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Development Of Mass Spectrometry-Based Methods For The Analysis Of Lipid Isomers, Rachel Kozlowski
Development Of Mass Spectrometry-Based Methods For The Analysis Of Lipid Isomers, Rachel Kozlowski
University of Wollongong Thesis Collection 1954-2016
Glycerophospholipids, or phospholipids, are important biochemical components of many biological organisms. They are involved in many biochemical processes including signal transduction, serving as enzyme substrates for lipoprotein metabolism and serving as ligands for receptors and precursors of essential biomolecules; they are also intracellular traffickers of cholesterol as well as modulators of the immune system. Likely to fulfill these diverse functional roles, not only do phospholipids contain a variety of head groups attached to a glycerol backbone but even more diversity exists within the fatty acyl chain(s) that are attached to the same glycerol backbone. These differences can be very subtle …
Investigating Changes In Human Brain Phospholipids During Normal Ageing, Sarah E. Hancock
Investigating Changes In Human Brain Phospholipids During Normal Ageing, Sarah E. Hancock
University of Wollongong Thesis Collection 1954-2016
The world’s population is rapidly ageing, and with that has come a corresponding increase in the number of people suffering age-related diseases. Dementia is a group of age-related neurocognitive disorders, with the most common of these being Alzheimer’s disease (AD). The number one risk factor for developing AD is advanced age, with the incidence rising from 1 in 10,000 at age 60 to 1 in 3 by age 85. AD is characterised by the deposition of extracellular amyloid-β aggregates (Aβ) and intracellular neurofibrillary tangles (NFTs) formed by hyperphosphorylated tau. Both Aβ and NFTs spread throughout the brain by separate but …
Dna-Binding Interactions Of Nickel Schiff Base Complexes, Nawal Masoud O Assadawi
Dna-Binding Interactions Of Nickel Schiff Base Complexes, Nawal Masoud O Assadawi
University of Wollongong Thesis Collection 1954-2016
A series of eleven different nickel Schiff base complexes was synthesized by a two-step procedure. Initially ethylenediamine, phenylenediamine or meso- 1,2-diphenylethylenediamine was reacted with either 2,3- or 2,5- dihydroxybenzaldehyde in the presence of Ni(II) to afford six novel dihydroxylated nickel Schiff base complexes. Five of these complexes were then successfully reacted with 1-(2-chloroethyl) piperidine hydrochloride to form a series of derivatives featuring two appended ethyl piperidine moieties. All new complexes were characterised using 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, elemental microanalysis and in some instances electrospray ionisation mass spectrometry (ESI-MS). The solidstate structures of three nickel complexes (5), …