Of Two-Dimensional Echocardiography In The Assessment Of Aortic Annulus Size, Mary Elizabeth Van Der Velde Jan 1982

Congenital Aortic Stenosis : And The Value Of Two-Dimensional Echocardiography In The Assessment Of Aortic Annulus Size, Mary Elizabeth Van Der Velde

Yale Medicine Thesis Digital Library

No abstract provided.


Clinical And Subclinical Iron-Deficiency Among Inner-City Adolescent Girls, Eric Donald Wells Jan 1982

Clinical And Subclinical Iron-Deficiency Among Inner-City Adolescent Girls, Eric Donald Wells

Yale Medicine Thesis Digital Library

No abstract provided.


Maternal Plasma 6-Keto Prostaglandin F1Α In Preeclampsia, Augusta Simpson Roth Jan 1982

Maternal Plasma 6-Keto Prostaglandin F1Α In Preeclampsia, Augusta Simpson Roth

Yale Medicine Thesis Digital Library

The possibility of decreased prostacyclin (PGI2) in preeclampsia-eclampsia is currently being studies by several laboratories. Because of prostacyclin's various actions (platelet aggregation inhabitation, vasodilation, stimulation of renin release, and possible inhibition of the hypertensive effects of angiotensin II), an increase in the peripheral activity of this chemical could explain much of the altered physiology of normal pregnancy. A relative decrease in peripheral activity could tie together the various pathophysiological findings of preeclampsia-eclampsia. Therefore, plasma 6-keto, PGF1α, the stable nonenzymatic metabolite of prostacyclin, was measured in women with preeclampsia, and in those women of various gestational ages having a normal pregnancy. …


Selective Contrast Sensitivity Loss In Strabismic Amblyopia, Sylvia R. Beck Jan 1982

Selective Contrast Sensitivity Loss In Strabismic Amblyopia, Sylvia R. Beck

Yale Medicine Thesis Digital Library

No abstract provided.


The Characterization And Functional Analysis Of Immuno-Regulatory Cells In Murine Bone Marrow, James Dean Michelson Jan 1982

The Characterization And Functional Analysis Of Immuno-Regulatory Cells In Murine Bone Marrow, James Dean Michelson

Yale Medicine Thesis Digital Library

No abstract provided.


Antibacterial Efficacy Of A Series Of Biologic Dressings In A Septic Burn Wound Model, Dan Baruch Odenheimer Jan 1982

Antibacterial Efficacy Of A Series Of Biologic Dressings In A Septic Burn Wound Model, Dan Baruch Odenheimer

Yale Medicine Thesis Digital Library

No abstract provided.


The Ideology Of Science And Medical Reform : A Case Study, The University Of Michigan, 1850-1920, Lewis Phillip Rubin Jan 1982

The Ideology Of Science And Medical Reform : A Case Study, The University Of Michigan, 1850-1920, Lewis Phillip Rubin

Yale Medicine Thesis Digital Library

No abstract provided.


Uptake, Metabolism, And Toxicity Of Cytosine Arabinoside In Human Leukemia Cells Following Sequenced 3-Deazauridine And Pyrazofurin Pretreatment, William M. Sikov Jan 1982

Uptake, Metabolism, And Toxicity Of Cytosine Arabinoside In Human Leukemia Cells Following Sequenced 3-Deazauridine And Pyrazofurin Pretreatment, William M. Sikov

Yale Medicine Thesis Digital Library

No abstract provided.


Clinicopharmacologic Study And Therapeutic Evaluation Of Oral Methotrexate Given 24 Hours Before 5-Fluorouracil In Cancer Patients : For Use In Patients With Advanced Breast Cancer, Ellen Tattelman Jan 1982

Clinicopharmacologic Study And Therapeutic Evaluation Of Oral Methotrexate Given 24 Hours Before 5-Fluorouracil In Cancer Patients : For Use In Patients With Advanced Breast Cancer, Ellen Tattelman

Yale Medicine Thesis Digital Library

No abstract provided.


A Methodologic Analysis Of Randomized Clinical Trials For Mild Hypertension, Patrick James Toth Jan 1982

A Methodologic Analysis Of Randomized Clinical Trials For Mild Hypertension, Patrick James Toth

Yale Medicine Thesis Digital Library

No abstract provided.


Retention Of Timolol In The Ocular Tissues Of The Rabbit, Albert Lon Ungricht Jan 1982

Retention Of Timolol In The Ocular Tissues Of The Rabbit, Albert Lon Ungricht

Yale Medicine Thesis Digital Library

No abstract provided.


The Doctrine Of Difficult Dentition : Evolution Of A Medical Nonentity, Jed Baron Gorlin Jan 1982

The Doctrine Of Difficult Dentition : Evolution Of A Medical Nonentity, Jed Baron Gorlin

Yale Medicine Thesis Digital Library

No abstract provided.


Maternal Plasma 6-Keto Prostaglandin F Alpha In Preeclampsia, Augusta Simpson Roth Jan 1982

Maternal Plasma 6-Keto Prostaglandin F Alpha In Preeclampsia, Augusta Simpson Roth

Yale Medicine Thesis Digital Library

No abstract provided.


The Extrarenal Effects Of Diuretics On Potassium Homeostasis In The Acutely Nephrectomized Rat, Lynn T. Tanoue Jan 1982

The Extrarenal Effects Of Diuretics On Potassium Homeostasis In The Acutely Nephrectomized Rat, Lynn T. Tanoue

Yale Medicine Thesis Digital Library

No abstract provided.


Energy-Dependent Translocation Of The Precursor Of Ornithine Transcarbamylase By Isolated Rat Liver Mitochondria, Daniel M. Kolansky Jan 1982

Energy-Dependent Translocation Of The Precursor Of Ornithine Transcarbamylase By Isolated Rat Liver Mitochondria, Daniel M. Kolansky

Yale Medicine Thesis Digital Library

No abstract provided.


The Effect Of Trace Metal Ions On The Growth Of Retinoblastoma Tumor Cells In Culture In The Presence And Absence Of Apotransferrin, Liba Goldblum Jan 1982

The Effect Of Trace Metal Ions On The Growth Of Retinoblastoma Tumor Cells In Culture In The Presence And Absence Of Apotransferrin, Liba Goldblum

Yale Medicine Thesis Digital Library

No abstract provided.


Correlation Of 8-Mop Plasma Levels And Skin Response To Uv-A Irradiation In Puva Patients, David P. Goldstein Jan 1982

Correlation Of 8-Mop Plasma Levels And Skin Response To Uv-A Irradiation In Puva Patients, David P. Goldstein

Yale Medicine Thesis Digital Library

No abstract provided.


Amino Acid And Glucose Metabolism Following Oral And Intravenous Amino Acid Administration In The Dog, Jeffrey Tepler Jan 1982

Amino Acid And Glucose Metabolism Following Oral And Intravenous Amino Acid Administration In The Dog, Jeffrey Tepler

Yale Medicine Thesis Digital Library

No abstract provided.


Computer Assisted Two-Compartment Pharmacokinetics For The Individualization Of Drug Dosing, Laurence A. Turka Jan 1982

Computer Assisted Two-Compartment Pharmacokinetics For The Individualization Of Drug Dosing, Laurence A. Turka

Yale Medicine Thesis Digital Library

No abstract provided.


Where Philosophy Meets Medicine : Acupuncture And Modern Physics, Kamau Kokayi Jan 1982

Where Philosophy Meets Medicine : Acupuncture And Modern Physics, Kamau Kokayi

Yale Medicine Thesis Digital Library

No abstract provided.


Melanocyte Migration In Guinea Pig : A Study Of The Relationship Of Melanocyte Population Density To Pigment Spread In Inoculation Grafts, Katalin Eve Roth Jan 1982

Melanocyte Migration In Guinea Pig : A Study Of The Relationship Of Melanocyte Population Density To Pigment Spread In Inoculation Grafts, Katalin Eve Roth

Yale Medicine Thesis Digital Library

No abstract provided.


The Significance Of Fever In Infants Less Than Three Months Old : A Retrospective Review Of One Year's Experience At Boston City Hospital's Pediatric Walk-In Clinic, Paula Chandler Schlesinger Jan 1982

The Significance Of Fever In Infants Less Than Three Months Old : A Retrospective Review Of One Year's Experience At Boston City Hospital's Pediatric Walk-In Clinic, Paula Chandler Schlesinger

Yale Medicine Thesis Digital Library

The hospital records of all outpatient infants 92 days of age or less with rectal temperature ≥ 100° F and/or chief complaint of fever who presented to Boston City Hospital's Pediatric Walk-In Clinic (PWIC) in the year 1981 were reviewed. There were 187 total study visits. The rectal temperature (T) in the PWIC was ≥ 100°F in 132 visits; half of these visits (66) were for T ≥ 101°F. The number of patients presenting with T ≥ 101°F increased with each month of age. The majority of study visits (56.1%) were for mild, self-limited illnesses; 14.4% of all visits were …


A Clinical Trial To Evaluate The Combination Of Clonidine And An Opiate Antagonist As A Method Of Methadone Detoxification, Paula Karen Braverman Jan 1982

A Clinical Trial To Evaluate The Combination Of Clonidine And An Opiate Antagonist As A Method Of Methadone Detoxification, Paula Karen Braverman

Yale Medicine Thesis Digital Library

No abstract provided.


Social And Cultural Factors Affecting Infantile Diarrhea In Lima, Peru, Gabriel J. Escobar Jan 1982

Social And Cultural Factors Affecting Infantile Diarrhea In Lima, Peru, Gabriel J. Escobar

Yale Medicine Thesis Digital Library

No abstract provided.