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Wayne State University Dissertations

Theses/Dissertations

2011

Cortisol

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Circadian Rhythm Of Cortisol And Estradiol In Healthy Women, Karyn G. Butler Jan 2011

Circadian Rhythm Of Cortisol And Estradiol In Healthy Women, Karyn G. Butler

Wayne State University Dissertations

ABSTRACT

CIRCADIAN RHYTHM OF CORTISOL AND ESTRADIOL IN HEALTHY WOMEN

by

KARYN G. BUTLER

AUGUST 2011

Advisor: Dr. Jean E. Davis

Major: Nursing

Degree: Doctor of Philosophy

Daily variation in human processes and behaviors has been identified for centuries. Study of these circadian rhythms demonstrates their role in human health. Sickness behaviors include alterations in affect, sleep quality and energy. The study of the relationship between circadian rhythms has been limited to isolated rhythms. The role of temporal relationships among rhythms has received little attention. Sickness behaviors are prevalent in many disorders including depression, cancer, and autoimmune disorders. Two hormones …


Long-Term Psychological Outcomes And Awareness Of Deficit In Persons With Traumatic Brain Injury And Their Significant Others: The Role Of Physiological And Neuroendocrine Reactivity To Stress, Sarah J. Meachen Jan 2011

Long-Term Psychological Outcomes And Awareness Of Deficit In Persons With Traumatic Brain Injury And Their Significant Others: The Role Of Physiological And Neuroendocrine Reactivity To Stress, Sarah J. Meachen

Wayne State University Dissertations

This study investigated the relationships between physiological/neuroendocrine reactivity to stress and long-term psychological outcomes among persons with TBI and their significant others. In addition, this study examined the potential moderating role of patient AOD in characterizing these relationships. The findings indicate that physiological stress reactivity predicts poor psychosocial functioning in survivors of TBI and their significant others. Chronic stress (reflected in high baseline values) and stress reactivity were generally adversely associated with psychological distress and life satisfaction. Among significant others of TBI survivors, this pattern was also observed for sense of caregiving mastery and burden. However, there were also some …