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Development Of Rat Head Finite Element Model And Tissue Level Biomechanical Threshold For Traumatic Axonal Injury, Runzhou Zhou

Wayne State University Dissertations

Traumatic brain injury (TBI) is caused by local tissue deformation at the time of trauma, leading to neurological dysfunction. In the United States alone, 2.87 million people sustain a TBI each year, of which one-fifth results in death. Traumatic axonal injury (TAI) is a well-recognized consequence of every fatal head injury and more than 85% of vehicular crash-related blunt head injuries. The most common and important pathologic feature of TBIs are multifocal changes to axons in the white matter produced by rapid head acceleration/deceleration during a traumatic event with consequent local shear/tension on neural tissue and axons contributing to secondary …

The Eyes Never Lie: Detecting Simulated Traumatic Brain Injury With Eye-Tracking, Robert John Kanser

Wayne State University Dissertations

Performance validity test (PVT) inaccuracies can be explained by both test and extra-test (e.g., research design components) factors. Eye-tracking is a promising technology to enhance assessment of performance validity. Prior research has established that ocular behaviors are reliable biomarkers of (un)conscious cognitive processes. Experimental research on deception has shown that ocular behaviors reliably distinguish feigned concealment of information from honest responding. The primary objective of this study was to examine the incremental utility of incorporating eye-tracking into a clinical PVT to distinguish adults with verified TBI from adults coached to feign cognitive impairment. A secondary objective was to determine the …

A Study Of The Relationship Between Resilience And Job Satisfaction In Direct Care Workers Who Work With Traumatic Brain Injured Clients, Michele Terese White

Wayne State University Dissertations

The direct care worker occupation is a very fast and growing workforce. In fact, by the year 2016, it is estimated that it might be the largest workforce in the country. With the rapid growth come difficulties. One of those difficulties is a high turn over rate. Research shows that people that are resilient stay longer at a job versus those who are not resilient. Is there a relationship between resilience and job satisfaction? This research sought to determine if a relationship existed. The research delved into a particular field, traumatic brain injury. This research study attempted to determine if …

Comparison Of Progression Of Diffuse Axonal Injury With Histology And Diffusion Tensor Imaging, Nisrine Zakaria

Wayne State University Dissertations

Diffuse axonal injury, also known as traumatic axonal injury (TAI), is a major contributor to the pathology of traumatic brain injury. However, TAI is undetectable to conventional clinical magnetic resonance (MR) imaging techniques. Histologically, TAI is characterized by swollen axons that eventually disconnect and form axonal retraction balls (RB) in various white matter tracts. MR-diffusion tensor imaging (MR-DTI) has been reported to be sensitive to TAI in human TBI patients by measuring water molecular diffusion motion in white matter fiber tracts. To date, only one correlative animal study has been carried out to investigate the DTI relationship to TAI, and …

Long-Term Psychological Outcomes And Awareness Of Deficit In Persons With Traumatic Brain Injury And Their Significant Others: The Role Of Physiological And Neuroendocrine Reactivity To Stress, Sarah J. Meachen

Wayne State University Dissertations

This study investigated the relationships between physiological/neuroendocrine reactivity to stress and long-term psychological outcomes among persons with TBI and their significant others. In addition, this study examined the potential moderating role of patient AOD in characterizing these relationships. The findings indicate that physiological stress reactivity predicts poor psychosocial functioning in survivors of TBI and their significant others. Chronic stress (reflected in high baseline values) and stress reactivity were generally adversely associated with psychological distress and life satisfaction. Among significant others of TBI survivors, this pattern was also observed for sense of caregiving mastery and burden. However, there were also some …

The Influence Of Religion And Spirituality On Rehabilitation Outcomes Among Traumatic Brain Injury Survivors, Brigid Waldron-Perrine

Wayne State University Dissertations

The long-term consequences of traumatic brain injury affect millions of Americans, many of whom report using religion and spirituality to cope. Little research, however, has investigated how various elements of the religious and spiritual belief systems affect rehabilitation outcomes. The present study sought to assess the use of specifically defined elements of religion and spirituality as coping resources in a sample of traumatically brain injured adults. Furthermore, various mechanisms by which religion and spirituality may affect outcome were explored.

The sample included 88 adults with brain injury from 1 to 20 years post injury and their knowledgeable significant others (SOs). …