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Development Of Mass Spectrometry-Based Methods For The Analysis Of Lipid Isomers, Rachel Kozlowski
Development Of Mass Spectrometry-Based Methods For The Analysis Of Lipid Isomers, Rachel Kozlowski
University of Wollongong Thesis Collection 1954-2016
Glycerophospholipids, or phospholipids, are important biochemical components of many biological organisms. They are involved in many biochemical processes including signal transduction, serving as enzyme substrates for lipoprotein metabolism and serving as ligands for receptors and precursors of essential biomolecules; they are also intracellular traffickers of cholesterol as well as modulators of the immune system. Likely to fulfill these diverse functional roles, not only do phospholipids contain a variety of head groups attached to a glycerol backbone but even more diversity exists within the fatty acyl chain(s) that are attached to the same glycerol backbone. These differences can be very subtle …
Investigations Of Peroxidation Of Membrane Phospholipids, Colin H. Cortie
Investigations Of Peroxidation Of Membrane Phospholipids, Colin H. Cortie
University of Wollongong Thesis Collection 1954-2016
The deterioration of lipids by oxygen, termed peroxidation, is a constitutive process in living systems. Enzymatic peroxidation is required for some forms of cell signalling, but the non-enzymatic peroxidation of polyunsaturated fatty acids (PUFA) produces numerous toxic and mutagenic products associated with pathology and aging. Phospholipids containing PUFA are common in mammalian membranes, but an inverse relationship has been found between membrane susceptibility to peroxidation and maximal lifespan (MLS). Past studies of peroxidation have focused on the PUFA content of phospholipids, but other elements of phospholipid composition including class and saturated fatty acid (SFA) or monounsaturated fatty acid (MUFA) content …
Investigating Changes In Human Brain Phospholipids During Normal Ageing, Sarah E. Hancock
Investigating Changes In Human Brain Phospholipids During Normal Ageing, Sarah E. Hancock
University of Wollongong Thesis Collection 1954-2016
The world’s population is rapidly ageing, and with that has come a corresponding increase in the number of people suffering age-related diseases. Dementia is a group of age-related neurocognitive disorders, with the most common of these being Alzheimer’s disease (AD). The number one risk factor for developing AD is advanced age, with the incidence rising from 1 in 10,000 at age 60 to 1 in 3 by age 85. AD is characterised by the deposition of extracellular amyloid-β aggregates (Aβ) and intracellular neurofibrillary tangles (NFTs) formed by hyperphosphorylated tau. Both Aβ and NFTs spread throughout the brain by separate but …