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Multiparametric Quantitative Acoustic Imaging Of Cervical Remodeling During Pregnancy, Yan Yan
Multiparametric Quantitative Acoustic Imaging Of Cervical Remodeling During Pregnancy, Yan Yan
Wayne State University Dissertations
The uterine cervix plays a central role in the maintenance of pregnancy and the process of parturition. Untimely cervical ripening in early gestation predisposes to preterm labor and delivery, the leading cause of infant mortality worldwide. The current approach to evaluate the status of the cervix relies on digital and sonographic examination, which indicates the morphological changes of the cervix (cervical length). Therefore, assessing cervix tissue composition changes may provide more sensitive evaluations about cervix status beyond cervical length. Photoacoustic (PA) imaging is a relatively new, non-invasive ultrasound (US) based technology that captures acoustic signals emitted by tissue components in …
Assessing Midbrain Abnormalities In Parkinson’S Disease Using Magnetic Resonance Imaging, Kiarash Ghassaban
Assessing Midbrain Abnormalities In Parkinson’S Disease Using Magnetic Resonance Imaging, Kiarash Ghassaban
Wayne State University Dissertations
Diagnosing early-stage Parkinson’s disease (PD) and its manifestations is still a clinical challenge. Previous imaging studies using iron, neuromelanin (NM) and the Nigrosome-1 (N1) measures in the substantia nigra (SN) by themselves have been unable to provide sufficiently high diagnostic performance for these methods to be adopted clinically. In this dissertation, we start by studying idiopathic PD patients at their intermediate stages of the disease to evaluate the role of global and regional iron in the major deep gray matter nuclei. Then, we only focus on the NM complex in the midbrain and how neuronal loss interact with iron overload …
The Advanced Applications For Optical Coherence Tomography In Skin Imaging, Qiuyun Xu
The Advanced Applications For Optical Coherence Tomography In Skin Imaging, Qiuyun Xu
Wayne State University Dissertations
Optical coherence tomography (OCT), based on the principle of interferometry, is a fast and non-invasive imaging modality, which has been approved by FDA for dermatologic applications. OCT has high spatial resolution up to micrometer scale compared to traditional ultrasound imaging. In addition, OCT can provide real-time cross-sectional images with 1 to 2 mm penetration depth, which makes it an ideal imaging technique to assess the skin micro-morphology and pathology without any tissue removal. Many studies have investigated the possibilities of using OCT to evaluate dermatologic conditions, such as skin cancer, dermatitis, psoriasis, and skin damages. Hence, OCT has tremendous potential …